Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years

Rydberg, Mattias; Zimmerman, Malin; Löfgren, Jin Persson; Gottsäter, Anders; Nilsson, Peter M.; Melander, Olle; Dahlin, Lars B.

doi:10.1038/s41598-021-94025-7

Cited by 17 publications

(18 citation statements)

References 38 publications

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“…At present, gender may also be one of the key factors affecting the occurrence of DC. For example, Rydberg et al [ 21 ] found a strong correlation between apolipoprotein levels and the occurrence of DC in patients of different genders. Another study found that androgens can act on the palmar fascia and the expression level of androgen receptors in patients with DC was significantly higher than that in normal palms, suggesting that androgen response status is associated with a higher incidence of DC in male patients [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Dupuytren’s Contracture: A Case-Control Study

Zheng

Chen

Liu

et al. 2022

Computational Intelligence and Neuroscience

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Objective. To study the risk factors of Dupuytren’s contracture (DC) and to provide a reference for the clinical prevention and treatment of DC. Methods. The clinical data of 21 DC patients treated with surgery in Qilu Hospital of Shandong University (Qingdao) from March 2014 to January 2022 were collected. During the same period, 31 subjects who were admitted to the hospital for treatment of finger numbness, difficulty in movement, and other reasons were selected as the control group, and the clinical data of the control group were collected. A case-control study was used to analyze the risk factors for DC. The receiver operating curve (ROC) was used to analyze the efficacy of blood biochemical indexes and coagulation-related indexes in predicting the occurrence of DC. Results. Multivariate logistic regression analysis showed that male and diabetes were independent risk factors for the occurrence of DC (HR = 19.69, 95%CI: 3.12–124.19, P = 0.002; HR = 7.61, 95%CI: 1.25–46.47, P = 0.03). The results of the ROC analysis showed that the area under the curve (AUC) for the DC predicted by cystatin C was 0.7565 (95%CI: 0.6203–0.8928, P = 0.0018), and the AUC for the DC predicted by blood chloride level was 0.8121 (95%CI: 0.6880–0.9362, P = 0.0002), the AUC for the DC predicted by fibrinogen was 0.7796 (95%CI: 0.6439–0.9152, P = 0.0007), the AUC for the DC predicted by D-dimer level was 0.8740 (95%CI: 0.7812–0.9669, P < 0.0001), and the AUC for the DC predicted by thrombin time was 0.7803 (95%CI: 0.6411–0.9196, P = 0.0007). The AUC for the DC predicted by the combined detection of cystatin C, blood chloride, fibrinogen, D-dimer, and thrombin time was 0.9441 (95%CI: 0.8926–0.9957, P < 0.001). Conclusion. Male and diabetes are independent risk factors for the occurrence of DC. Combined detection of cystatin C, blood chloride, fibrinogen, D-dimer, and thrombin time has a certain value in predicting the occurrence of DC.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Dupuytren’s Contracture: A Case-Control Study

Zheng

Chen

Liu

et al. 2022

Computational Intelligence and Neuroscience

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“…Nevertheless, also several non-structural ECM proteins such as mimecan, periostin, decorin and TGFBI were upregulated in DC associated sweat glands. Mimecan, periostin, decorin and TGFBI are proteins that have been shown to interact with fibrillar collagens, growth factors and growth factor receptors and thus influence ECM assembly, cellular growth, and migration [ 1 , 2 , 3 ]. TGFBI has been shown to be induced by TGF-β [ 34 ] and can affect heart and renal fibrosis [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence rates of this disease depend on the population group analyzed and are significantly higher in middle-aged or older men of Northern European descent [ 2 ]. In addition, metabolic factors such as diabetes mellitus and excessive alcohol consumption constitute the main risk factors for development of DC [ 3 ]. Other risk factors include smoking, increasing age, male gender, epilepsy, and genetic predisposition [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Proteomic Analysis of Dupuytren’s Contracture-Derived Sweat Glands Revealed the Synthesis of Connective Tissue Growth Factor and Initiation of Epithelial-Mesenchymal Transition as Major Pathogenetic Events

