Metabolic profiling of human blood

Trifonova, Oxana P.; Lokhov, Petr G.; Archakov, Alexander I.

doi:10.18097/pbmc20146003281

Cited by 30 publications

(15 citation statements)

References 49 publications

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“…Similar results have been reported in other studies which applied the AHP method for groundwater potential zonation [4,140,141]. According to the AUC value obtained, the GIS-based AHP model's prediction accuracy could be accepted as satisfactory (0.6-0.7) [142]. However, this result can be improved by adding more wells, flow rates, and depth data.…”

Section: Validation Of Resultssupporting

confidence: 85%

“…In this study, freshwater potential zones in the SLPB were identified and analyzed with remote sensing, GIS, and Analytic Hierarchy Process (AHP) using seven thematic layers such as geology, lineament density, LULC, TWI, rainfall, drainage density, and Similar results have been reported in other studies which applied the AHP method for groundwater potential zonation [4,140,141]. According to the AUC value obtained, the GISbased AHP model's prediction accuracy could be accepted as satisfactory (0.6-0.7) [142]. However, this result can be improved by adding more wells, flow rates, and depth data.…”

Section: Discussionsupporting

confidence: 61%

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Delineation of Groundwater Potential Zones (GWPZs) in a Semi-Arid Basin through Remote Sensing, GIS, and AHP Approaches

Uc-Castillo

Cruz

Ramos-Leal

et al. 2022

Water

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Groundwater occurrence in semi-arid regions is variable in space and time due to climate patterns, terrain features, and aquifer properties. Thus, accurate delineation of Groundwater Potential Zones (GWPZs) is essential for sustainable water resources management in these environments. The present research aims to delineate and assess GWPZs in a semi-arid basin of San Luis Potosi (SLP), Mexico, through the integration of Remote Sensing (RS), Geographic Information System (GIS), and Analytic Hierarchy Process (AHP). Seven thematic layers (geology, lineament density, land use and land cover, topographic wetness index (TWI), rainfall, drainage density, and slope) were generated in raster format. After the AHP procedure and rank assignment, the thematic layers were integrated using the raster calculator to obtain the GWPZs map. The results indicated that 68.21% of the area is classified as low groundwater potential, whereas 26.30% is classified as moderate. Validation was done by assessing the water residence time data from 15 wells distributed in the study area. Furthermore, the Receiver Operating Characteristics (ROC) curve was obtained, indicating a satisfactory accuracy prediction (AUC = 0.677). This study provides valuable information for decision-makers regarding the conservation and sustainable management of groundwater resources.

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Section: Validation Of Resultssupporting

confidence: 85%

Section: Discussionsupporting

confidence: 61%

Delineation of Groundwater Potential Zones (GWPZs) in a Semi-Arid Basin through Remote Sensing, GIS, and AHP Approaches

Uc-Castillo

Cruz

Ramos-Leal

et al. 2022

Water

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“…The developed LDT is based on direct mass spectrometry of blood plasma, which has been widely used in metabolomics and, in particular, in the laboratory where LDTs were developed for the study of cancers [ 28 , 29 , 30 , 31 , 32 ], diabetes [ 33 ], and PD [ 34 ]. This type of mass spectrometry is characterized by a high processing speed and a relatively high reproducibility [ 35 , 36 , 37 ], which are important for the use of mass spectrometry in the clinic. The mass spectrometry data processing, like peak alignment and data standardization, was specially developed for high-resolution mass spectra and successfully used for many years in studies of blood plasma [ 29 , 38 ] and now is implemented in the LDT.…”

Section: Discussionmentioning

confidence: 99%

Holistic Metabolomic Laboratory-Developed Test (LDT): Development and Use for the Diagnosis of Early-Stage Parkinson’s Disease

et al. 2020

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A laboratory-developed test (LDT) is a type of in vitro diagnostic test that is developed and used within a single laboratory. The holistic metabolomic LDT integrating the currently available data on human metabolic pathways, changes in the concentrations of low-molecular-weight compounds in the human blood during diseases and other conditions, and their prevalent location in the body was developed. That is, the LDT uses all of the accumulated metabolic data relevant for disease diagnosis and high-resolution mass spectrometry with data processing by in-house software. In this study, the LDT was applied to diagnose early-stage Parkinson’s disease (PD), which currently lacks available laboratory tests. The use of the LDT for blood plasma samples confirmed its ability for such diagnostics with 73% accuracy. The diagnosis was based on relevant data, such as the detection of overrepresented metabolite sets associated with PD and other neurodegenerative diseases. Additionally, the ability of the LDT to detect normal composition of low-molecular-weight compounds in blood was demonstrated, thus providing a definition of healthy at the molecular level. This LDT approach as a screening tool can be used for the further widespread testing for other diseases, since ‘omics’ tests, to which the metabolomic LDT belongs, cover a variety of them.

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“…Кровьосновной переносчик низкомолекулярных веществ в организме, являющихся питательными веществами, гормонами, субстратами и продуктами биохимических реакций. Кровь омывает все ткани в организме, и в неё выделяются вещества в ответ на внешние или внутренние стимулы [19]. Метаболомные исследования проводят методом ЯМР-спектроскопии и масс-спектрометрии [20][21][22][23].…”

Section: происхождение метаболомного анализа кровиunclassified

Metabolomic blood test: purpose, implementation and interpretation of data

2017

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The human body is an open system that receives a variety of xenobiotics in the course of dietary route or respiration and in the form of the drugs. As a lump sum scores of toxic and potentially toxic substances are detected in a human body that significantly affect health and human lifespan. There are also thousands of diseases, dozens of which latently occur in the body of each person. Traditional diagnosis is not able to screen all the variety of xenobiotics and potential human diseases. For this purpose metabolomic blood test is available which is of non-targeted (review) nature. The test can reveal all the diversity of low molecular weight substances in blood, including tens of thousands of xenobiotics and markers of different diseases. Detection of xenobiotics in the blood, directional detoxification and subsequent monitoring of "body's chemical purity" together with the control of "normality" of all biochemical processes in the organism, using metabolomics blood tests is a necessary and presumably a sufficient condition in the implementation of inherent human genotype longevity. This article describes the purpose, implementation and interpretation of metabolomic blood test facilitating the implementation of this method in the Russian Federation, in order to significantly increase the average life expectancy.

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Metabolic profiling of human blood

Cited by 30 publications

References 49 publications

Delineation of Groundwater Potential Zones (GWPZs) in a Semi-Arid Basin through Remote Sensing, GIS, and AHP Approaches

Delineation of Groundwater Potential Zones (GWPZs) in a Semi-Arid Basin through Remote Sensing, GIS, and AHP Approaches

Holistic Metabolomic Laboratory-Developed Test (LDT): Development and Use for the Diagnosis of Early-Stage Parkinson’s Disease

Metabolomic blood test: purpose, implementation and interpretation of data

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