Metabolic profile and assessment of occupational arsenic exposure in copper- and steel-smelting workers in China

Shi, Xi; Zheng, Qing‐Shui; Zhang, Qiang; Sun, Guifan

doi:10.1007/s00420-010-0574-7

Cited by 22 publications

(19 citation statements)

References 31 publications

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“…Arsenic methylation indices were defined as the percentages of respective arsenic species in urine samples. Moreover, PMI was calculated as (MMA+DMA)/ TAs and SMI as DMA/(MMA+DMA) [27].…”

Section: Discussionmentioning

confidence: 99%

“…However, recent investigations suggest that MMA III and DMA III are more toxic than iAs arsenite [24,25]. Urinary arsenic speciation is typically used as an indicator of arsenic metabolism in evaluating arsenic methylation capacity [26] in terms of the primary methylation index (PMI, defined as (MMA+DMA)/total arsenic (TAs)) and secondary methylation index (SMI, defined as DMA/(MMA+DMA)) [20,27]. Numerous epidemiological studies have revealed that the risk of adverse health effects is associated with arsenic methylation capacity.…”

Section: Introductionmentioning

confidence: 99%

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Arsenic Metabolites and Methylation Capacity Among Individuals Living in a Rural Area with Endemic Arseniasis in Inner Mongolia, China

Wei

et al. 2015

Biol Trace Elem Res

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More than 0.3 million individuals are subject to chronic exposure to arsenic via their drinking water in Inner Mongolia, China. To determine arsenic methylation capacity profiles for such individuals, concentrations of urinary arsenic metabolites were measured for 548 subjects using high-performance liquid chromatography and a hydride generator combined with inductively coupled plasma-mass spectrometry. Mean urinary concentrations of dimethylarsonic acid (DMA), monomethylarsonic acid (MMA), inorganic arsenic (iAs), and total arsenic (TAs) were 200.50, 46.71, 52.96, and 300.17 μg/L, respectively. The %iAs, %DMA, and %MMA were 15.98, 69.72, and 14.29 %. Mean urinary %iAs and %MMA were higher in males, while urinary %DMA was higher in females. There was a strong positive correlation between %iAs and %MMA, with negative correlations between %iAs and %DMA, and %iAs and %MMA. In addition, %iAs and %MMA were positively associated with total arsenic in drinking water (WAs), while %DMA was negatively related with WAs. Regression analysis indicated that the primary methylation index (PMI) and secondary methylation index (SMI) generally decreased with increasing WAs. Females had a higher arsenic methylation capacity compared to males. Younger subjects had lower primary arsenic methylation capacity. However, the secondary arsenic methylation capacity was hardly affected by age. Moreover, both primary and secondary arsenic methylation capacities were negatively related to WAs.

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“…Arsenic methylation indices were defined as the percentages of respective arsenic species in urine samples. Moreover, PMI was calculated as (MMA+DMA)/ TAs and SMI as DMA/(MMA+DMA) [27].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Arsenic Metabolites and Methylation Capacity Among Individuals Living in a Rural Area with Endemic Arseniasis in Inner Mongolia, China

Wei

et al. 2015

Biol Trace Elem Res

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“…Dye production and use; clinical laboratories [220,247] Group 1 [76] 1 Not all of them are to be referred to group Non-infective risk As 7440-38-2 Timber manufacturing; pesticide use; As extraction industry; lead processing; pharmaceutical industry; glass industry; leather preservatives; antifouling paints; agrochemical production; microelectronics and optical industries; non-ferrous metal smelters; coal-fired power plants [254][255][256][257][258] Group 1 [263] Cd 7440-43-9 Cd mining; manufacturing of Cd-containing ores and products; Ni-Cd battery manufacturing, Cd alloy production [275,277,278] Group 1 [263] As: Arsenic; Cd: Cadmium; IARC: International Agency for Research on Cancer; CAS No. : Chemical abstract service number.…”

Section: -87-5mentioning

confidence: 99%

“…The workers in mechanical industries are exposed to the risk of illness from dyes, chemicals and glass [253][254][255][256][257][258] . After oral intake and gastrointestinal absorption, it is metabolized in the liver where it is conjugated with glutathione and methylated [259,260] .…”

Section: Arsenicmentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson's disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. Core tip: Hepatocellular carcinoma (HCC) is the fifth most common human cancer. This review summarizes current knowledge regarding the occupational risk factors of HCC. In particular, we underline not only the infective but also non-infective occupational risk exposure, including chemical agents and toxic metabolites which are a major cause of liver damage.

