Background. Earlier have been shown that the immune responses to course of drinking of Naftussya bioactive water from Truskavet's spa are ambiguous and individual. However, at Truskavets' spa water monotherapy is a rare exception for specific contingents, whereas the vast majority of patients use a balneotherapy complex: drinking of Naftussya, application of ozokerite and mineral baths. The immune responses to balneotherapeutic complex are also ambiguous which is a separate manifestation of the multivariate effects of balneological agents as well stressors on the body. Therefore, the purpose of this study is to analyze variants of immune responses to balneotherapeutic complex of Truskavets' spa. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets' spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. The survey was conducted twice, before and after balneotherapy (drinking Naftussya bioactive water three times a day, ozokerite applications, mineral baths every other day for 7-10 days). Immune status evaluated on a set of I and II levels recommended by the WHO. In portion of capillary blood we counted up Leukocytogram and calculated two variants of Adaptation Index as well as two variants of Strain Index by IL Popovych. We calculated also the Entropy of Immunocytogram and Leukocytogram. The condition of Microbiota is evaluated on the results of sowing of feces and urine. Results. Four variants of the immune responses to balneotherapeutic complex have been identified. In 40,9% of patients, initially normal immune status did not change significantly. In 31,8%, the lower boundary level of immunity is completely normalized. In 22,7% moderate immunosuppression is reduced, but not up to normal. However, in 4,5% of people, initially normal level of immunity are transformed into moderate immunosuppression. Discriminant analysis was conducted to identify exactly the parameters of the immunity and microbiota, in which the four immune response clusters differ significantly from each other. 24 parameters were characteristic, 12 of them related to the immune parameters of the blood, one of the saliva, 5 of the feces microbiota and 3 related to urinary syndrome as well as 4 parameters are information. The other 25 parameters were outside the discriminatory model. Conclusion.

Background. Earlier in clinical observations four variants of the immune responses to adaptogenic balneotherapy at the Truskavets' spa have been identified. In 40,9% of patients, initially normal immune status did not change significantly; in 31,8%, the lower boundary level of immunity is completely normalized; in 22,7% moderate immunosuppression is reduced, but not up to normal; however, in 4,5% of people, initially normal level of immunity are transformed into moderate immunosuppression. All four variants of immune responses are virtually unmistakably predicted by a set of 20 predictors. The purpose of this study is to analyze vegetative, endocrine and metabolic accompaniments of individual immune responses to balneofactors of Truskavets' spa. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets' spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. The survey was conducted twice, before and after balneotherapy (drinking bioactive water Naftussya three times a day, ozokerite applications, mineral baths every other day for 7-10 days). Immune status evaluated on a set of I and II levels recommended by the WHO. The state of the autonomic nervous system is estimated by HRV ("CardioLab+HRV"). To assess endocrine status we determined plasma levels of principal adaptation Hormones: Cortisol, Testosterone and Triiodothyronine (ELISA). We determined also the plasma and daily urine levels of the electrolytes: calcium, phosphates, sodium, potassium, magnesium and chloride as well as nitrous metabolites creatinine, urea and uric acid. According to the parameters of electrolyte exchange, parathyroid, calcitonin and mineralocorticoid hormonal activities was evaluated. We estimated also plasma lipide spectrum. Results. 13 immunosuppressive and 6 immuneenhancing neuro-endocrine and metabolic parameters identified. Discriminant analysis conducted to identify parameters, in which the four immune response clusters differ significantly from each other. 25 parameters are characteristic, 12 of them related to the HRV, 5 to endocrine, 5 to electrolytes and 3 to nitrous metabolites exchange. Conclusion. 208 Individual immune responses to adaptogenic balneofactors are accompanied by characteristic changes in the parameters of the autonomic nervous and endocrine systems, as well as the exchange of electrolytes, nitrogen metabolites and lipids.

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Background. Earlier four variants of the immune responses to adaptogenic balneotherapy have been identified. All four variants of immune responses are virtually unmistakably predicted by a set of 20 predictors including 12 immune blood parameters and one saliva parameter, 4 information parameters, 2 fecal microbiota parameters as well as erythrocyturia. The purpose of this study is to search for predictors of immune responses among the registered parameters of the autonomic nervous and endocrine systems. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets' spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. We determined them the HRV parameters and plasma levels of principal adaptation Hormones: Cortisol, Testosterone and Triiodothyronine. Results. Discriminant analysis revealed that constellation 8 HRV and 5 Endocrine parameters as well as Gender of the patient predicts the nature of the immune response with an accuracy of 90,9%. Conclusion. The previously revealed variety of immune responses to adaptogenic balneotherapy is quite strictly conditioned by the initial state of the neuroendocrine-immune complex and microbiota as well as the sex of patients.

Background. Earlier four variants of the immune responses to adaptogenic balneotherapy have been identified. All four variants of immune responses are virtually unmistakably (with an accuracy of 97,7%) predicted by a set of 20 predictors including 12 immune blood parameters and one saliva parameter, 4 information parameters, 2 fecal microbiota parameters as well as erythrocyturia. In the next study discriminant analysis revealed that constellation 8 HRV and 5 Endocrine parameters as well as Gender of the patient predicts the nature of the immune response with an accuracy of 90,9%. The purpose of this study is to search for predictors of immune responses among the registered Metabolic parameters. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets' spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. We determined them the Electrokinetic index, Lipoproteines spectrum, plasma and daily urine levels of Electrolytes and Nitrous metabolites as well as basal and postprandial volume of gall-bladder. Results. Discriminant analysis revealed 16 parameters as the predictors. Of these, 3 reflect the level of Plasma Electrolytes, 5 -the Urine Electrolytes, another 2 -the levels of plasma and urine Urea. Other predictors were: Very Low Density Lipoprotein Cholesterol plasma level, Body Mass index, fasting gallbladder volume and 30 minutes after cholekinetics, Electrokinetic index, and patient Age. These predictors, taken together, determine the nature of the immune response with an accuracy of 95,5%. Conclusion. The variety of immune responses to adaptogenic balneotherapy is quite strictly conditioned by the initial state of the neuroendocrine-immune complex, microbiota, cholekinetics and metabolism, as well as the age and sex of patients.