Metabolic parameter, bleeding, and weight changes in U.S. women using progestin only contraceptives

Mainwaring, Robin; Hales, Holly Ann; Stevenson, Kim; Hatasaka, Harry H.; Poulson, A. Marsh; Jones, Kirtly Parker; Peterson, Charles M.

doi:10.1016/0010-7824(95)00011-x

Cited by 77 publications

(37 citation statements)

References 20 publications

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“…As shown, our results are in good agreement with the result of Di Carlo et al regarding the NETA COC influence on adiponectin levels only. According to the results of present study, LD COCs affect the serum adiponectin, leptin and lipid levels, which is in agreement with some [23] but not all [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] studies. The biological pathways underlying COC alteration of adiponectin, leptin, lipid and lipoprotein production are not clear, but could include effects on maturation or synthesis of new molecules or might be a result of an increased frequency of a particular allele of these molecules.…”

Section: Discussionsupporting

confidence: 92%

“…Previous reports of Mainwaring et al [11] conducted on healthy women aged 16-43 years (98% Caucasian) were attended in the University of Utah Obstetrics and Gynecology Clinic for a clinical study examining metabolic parameters, menstruation disorders, and changes in weight after 12 months of use of a progestin-only contraceptive [Norplant contraceptive implants (No. 44)], Depo-Provera (No.…”

Section: Introductionmentioning

confidence: 99%

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Adiponectin, leptin and lipid profiles evaluation in oral contraceptive pill consumers

Fallah

Pour

Chadegani

et al. 2011

Arch Gynecol Obstet

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LD COC uptake results in a significant decrease in serum adiponectin concentration, nonsignificant increase in leptin levels and a more atherogenic lipid profile by significantly increasing LDL and nonsignificantly decreasing HDL concentrations. These findings suggested that COC may reduce or stimulate the adiponectin and leptin concentrations, respectively. This might be due to an effect of these pills on adipocyte maturation via inhibition or stimulation of the synthesis of new adiponectin and leptin molecules or may be a result of the increased frequency of a particular allele of the adiponectin and leptin. It is suggested that these alterations in adiponectin and leptin concentrations and lipid profiles may be related to their probable effects in response to various pathological and physiological properties of COC or its metabolites. It seems that probably free radicals produced during metabolism of COCs change the amounts of adipokines and atherogenic lipids.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Adiponectin, leptin and lipid profiles evaluation in oral contraceptive pill consumers

Fallah

Pour

Chadegani

et al. 2011

Arch Gynecol Obstet

View full text Add to dashboard Cite

show abstract

“…Few researchers have examined whether or not intake is affected when ovulation is suppressed with contraceptive hormones. Preliminary reports suggest that some newer contraceptive drugs, such as implanted (Norplant 1 ) and injected (DepoProvera 1 ) forms of progestin promote weight gain by increasing appetite (Berenson & Wiemann, 1995;Mainwaring et al, 1995). Previous studies also show that women report more food cravings than men and that among women, the most commonly craved food is chocolate (Weingarten & Elston, 1990).…”

mentioning

confidence: 92%

Reproductive hormones and eating behavior in young women

Pelkman

Heinbach

Rolls³

2000

Appetite

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“…[4][5][6] Published studies of weight changes among DMPA users are inconsistent. Some studies report no weight changes unique to DMPA users [7][8][9][10] while others find average weight gains as high as 9 kg in 2 y or less. 6,[11][12][13][14] Most of these studies have used either retrospective designs or did not include controls in the prospective design.…”

Section: Introductionmentioning

confidence: 99%

Weight, fat mass, and central distribution of fat increase when women use depot-medroxyprogesterone acetate for contraception

et al. 2005

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OBJECTIVE:To compare longitudinal changes in weight, body fat, and ratio of central to peripheral fat mass among first-time depot-medroxyprogesterone acetate (DMPA) users to women using no hormonal contraception, and to evaluate user characteristics associated with that change. DESIGN: Prospective longitudinal study. SUBJECTS: Healthy women, aged 18-35 y, using DMPA for contraception (n ¼ 178) and women using no hormonal contraception (n ¼ 145). MEASUREMENTS: Weight, body fat, and the central distribution of fat, measured at 3-month intervals for 30 months, by electronic scale and dual-energy X-ray absorptiometry (DEXA). The ratio of central to peripheral distribution of body fat was computed by dividing the body fat in the conventional DEXA trunk region of interest (ROI) by the ROI's that encompass the arms, hips and legs. RESULTS: Women using DMPA had a significantly greater increase in all measures of fatness than women using no hormonal method of contraception (Po0. In contrast, weight, fat mass and the ratio of central to peripheral fat mass of control participants remained virtually unchanged over the same time period. Women with higher baseline physical activity levels had a smaller increase in body fat (P ¼ 0.003) and the fat ratio (P ¼ 0.03), but not weight (P ¼ 0.48). No other user characteristics including, smoking, past oral contraceptive use or previous pregnancies predicted change in level of fatness. CONCLUSIONS: This study has demonstrated a change in body composition toward greater fatness and toward a central redistribution of fat among DMPA users as compared to controls and provides important information to be used when counseling women regarding contraceptive methods. Given the potential long-term implication of these changes, further study is recommended to determine whether the gains in fatness are reversed following DMPA discontinuation and to examine the role of progestins in the development and maintenance of obesity.

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Metabolic parameter, bleeding, and weight changes in U.S. women using progestin only contraceptives

Cited by 77 publications

References 20 publications

Adiponectin, leptin and lipid profiles evaluation in oral contraceptive pill consumers

Adiponectin, leptin and lipid profiles evaluation in oral contraceptive pill consumers

Reproductive hormones and eating behavior in young women

Weight, fat mass, and central distribution of fat increase when women use depot-medroxyprogesterone acetate for contraception

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