Metabolic predictors of individual immune responses to adaptogenic balneotherapy

Abstract

Background. Earlier four variants of the immune responses to adaptogenic balneotherapy have been identified. All four variants of immune responses are virtually unmistakably (with an accuracy of 97,7%) predicted by a set of 20 predictors including 12 immune blood parameters and one saliva parameter, 4 information parameters, 2 fecal microbiota parameters as well as erythrocyturia. In the next study discriminant analysis revealed that constellation 8 HRV and 5 Endocrine parameters as well as Gender of the patient predicts the nature of the immune response with an accuracy of 90,9%. The purpose of this study is to search for predictors of immune responses among the registered Metabolic parameters. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets' spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. We determined them the Electrokinetic index, Lipoproteines spectrum, plasma and daily urine levels of Electrolytes and Nitrous metabolites as well as basal and postprandial volume of gall-bladder. Results. Discriminant analysis revealed 16 parameters as the predictors. Of these, 3 reflect the level of Plasma Electrolytes, 5 -the Urine Electrolytes, another 2 -the levels of plasma and urine Urea. Other predictors were: Very Low Density Lipoprotein Cholesterol plasma level, Body Mass index, fasting gallbladder volume and 30 minutes after cholekinetics, Electrokinetic index, and patient Age. These predictors, taken together, determine the nature of the immune response with an accuracy of 95,5%. Conclusion. The variety of immune responses to adaptogenic balneotherapy is quite strictly conditioned by the initial state of the neuroendocrine-immune complex, microbiota, cholekinetics and metabolism, as well as the age and sex of patients.

Metabolic accompaniment of individual immune responses to chronic stress in female rats

“…In another observation, we found that the immune response to the antipode of stressors adaptogens is also individual in nature and is clearly conditioned by the constellation of initial parameters of the neuroendocrine-immune complex and metabolism [17][18][19][20][21].…”

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“…Other predictors were the following: very low density lipoprotein cholesterol plasma level, body mass index, fasting gallbladder volume and 30 minutes after cholekinetics, electrokinetic index and a patient's age. These predictors, taken together, determined the nature of the immune response with an accuracy of 95,5% [13].…”