Metabolic impact of adipose tissue macrophages in the early postnatal life

Röszer, Tamás

doi:10.1002/jlb.3mr0722-201r

Cited by 8 publications

(3 citation statements)

References 139 publications

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“…Human milk-specific alkylglycerol-type ether lipids (AKGs) maintain thermogenic adipose tissue in young mice ( Figure 2 c). The underlying mechanism requires ATMs, which colonize the developing adipose tissue at birth [ 21 , 95 , 96 ] and metabolize nutritional AKGs to platelet-activating factor (PAF). PAF functions as a paracrine signal to preadipocytes and adipocytes and activates an autocrine IL-6/STAT3 signaling ( Figure 2 c).…”

Section: Local Il-6 Signaling Stimulates Thermogenic Fat Development ...mentioning

confidence: 99%

Interleukin-6: An Under-Appreciated Inducer of Thermogenic Adipocyte Differentiation

Radványi,

Röszer

2024

IJMS

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Adipose tissue inflammation is a key factor leading to obesity-associated immune disorders, such as insulin resistance, beta cell loss in the pancreatic islets, meta-inflammation, and autoimmunity. Inhibiting adipose tissue inflammation is considered a straightforward approach to abrogate these diseases. However, recent findings show that certain pro-inflammatory cytokines are essential for the proper differentiation and functioning of adipocytes. Lipolysis is stimulated, and the thermogenic competence of adipocytes is unlocked by interleukin-6 (IL-6), a cytokine that was initially recognized as a key trigger of adipose tissue inflammation. Coherently, signal transducer and activator of transcription 3 (STAT3), which is a signal transducer for IL-6, is necessary for thermogenic adipocyte development. Given the impact of thermogenic adipocytes in increasing energy expenditure and reducing body adiposity, functions of IL-6 in the adipose tissue have gained attention recently. In this review, we show that IL-6 signaling may protect from excess fat accumulation by stimulating thermogenesis in adipocytes.

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Section: Local Il-6 Signaling Stimulates Thermogenic Fat Development ...mentioning

confidence: 99%

Interleukin-6: An Under-Appreciated Inducer of Thermogenic Adipocyte Differentiation

Radványi,

Röszer

2024

IJMS

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“…Adipocytes produce their own cytokines, also known as adipokines, causing chronic inflammation in the adipose tissue (AT) [279,280]. AT macrophages (ATM) intensify this metabolic dysfunction of adipocytes, increasing inflammation within the cells [281]. Leptin and adiponectin are major adipokines regulating lipid metabolism and glucose levels within the AT, and dysregulation of adipokines is associated with obesity [27].…”

Section: Adipokine Dysregulation and Metabolic Inflammationmentioning

confidence: 99%

Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated

Kim,

Lee,

et al. 2023

Nutrients

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Endoplasmic reticulum (ER) stress plays a pivotal role in adipogenesis, which encompasses the differentiation of adipocytes and lipid accumulation. Sustained ER stress has the potential to disrupt the signaling of the unfolded protein response (UPR), thereby influencing adipogenesis. This comprehensive review illuminates the molecular mechanisms that underpin the interplay between ER stress and adipogenesis. We delve into the dysregulation of UPR pathways, namely, IRE1-XBP1, PERK and ATF6 in relation to adipocyte differentiation, lipid metabolism, and tissue inflammation. Moreover, we scrutinize how ER stress impacts key adipogenic transcription factors such as proliferator-activated receptor γ (PPARγ) and CCAAT-enhancer-binding proteins (C/EBPs) along with their interaction with other signaling pathways. The cellular ramifications include alterations in lipid metabolism, dysregulation of adipokines, and aged adipose tissue inflammation. We also discuss the potential roles the molecular chaperones cyclophilin A and cyclophilin B play in adipogenesis. By shedding light on the intricate relationship between ER stress and adipogenesis, this review paves the way for devising innovative therapeutic interventions.

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“…Comparing both strategies, disease tolerance and disease resistance, one major benefit of disease tolerance is that it is less energetically demanding [ 6 ]. For neonates, this is highly relevant considering the energetic constrains of early life due to limited energy reserves and the large demand of the newborn to sustain its core body temperature [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

New Insights in Immunometabolism in Neonatal Monocytes and Macrophages in Health and Disease

de Jong,

Tenbrock,

Ohl

2023

IJMS

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It is well established that the neonatal immune system is different from the adult immune system. A major task of the neonatal immune system is to bridge the achievement of tolerance towards harmless antigens and commensal bacteria while providing protection against pathogens. This is highly important because neonates are immunologically challenged directly after birth by a rigorous change from a semi-allogeneic sterile environment into a world rich with microbes. A so called disease tolerogenic state is typical for neonates and is anticipated to prevent immunopathological damage potentially at the cost of uncontrolled pathogen proliferation. As a consequence, neonates are more susceptible than adults to life-threatening infections. At the basis of a well-functioning immune response, both for adults and neonates, innate immune cells such as monocytes and monocyte-derived macrophages play an essential role. A well-responsive monocyte will alter its cellular metabolism to subsequently induce certain immune effector function, a process which is called immunometabolism. Immunometabolism has received extensive attention in the last decade; however, it has not been broadly studied in neonates. This review focuses on carbohydrate metabolism in monocytes and macrophages in neonates. We will exhibit pathways involving glycolysis, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation and their role in shaping neonates’ immune systems to a favorable tolerogenic state. More insight into these pathways will elucidate potential treatments targets in life-threatening conditions including neonatal sepsis or expose potential targets which can be used to induce tolerance in conditions where tolerance is harmfully impaired such as in autoimmune diseases.

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Metabolic impact of adipose tissue macrophages in the early postnatal life

Cited by 8 publications

References 139 publications

Interleukin-6: An Under-Appreciated Inducer of Thermogenic Adipocyte Differentiation

Interleukin-6: An Under-Appreciated Inducer of Thermogenic Adipocyte Differentiation

Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated

New Insights in Immunometabolism in Neonatal Monocytes and Macrophages in Health and Disease

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