2019
DOI: 10.1038/s41598-019-51058-3
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Metabolic output defines Escherichia coli as a health-promoting microbe against intestinal Pseudomonas aeruginosa

Abstract: Gut microbiota acts as a barrier against intestinal pathogens, but species-specific protection of the host from infection remains relatively unexplored. Although lactobacilli and bifidobacteria produce beneficial lactic and short-chain fatty acids in the mammalian gut, the significance of intestinal Escherichia coli producing these acids is debatable. Taking a Koch’s postulates approach in reverse, we define Escherichia coli as health-promoting for naturally colonizing the gut of healthy mice and protecting th… Show more

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Cited by 42 publications
(38 citation statements)
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“…aeruginosa, though not a regular member of the physiological gut-microbiota, is frequently involved in intestinal infections and inflammatory conditions like colitis, gastroenteritis, and diarrhea. [39][40][41] P. aeruginosa secretes protein FapC, which self-assembles into functional amyloid fibrils to constitute the biofilm scaffold. [40,42] The Fap operon is also shared by other opportunistic gastric pathogens like Aeromonas caviae and Laribacter hongkongensis.…”
Section: Scheme Of Studymentioning
confidence: 99%
“…aeruginosa, though not a regular member of the physiological gut-microbiota, is frequently involved in intestinal infections and inflammatory conditions like colitis, gastroenteritis, and diarrhea. [39][40][41] P. aeruginosa secretes protein FapC, which self-assembles into functional amyloid fibrils to constitute the biofilm scaffold. [40,42] The Fap operon is also shared by other opportunistic gastric pathogens like Aeromonas caviae and Laribacter hongkongensis.…”
Section: Scheme Of Studymentioning
confidence: 99%
“…in the genera Buchnera and Sodalis). Many members of this family produce toxins called microcins [38], which may explain their ability to prevent mammalian gut colonization by pathogens [39,40]. In addition, they could directly benefit hosts by degrading complex dietary polysaccharides, or synthesizing limiting nutrients such as vitamins for the host.…”
Section: Plos Onementioning
confidence: 99%
“…Being a facultative anaerobe, E. coli helps creating an anaerobic environment by consuming the remaining oxygen in the gut [ 27 ]. It plays beneficial roles in human health by producing vitamin K [ 28 ] and conferring resistance to invading pathogens [ 29 , 30 ]. Despite its lower abundance in the human gut compared to several other major gut bacteria such as Bi fidobacterium, Bacteroides, Clostridium , etc., it is one of the most common gut colonizers [ 16 , 27 ].…”
Section: Introductionmentioning
confidence: 99%