Cárdenas-León

Mäemets-Allas

Klaas

et al. 2023

IJMS

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Dupuytren’s contracture (DC) is a chronic and progressive fibroproliferative disorder restricted to the palmar fascia of the hands. Previously, we discovered the presence of high levels of connective tissue growth factor in sweat glands in the vicinity of DC nodules and hypothesized that sweat glands have an important role in the formation of DC lesions. Here, we shed light on the role of sweat glands in the DC pathogenesis by proteomic analysis and immunofluorescence microscopy. We demonstrated that a fraction of sweat gland epithelium underwent epithelial-mesenchymal transition illustrated by negative regulation of E-cadherin. We hypothesized that the increase in connective tissue growth factor expression in DC sweat glands has both autocrine and paracrine effects in sustaining the DC formation and inducing pathological changes in DC-associated sweat glands.

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“…The disease is one of the most common hereditary disorders of the connective tissue, and has strong associations with genetic profiles and family history [3]. In previous studies, male gender, diabetes mellitus, excess alcohol consumption and smoking were identified as major risk factors for its development [4,5]. The current worldwide prevalence of DC is estimated to be around 8.2% [6], a rate which varies greatly with geographic location.…”

Section: Introductionmentioning

confidence: 99%

Short-term efficacy and adverse effects of collagenase clostridium histolyticum injections, percutaneous needle fasciotomy and limited fasciectomy in the treatment of Dupuytren’s contracture: a network meta-analysis of randomized controlled trials

Obed

Salim

Schlottmann

et al. 2022

BMC Musculoskelet Disord

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Aims Dupuytren’s contracture (DC) is a chronic debilitating fibroproliferative disorder. Common treatment options include collagenase clostridium histolyticum injections (CI), percutaneous needle fasciotomy (NF) and limited fasciectomy (LF). Superiority of one specific treatment remains controversial. This study aims to assess the short-term efficacy and safety of CI, NF, and LF for the treatment of DC. Methods We included randomized controlled trials of CI compared with placebo, NF and LF for patients with DC. PubMed, Embase and the Cochrane Library were searched from inception to August 2021. Contracture reduction rates in treated joints (within 0–5° of full extension within 30 days), relative reduction in total passive extension deficit (TPED), occurrence of one or more adverse events and number of treatment-related adverse events per patient were the outcomes of interest. The Cochrane risk-of-bias tool was employed for quality assessment of the studies. A network meta-analysis was performed using MetaXL. Results Nine studies met our inclusion criteria (n = 903). Overall, risk bias was mixed and mostly low. Short term TPED reduction achieved with LF was superior compared to CI and NF. Although CI achieved greater TPED reduction compared to NF, it was associated with the highest risk of overall adverse effects. The analyzed data was limited to a maximum three-year follow-up period and therefore insufficient for long-term outcome evaluation. Conclusions In DC, LF may be able to provide patients with severe disease, superior flexion contracture release postoperatively. CI is a valid treatment alternative to NF, however the higher risk of overall adverse effects must be considered. The quality-of-evidence is limited due to short-term follow-up periods and a lack of standardized definitions of complications and adverse events.

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Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years

Cited by 17 publications

References 38 publications

Risk Factors for Dupuytren’s Contracture: A Case-Control Study

Risk Factors for Dupuytren’s Contracture: A Case-Control Study

Proteomic Analysis of Dupuytren’s Contracture-Derived Sweat Glands Revealed the Synthesis of Connective Tissue Growth Factor and Initiation of Epithelial-Mesenchymal Transition as Major Pathogenetic Events

Short-term efficacy and adverse effects of collagenase clostridium histolyticum injections, percutaneous needle fasciotomy and limited fasciectomy in the treatment of Dupuytren’s contracture: a network meta-analysis of randomized controlled trials

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