“…Protein transduction domain-fused Dishevelled binding motif (PTD-DBM) peptide, which interferes with the CXXC5-Dvl protein-protein interaction (PPI), promotes cutaneous wound healing and neogenic hair growth through the restoration of Wnt/β-catenin signaling 19,24 . In addition, small molecular mimetics of PTD-DBM peptide that interferes the function of CXXC5, such as KY19382 and KY19334, induce wound healing, hair growth, and longitudinal bone growth, and improve metabolic abnormalities, including diabetes, by activating Wnt/β-catenin signaling 19,20,[22][23][24] . The effectiveness of small molecules that interfere with the function of cytosolic CXXC5 further confirmed the CXXC5-Dvl PPI as a target for treating diseases with suppressed Wnt/β-catenin signaling, such as baldness, bone growth senescence, and metabolic diseases such as obese type 2 diabetes and nonalcoholic steatohepatitis [20][21][22][23] .…”