Metabolic imaging of tissues by infrared fiber-optic spectroscopy: an efficient tool for medical diagnosis

Hocdé, Sandrine; Loréal, Olivier; Sire, Olivier; Boussard‐Plédel, Catherine; Bureau, Bruno; Turlin, Bruno; Keirsse, Julie; Leroyer, Patricia; Lucas, Jacques

doi:10.1117/1.1646415

Cited by 70 publications

(34 citation statements)

References 10 publications

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“…[18] This study was performed as part of an intensive cooperation program conducted together with the Rennes university hospital. Figure 13 shows an IR fibre a few millimetres in length coated with enrolled slices of liver tissues that have been cryogenically cut to a thickness of 10 mm.…”

Section: Infrared Fibres For Evanescent Wave Spectroscopymentioning

confidence: 99%

Glasses for Seeing Beyond Visible

Zhang

Bureau

Lucas

et al. 2007

Chemistry A European J

137

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Conventional glasses based on oxides have a transparency limited by phonon absorption in the near IR region and have a limited interest for analyzing information located far beyond the visible. The IR spectral domain is nevertheless of prime interest, since it covers fundamental wavelength ranges used for thermal imaging as well as molecular vibrational signatures. Besides spectacular advances in the field of IR detectors, the main significant progresses are related to the development of IR glass optics, such as lenses or IR optical fibres. The field of IR glasses is almost totally dominated by glasses formed from heavy atoms such as the chalcogens S, Se and Te. Their transparency extends up to 12, 16 and 28 microm for sulfide-, selenide- and the new generation of telluride-based glasses, respectively. They cover the atmospheric transparency domains, 3-5 and 8-13 microm, respectively, at which the IR radiation can propagate allowing thermal imaging and night-vision operations through thick layers of atmosphere. The development of new glass compositions will be discussed on the basis of structural consideration with the objective of moulding low-cost lenses for IR cameras used, for instance, in car-driving assistance. Additionally, multimode, single-index, optical fibres operating in the 3 to 12 microm window developed for in situ remote evanescent-wave IR spectroscopy will also be mentioned. The detection of molecular IR signatures is applied to environmental monitoring for investigating the pollution of underground water with toxic molecules. The extension of this technique to the investigation of biomolecules in three different studies devoted to liver tissues analysis, bio-film formation, and cell metabolism will also be discussed. Finally we will mention the developments in the field of single-mode fibres operating around 10 mum for the Darwin space mission, which is aiming at discovering, signs of biological life in telluric earth-like exoplanets throughout the universe.

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Section: Infrared Fibres For Evanescent Wave Spectroscopymentioning

confidence: 99%

Glasses for Seeing Beyond Visible

Zhang

Bureau

Lucas

et al. 2007

Chemistry A European J

137

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show abstract

“…La méthode permet ainsi de recueillir une empreinte métabolique des échantillons. Il est ensuite possible d'utiliser des modèles statistiques pour détecter des variations de cette empreinte, et de mettre à profit ces variations comme marqueur d'un état pathologique ou sain [18][19][20][21][22][23].…”

Section: Introductionunclassified

Une nouvelle méthode pour le diagnostic rapide d’arthrite septique utilisant la spectroscopie infrarouge

Albert¹,

Monbet²,

Jolivet‐Gougeon³

et al. 2016

Revue du Rhumatisme

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“…Chalcogenide glasses are of paramount interest for night visibility devices, for medical applications [1][2][3] or for chemical analyses because of their remarkable transparency in the 3-12 m range (second atmospheric window). Within chalcogenide glasses, those from the tellurium-arsenic-selenium system (TAS) are very resistant to devitrification and can be drawn into optical fibers which offer exceptional transparency in the mid infrared range.…”

Section: Introductionmentioning

confidence: 99%