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“…However, occupational inhalation exposure to airborne arsenic remains a serious health issue in some localities. A recent study reported that copper smelter workers in northeastern China were exposed to airborne arsenic values that were up to 57% above the short-term exposure threshold limit value of 20 µg·m −3 [230]. Seven of the 38 copper smelter workers selected for investigation had arsenic-related skin disorders including hyperkeratosis and/or hyper-pigmentation, as well as elevated urinary arsenic levels [230].…”

Section: Known Occupational Exposuresmentioning

confidence: 99%

Health Effects Associated with Inhalation of Airborne Arsenic Arising from Mining Operations

et al. 2014

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Arsenic in dust and aerosol generated by mining, mineral processing and metallurgical extraction industries, is a serious threat to human populations throughout the world. Major sources of contamination include smelting operations, coal combustion, hard rock mining, as well as their associated waste products, including fly ash, mine wastes and tailings. The number of uncontained arsenic-rich mine waste sites throughout the world is of growing concern, as is the number of people at risk of exposure. Inhalation exposures to arsenic-bearing dusts and aerosol, in both occupational and environmental settings, have been definitively linked to increased systemic uptake, as well as carcinogenic and non-carcinogenic health outcomes. It is therefore becoming increasingly important to identify human populations and sensitive sub-populations at risk of exposure, and to better understand the modes of action for pulmonary arsenic toxicity and carcinogenesis. In this paper we explore the contribution of smelting, coal combustion, hard rock mining and their associated waste products to atmospheric arsenic. We also report on the current understanding of the health effects of inhaled arsenic, citing results from various toxicological, biomedical and epidemiological studies. This review is particularly aimed at OPEN ACCESSGeosciences 2014, 4 129 those researchers engaged in the distinct, but complementary areas of arsenic research within the multidisciplinary field of medical geology.Arsenic is the 20th most abundant element in the earth's crust and may be released into the atmosphere as a result of natural processes and anthropogenic activities [1]. Environmental arsenic is released via chemical and physical weathering processes, biological activity and volcanic emissions, while anthropogenic sources include mining, metal smelting and burning of coal. Annual global arsenic emissions are estimated to be 24,000 t [2], with around 60% originating from copper smelting and coal combustion alone [3]. In some urban and highly industrialized areas, less than 2% of the atmospheric arsenic inputs originate from natural sources [3].Emissions of arsenic-bearing particulate matter (PM) are of particular concern for human populations living in proximity to an emission source. Arsenic and inorganic arsenic compounds are classified as Group 1 carcinogens and are associated with cancers of the lung, bladder, kidney, skin, liver and prostate [2]. It should be noted that within the general population, inhalation is only considered a minor exposure pathway for inorganic arsenic compounds, and ingestion is considered the primary exposure pathway [2]. However, populations living in the vicinity of an arsenic emission source have an increased risk of additional exposure through inhalation of arsenic-contaminated particulates [4][5][6][7][8][9].Despite their substantial contribution to global atmospheric arsenic species, mining operations play an understudied role in the generation of contaminated dust and aerosols [10]. To identify some of the emerging ...

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Metabolic profile and assessment of occupational arsenic exposure in copper- and steel-smelting workers in China

Abstract: Release of As dust produced in crude ore extracting and smelting is the main pollution source of As in copper smelter plant. The methylation capacity of As decreases with the increase in As exposure level, and skin damage caused by As is associated with decreasing methylation capacity.

Cited by 22 publications

References 31 publications

Arsenic Metabolites and Methylation Capacity Among Individuals Living in a Rural Area with Endemic Arseniasis in Inner Mongolia, China

Arsenic Metabolites and Methylation Capacity Among Individuals Living in a Rural Area with Endemic Arseniasis in Inner Mongolia, China

Hepatocellular carcinoma and the risk of occupational exposure

Health Effects Associated with Inhalation of Airborne Arsenic Arising from Mining Operations

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