Metabolic Profile in Sons of Women with Polycystic Ovary Syndrome

Recabarren, Sergio E; Smith, Rosita; Ríos, Rafael; Maliqueo, Manuel; Echiburú, Bárbara; Codner, Ethel; Cassorla, Fernando; Rojas, Pedro Augusto Díaz; Sir-Petermann, Teresa

doi:10.1210/jc.2007-2256

Cited by 112 publications

(92 citation statements)

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“…These findings provide evidence that exposure to excess testosterone during fetal development not only disrupts testicular differentiation, leading to a reduced number of sperm cells and compromised Sertoli cell function (Recabarren et al 2008a, 2008b, Rojas-García et al 2010, but also disrupts the interface of the pituitary-gonadal axis. How these findings are enchained remains to be investigated.…”

Section: Effect Of Prenatal Testosterone Excess On Gonadal Testosteromentioning

confidence: 70%

“…Male offspring of PCOS mothers manifest metabolic disarrangements beginning at birth and culminating in altered lipid profile, insulin resistance and excess weight gain in adulthood (Recabarren et al 2008b). Adult male sheep exposed to excess testosterone manifest a significant reduction in the sperm count, scrotal circumference and sperm motility (Recabarren et al 2008a), an increased number of Sertoli cells and an altered expression of FSH receptors and TGFB1 and TGFB3 (Rojas-García et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Pituitary and testis responsiveness of young male sheep exposed to testosterone excess during fetal development

Recabarren¹,

Rojas-García²,

Einspanier³

et al. 2013

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Prenatal exposure to excess testosterone induces reproductive disturbances in both female and male sheep. In females, it alters the hypothalamus-pituitary-ovarian axis. In males, prenatal testosterone excess reduces sperm count and motility. Focusing on males, this study tested whether pituitary LH responsiveness to GNRH is increased in prenatal testosterone-exposed males and whether testicular function is compromised in the testosterone-exposed males. Control males (nZ6) and males born to ewes exposed to twice weekly injections of 30 mg testosterone propionate from days 30 to 90 and of 40 mg testosterone propionate from days 90 to 120 of gestation (nZ6) were studied at 20 and 30 weeks of age. Pituitary and testicular responsiveness was tested by administering a GNRH analog (leuprolide acetate). To complement the analyses, the mRNA expression of LH receptor (LHR) and that of steroidogenic enzymes were determined in testicular tissue. Basal LH and testosterone concentrations were higher in the testosterone-exposed-males. While LH response to the GNRH analog was higher in the testosterone-exposed males than in the control males, testosterone responses did not differ between the treatment groups. The testosterone:LH ratio was higher in the control males than in the testosterone-exposed males of 30 weeks of age, suggestive of reduced Leydig cell sensitivity to LH in the testosterone-exposed males. The expression of LHR mRNA was lower in the testosterone-exposed males, but the mRNA expression of steroidogenic enzymes did not differ between the groups. These findings indicate that prenatal testosterone excess has opposing effects at the pituitary and testicular levels, namely increased pituitary sensitivity to GNRH at the level of pituitary and decreased sensitivity of the testes to LH.

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Section: Effect Of Prenatal Testosterone Excess On Gonadal Testosteromentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Pituitary and testis responsiveness of young male sheep exposed to testosterone excess during fetal development

Recabarren¹,

Rojas-García²,

Einspanier³

et al. 2013

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“…Otra observación interesante que hemos podido establecer es que las alteraciones metabólicas preceden al hiperandrogenismo en las hijas de madres con SOP y que los rasgos bioquímicos del SOP debutan en etapa Tanner IV del desarrollo puberal con aumento de la testosterona y una hiperrespuesta de LH al test de análogo de GnRH 6 . Desde el punto de vista metabólico, las hijas de madres con SOP muestran bajas concentraciones de adiponectina (proteína sensibilizante a la insulina que se origina en el adipocito); y un aumento de las concentraciones de insulina y triglicéridos 5 , mientras que los hijos presentan sobrepeso desde la infancia y desarrollan RI a medida que se hacen más adultos 32 . Estos datos, en conjunto, sugieren que los hijos e hijas de madres con SOP constituyen un grupo de alto riesgo para desarrollar alteraciones metabólicas y reproductivas a lo largo de la vida.…”

