Metabolic pancreatitis: Etiopathogenesis and management

Kota, Sunil Kumar; Krishna, Surabhi Venkata Satya; Lakhtakia, Sandeep; Modi, Kirtikumar D

doi:10.4103/2230-8210.117208

Cited by 46 publications

(30 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Because of its potential to trigger systemic inflammatory response, it can cause multiple organ failure (1,2). The common causes of acute pancreatitis are alcohol abuse or gallstone disease (60%-75% of the cases) followed by hypertriglyceridemia, hyperparathyroidism, pancreatic malignancy, endoscopic retrograde cholangiopancreatography, trauma, infectious agents (increasingly associated with HIV infection), drugs (such as tetracycline, azathioprine, ethinyl estradiol, mercaptopurine, and sulfamethoxazole), autoimmunity, abdominal trauma, ischemia, diabetes mellitus, porphyria, and heredity (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Effects of everolimus on a rat model of cerulein-induced experimental acute pancreatitis

Özkardeş¹,

Bozkurt²,

Dumlu³

et al. 2015

UCD

View full text Add to dashboard Cite

Objective: To analyze the biochemical and histopathological effects of everolimus in an experimental rat model of cerulein-induced acute pancreatitis. The aim of the present study was to determine the effects of everolimus on blood biochemical parameters and tissue histopathology in an experimental rat model of cerulein-induced acute pancreatitis. Material and Methods:In 30 Wistar albino rats (male; 240-260 g), acute pancreatitis was induced by an intraperitoneal injection of cerulein (50 μg/kg) administered twice in 2 h. They were equally divided into the following three groups: 0.9% isotonic solution (Group 1; control), everolimus once (Group 2), and everolimus twice (Group 3) by oral gavage after cerulein injection. Thirty hours after the induction of pancreatitis, blood samples were collected by direct intracardiac puncture, rats were sacrificed, and pancreatic tissue samples were obtained.Results: Biochemical analyses of the blood samples showed statistically significant difference in red blood cell count as well as hemoglobin, hematocrit, urea, and alanine transaminase levels among the study groups (p<0.05 in all). Everolimus proved to significantly increase red blood cell count in a dose-independent manner. Hemoglobin and hematocrit levels significantly increased only after treatment with one dose of everolimus. Urea level was significantly different between the Groups 2 and 3; however, no change was observed in both groups when compared with the control. Alanine transaminase level significantly decreased only after treatment with two doses of everolimus. Histopathological analyses revealed that everolimus significantly decreased inflammation and perivascular infiltrate in a dose-dependent manner (35% in Group 2, 75% in Group 3; p=0.048). Conclusion:Treatment with two doses of everolimus improved some biochemical and histopathological parameters of experimental rat models of cerulein-induced acute pancreatitis and implied the specific inhibition of inflammatory response pathways. Keywords: Pancreatitis, cerulein, everolimus, inflammation INTRODUCTIONAcute pancreatitis is a localized inflammatory condition with a high mortality rate (2.1%-9.2%) worldwide. Because of its potential to trigger systemic inflammatory response, it can cause multiple organ failure (1, 2). The common causes of acute pancreatitis are alcohol abuse or gallstone disease (60%-75% of the cases) followed by hypertriglyceridemia, hyperparathyroidism, pancreatic malignancy, endoscopic retrograde cholangiopancreatography, trauma, infectious agents (increasingly associated with HIV infection), drugs (such as tetracycline, azathioprine, ethinyl estradiol, mercaptopurine, and sulfamethoxazole), autoimmunity, abdominal trauma, ischemia, diabetes mellitus, porphyria, and heredity (3-5).Although the disease is common, the treatment of acute pancreatitis is still very limited. There are only a number of pharmacological approaches, which are mostly supportive involving adequate fluid resuscitation and oxygen supplementation, to maintain normal art...

