Metabolic regulation in the immune response to cancer

Wu, Qi; Yu, Xin; Li, Juanjuan; Sun, Shengrong; Tu, Yi

doi:10.1002/cac2.12182

Cited by 29 publications

(24 citation statements)

References 291 publications

(378 reference statements)

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“…These immune cells obviously adapt to the regional environment and show metabolic characteristics analogous to those of resident tissue. 171 , 172 In parallel, several immune cell subsets and multitudinous immunological factors dynamically exist in circulation and migrate throughout the body to conduct immunosurveillance. When at rest, these immune cells commonly need few nutrients.…”

Section: Nutrient-associated Molecular Mechanismsmentioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound nutritional therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.

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Section: Nutrient-associated Molecular Mechanismsmentioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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“…Aging is a major problem facing mankind, and the pursuit of immortality is an eternal topic [111][112][113][114]. After more and more studies, mesenchymal stem cells have been found to play a great role in combating aging.…”

Section: The Anti-aging Effect Of Mscsmentioning

confidence: 99%

Mesenchymal stem cells: ideal seeds for treating diseases

Gao

Fan

et al. 2021

Human Cell

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Mesenchymal stem cells (MSCs), a kind of multipotent stem cells with self-renewal ability and multi-differentiation ability, have become the "practical stem cells" for the treatment of diseases. MSCs have immunomodulatory properties and can be used to treat autoimmune diseases, such as systemic lupus erythematosus (SLE) and Crohn's disease. MSCs also can be used in cancer and aging. At present, many clinical experiments are using MSCs. MSCs can reduce the occurrence of inflammation and apoptosis of tissue cells, and promote the proliferation of endogenous tissue and organ cells, so as to achieve the effect of repairing tissue and organs. MSCs presumably also play an important role in Corona Virus Disease 2019 (COVID-19) infection. Keywords Mesenchymal stem cells • Autoimmune diseases • Aging • Inflammation • Cancer • COVID-19 Abbreviations AA Alginate ARDS Acute respiratory distress syndrome BM-MSCs Bone marrow mesenchymal stem cells BMP-2 Bone morphogenetic protein 2 CBX4 Chromobox protein homologue 4 CRISPR Clustered Regularly Interspaced Short Palindromic Repeats Cas9 CRISPR-associated protein-9 nuclease Col Collagen COPD Chronic obstructive pulmonary disease COVID-19 Corona Virus Disease 2019 CRC Colorectal cancer CXCR7 C-X-C chemokine receptor type 7 CXCL12 C-X-C motif chemokine ligand 12

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“…In this way, onco-spheres can be classified among niches where tumor initiates, expands and spreads, namely the primary, regional (lymph nodes), distal (pre/postmetastatic) as well as systemic onco-spheres accordingly (Figure 1). Employing the principles of ecology, cancer cells act as the emerging species that employ different metabolic and reproductive strategies to hijack resources and space from the existing host cells, evade/defense predation by the host immunity, and cooperate to disperse throughout the circulation, followed by co-evolution with new oncospheres and end up colonizing as macroscopic outgrowths [8]. Three essential factors are critical for the onco-sphere formation: energy source, microenvironment, and interactive network.…”

Section: Introductionmentioning

confidence: 99%

The theory of tumor ecosystem

Chen

Song

2022

Cancer Communications

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Cancer cells can be conceived as "living organisms" interacting with cellular or non-cellular components in the host internal environment, not only the local tumor microenvironment but also the distant organ niches, as well as the immune, nervous and endocrine systems, to construct a self-sustainable tumor ecosystem. With increasing evidence for the systemic tumor-host interplay, we predict that a new era of cancer therapy targeting the ecosystemic vulnerability of human malignancies has come. Revolving around the tumor ecosystem scoped as different hierarchies of primary, regional, distal and systemic onco-spheres, we comprehensively review the tumor-host interaction among cancer cells and their local microenvironment, distant organ niches, immune, nervous and endocrine systems, highlighting material and energy flow with tumor ecological homeostasis as an internal driving force. We also substantiate the knowledge of visualizing,

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Metabolic regulation in the immune response to cancer

Cited by 29 publications

References 291 publications

Dietary regulation in health and disease

Dietary regulation in health and disease

Mesenchymal stem cells: ideal seeds for treating diseases

The theory of tumor ecosystem

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