Section: ¿Cómo Infl Uye El Embarazo Sobre El Sop?unclassified

Síndrome de ovario poliquístico y embarazo

et al. 2012

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Polycystic ovary syndrome (PCOS) is a common endocrine metabolic dysfunction closely associated with insulin resistance and obesity, which predisposes to pregnancy complications and prenatal programming of the offspring. The aim of this review is to report our experience in PCOS patients, caracterizada por oligo-ovulación e hiperandrogenismo, lo que compromete la función reproductiva de la mujer. Su etiología es incierta y se encuentra en estrecha asociación a la resistencia insulínica (RI), la que juega un papel preponderante en su fi siopatología y en las consecuencias metabólicas a largo plazo, entre las que destacan el desarrollo precoz de síndrome metabólico, diabetes tipo 2 y enfermedad cardiovascular 2 .Las manifestaciones clínicas del SOP son heterogéneas y varían de acuerdo a la edad de la paciente. Se ha propuesto que este trastorno acompañaría a la mujer durante toda la vida, pudiendo manifestarse desde etapas muy tempranas del desarrollo sexual hasta la senectud [3][4][5][6] . El SOP se caracteriza por presentar una morfología ovárica típica con múltiples folículos en crecimiento, aumento del estroma ovárico e hipersecreción de andrógenos, lo que sugiere que las alteraciones de la esteroidogénesis y de la foliculogénesis serían eventos centrales de este

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“…Knowledge of this interplay between genetic [30] and environmental influences [31,32] in the pathogenesis of the metabolic syndrome can lead to the development of screening protocols geared to the detection of an individual at high risk for the development of the condition. Such screening may help to identify and capture the victim of a potentially lethal cluster of metabolic abnormalities, at a potentially reversible or modifiable stage, or at a stage preceding the onset of full blown type 2 diabetes or cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome in Relatives of Patients with Type 2 Diabetes

Rizwan¹

2018

EMIJ

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Submit Manuscript | http://medcraveonline.com to the same physical measurements and blood testing as the index groups.Results: Of the 230 siblings enrolled, complete data was available for 197. Mean age of index sibling, (n=112) was 34 ± 10.7; referent: (n=85)35.7±10.5 (p=0.24). Of 230 spouses enrolled, complete data was available for 187 spouses-mean age of index spouse, (n=84), was 49.6±11.0; referent: (n=103) 48.7±9.3 (p=0.1). No significant association in overall prevalence of MS in sibling and spouse of individuals with DM2, versus sibling and spouse of non-diabetics was found. There was significant association of high waist circumference in both siblings [1.04(1.006-1.07)] and spouses [1.03(1.007-1.06)] of diabetics versus referents. Conclusion:Abdominal obesity needs to be an integral aspect of cardiovascular disease (CVD) risk assessment. Health care providers need to incorporate spousal history of CVD and DM2 when taking family history from presenting patient. Advice regarding lifestyle modification is best targeted at the couple together, even if one partner appears to be nondiseased. Keywords: Research ArticleEndocrinol Metab Int J 2018, 6(1): 00158 AbstractBackground: Type 2 diabetes and overweight and obesity rates have reached epidemic proportions. Metabolic syndrome (MS) constitutes a cluster of conditions characterized by abdominal obesity, dysglycemia and hypertension. There is a scarcity of data on metabolic parameters of nongenetically related family members of subjects with type 2 diabetes (DM2) in Pakistan. These members may well be sharing unhealthy lifestyles with their diabetic spouse. We aimed to estimate prevalence of MS in blood and non blood relatives of patients known to have DM2, presenting to the diabetes clinic.

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Metabolic Profile in Sons of Women with Polycystic Ovary Syndrome

Abstract: This study indicates that sons of PCOS women exhibit higher body weight from early infancy. In addition, insulin resistance became evident as the subjects got older, which may place them at risk for the development of type 2 diabetes and cardiovascular disease.

Cited by 112 publications

References 48 publications

Pituitary and testis responsiveness of young male sheep exposed to testosterone excess during fetal development

Pituitary and testis responsiveness of young male sheep exposed to testosterone excess during fetal development

Síndrome de ovario poliquístico y embarazo

Prevalence of Metabolic Syndrome in Relatives of Patients with Type 2 Diabetes

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