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of everolimus on a rat model of cerulein-induced experimental acute pancreatitis

Özkardeş¹,

Bozkurt²,

Dumlu³

et al. 2015

UCD

View full text Add to dashboard Cite

show abstract

“…La clínica de la PAE por hipercalcemia secundario al HPTP es todo un desafío diagnóstico ya que es de carácter inespecífica, con limitación de estudios complementarios de imagen junto con el hecho de diagnósticos ginecológicos alternativos como la hiperememesis gravídica, por lo que se requiere un alto índice de sospecha y un estudio de pesquisa sistemático para realizar un diagnóstico oportuno 12,13 .…”

Section: Discussionunclassified

Pancreatitis aguda por hipercalcemia en el embarazo. Caso clínico

Arnold

Martínez²,

Oksenberg

et al. 2019

Rev. méd. Chile

View full text Add to dashboard Cite

Acute pancreatitis due to hypercalcemia during pregnancy. Report of one case Acute pancreatitis during pregnancy is uncommon and usually associated with gallstones. However other etiologies must be considered. We report a 24 years old woman with a 32 weeks pregnancy consulting for abdominal pain, nausea and vomiting. She had elevated lipase and amylase levels, a corrected serum calcium of 13.1 mg/dl and a serum phosphate of 1.6 mg/dl. A magnetic resonance colangiopancreatography showed an enlarged pancreas with inflammatory changes and a normal Wirsung duct. A parathyroid nodule was found on cervical ultrasonography. The patient was treated initially with cinacalcet with partial response. A parathyroidectomy was performed at 39 weeks of pregnancy with a good maternal and fetal evolution. (Rev Med Chile 2019; 147: 1078-1081

show abstract

“…Hipertrigliseridemide açığa çıkan serbest yağ asitlerinin, pankreatik yatakta lizolesitin ile birlikte asiner hücrelerde ve mikrovasküler membranlarda hasara neden olarak pankreatit oluşturduğu düşünülmektedir. 4,5 Hastalarda amilaz düzeyi normal saptanabilir. Bu durumda serumun dilue edilerek çalışılması doğru tanıya ulaşmada yardımcı olmaktadır.…”

Section: Discussionunclassified

Akut Pankreatitte Atipik Prezentasyon: Normal Amilaz Düzeyi

Demirci¹,

Polat²,

Kantarcıoğlu³

et al. 2014

Ankara Med J

View full text Add to dashboard Cite

ÖzetAkut pankreatit, pankreas parankiminin inflamatuvar bir hastalığıdır. Klinik prezentasyona göre hafif (ödematöz) ve şiddetli (nekrotizan) pankreatit olarak iki gruba ayrılmaktadır. En sık etyolojik nedenler safra taşı ve alkoldür. Hipertrigliseridemi, akut non-biliyer pankreatitte nadir görülen bir etyolojik faktördür. Hipertrigliseridemiye bağlı oluşan akut pankreatit tablosunda amilaz normal seviyede saptanabilir Görüntüleme tetkikleri ve serum lipaz düzeyi tanıda yardımcıdır. Biz burada hipertrigliseridemiye sekonder olarak gelişen ve amilaz değeri normal olan akut pankreatit olgusunu sunuyoruz. Anahtar Kelimeler: Akut Pankreatit, hipertrigliseridemi, amilaz Abstract Acute pancreatitis is a paranchymal inflamatory disease of the pancreas. According to the clinical presentation, pancreatitis is divided into two groups; mild (edematous) and severe (necrotizing) pancreatitis. Gall stones and alcohol use are the most common etiologic reasons. Hypertriglyceridemia is a rare etiological factor in non-biliary pancreatitis. Serum amylase levels may be at normal ranges in acute pancreatitis due to hypertriglyceridemia. Radiological screening and serum lipase levels are helpful for diagnosis. Herein we present a case of acute pancreatitis secondary to hypertriglyceridemia with normal amylase values.

show abstract

Metabolic pancreatitis: Etiopathogenesis and management

Cited by 46 publications

References 50 publications

Effects of everolimus on a rat model of cerulein-induced experimental acute pancreatitis

Effects of everolimus on a rat model of cerulein-induced experimental acute pancreatitis

Pancreatitis aguda por hipercalcemia en el embarazo. Caso clínico

Akut Pankreatitte Atipik Prezentasyon: Normal Amilaz Düzeyi

Contact Info

Product

Resources

About