Metabolic Immunity as a Factor in Assessing the Reactivity of the Body

Земсков, А. М.; Zemskov, V. M.; Lutsky, Marta; Suchkov, Sergey; Земскова, В. А.; Золоедов, В. И.

doi:10.1134/s2079086418040096

Cited by 3 publications

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“…В целом преимущество активированных иммунных параметров было превалирующим. Лишь у носителей HBs Aг преимущество было за иммуносупрессией, составляя 69% против 39% случаев [20].…”

Section: альтернативность иммунных реакцийunclassified

“…Иммунные функции организма постоянно осуществляются на фоне метаболических процессов и их сдвигов, вызываемых действием различных биологических агентов, патологических процессов и заболеваний, лекарственных препаратов, особенностей питания и др. [20,25].…”

Section: альтернативность иммунных реакцийunclassified

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Immune reactions as induction factors and correction of the pathology

Zemskov¹,

Земсков

Neymann³

et al. 2022

Medicinskij sovet

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On clinical models of infectious, somatic, malignant, and other diseases, the ability of immune responses to induce pathological processes due to competition, “pathogenicity”, hypersensitivity, and insufficiency has been shown. We are talking about the competitiveness of antibacterial and antiviral immunity, when the deployment of cellular and humoral immune responses weaken both defense mechanisms, competition of allergy and immune deficiency, which aggravates and modifies it, and antiviral immunity often induces a number of pathological conditions of the body. This is due to the inability of antiviral antibodies to completely inactivate the antireceptor structures of virions, interact with them without changing their function, and even stimulate a viral infection, induce autoimmune reactions. The protective system of interferons, which often cause side reactions, is also faulty. In the body, immunopathological reactions develop, manifested by immediate and delayed hypersensitivity, which have alternative properties – protective and damaging and autoimmune reactions, mainly with a negative effect. The mechanisms of the processes are discussed in detail in the review. The “inferiority” of immune reactions, respectively, cellular, humoral, phagocytic links, incomplete consistency of anticancer immunity, virus-induced immunodeficiencies are comprehensively covered. Such “alternativeness” of the considered immune reactions, at the same time, turns out to be a necessary condition for eliminating the emerging disorders of the organism’s reactivity. These include specificity and non-specificity, stimulation and suppression, variability and integration of immune responses. At the same time, immunoregulatory reactions are individual and interrelated, develop regionally and systemically and provide degradation of exogenous and endogenous objects and immune activation. All these aspects are discussed in detail in the review.

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Section: альтернативность иммунных реакцийunclassified

Immune reactions as induction factors and correction of the pathology

Zemskov¹,

Земсков

Neymann³

et al. 2022

Medicinskij sovet

Self Cite

View full text Add to dashboard Cite

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Unorthodox Phenomena of Clinical Immunology

2020

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A correlation between anxiety-depressive symptoms and immune-metabolic parameters in patients with mixed anxiety and depressive disorder

Bakuleva,

Shiryaev,

Zemskova

et al. 2024

Bulletin of Neurology, Psychiatry and Neurosurgery

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According to literature data, anxiety and depressive disorders are the most common mental diseases worldwide. Currently, a hypothesis of possible immune metabolic regulation of the central nervous system was put forward. The authors evaluated the indicators of humoral, cellular, and metabolic immunity in patients suffering from mixed anxiety and depressive disorder, who were under the supervision of a psychiatrist at the day hospital of the Voronezh Regional Clinical Psychoneurological Dispensary. Indicators of anxiety and depression were assessed by means of psychometric method, clinical interview, and clinical psychopathological examination, and the indicators of immune and metabolic status were examined. It was found that symptoms of anxiety and depression were accompanied by changes in immune and metabolic status. It is supposed that variations in clinical, immunological, and metabolic parameters are coordinated elements of a single pathogenetic mechanism for the formation of anxiet y-depressive spectrum disorders.

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Metabolic Immunity as a Factor in Assessing the Reactivity of the Body

Cited by 3 publications

References 0 publications

Immune reactions as induction factors and correction of the pathology

Immune reactions as induction factors and correction of the pathology

Unorthodox Phenomena of Clinical Immunology

A correlation between anxiety-depressive symptoms and immune-metabolic parameters in patients with mixed anxiety and depressive disorder

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