Metabolic regulation of magnolol on the nuclear receptor, liver X receptor

Xie, Na; Hu, Chunyang; Guo, Anran; Liang, Hao; Du, Pengcheng; Yin, Guotian

doi:10.3892/etm.2015.2300

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…Liver X receptors (LXR) participate in the regulatory processes of many physiological activities, including metabolism of glucose, cholesterol, and fat. It has been demonstrated that magnolol can combine with LXR α dose-dependently and regulate its downstream genes expression in HepG2 and THP-1 cell lines [88]. High-fat diet (HFD) consumption has been linked to activation of hepatic steatosis and liver dysfunction.…”

Section: Metabolism-regulating Activitymentioning

confidence: 99%

Insights on the Multifunctional Activities of Magnolol

Zhang

Chen

Huang

et al. 2019

BioMed Research International

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Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated from Magnolia officinalis, has been extensively documented and shows a range of biological activities. Many signaling pathways include, but are not limited to, NF-κB/MAPK, Nrf2/HO-1, and PI3K/Akt pathways, which are implicated in the biological functions mediated by magnolol. Thus, magnolol is considered as a promising therapeutic agent for clinic research. However, the low water solubility, the low bioavailability, and the rapid metabolism of magnolol dramatically limit its clinical application. In this review, we will comprehensively discuss the last five-year progress of the biological activities of magnolol, including anti-inflammatory, antimicroorganism, antioxidative, anticancer, neuroprotective, cardiovascular protection, metabolism regulation, and ion-mediating activity.

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Section: Metabolism-regulating Activitymentioning

confidence: 99%

Insights on the Multifunctional Activities of Magnolol

Zhang

Chen

Huang

et al. 2019

BioMed Research International

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“…Recently, magnolol has emerged as an effective and safe feed additive to enhance health and growth in livestock production. Dietary magnolol supplementation in chickens has been reported to enhance growth performance [ 23 ], exert anti-inflammatory and antioxidant effects [ 24 , 25 ], increase villus height [ 26 ], promote intestinal barrier function [ 27 ], and regulate glucose and lipid metabolism [ 28 ]. Despite sharing common characteristics with other polyphenols, the potential of magnolol to regulate AA transporters and thereby enhance the absorption or deposition of AAs to promote animal growth remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Magnolol Supplementation Alters Serum Parameters, Immune Homeostasis, Amino Acid Profiles, and Gene Expression of Amino Acid Transporters in Growing Pigs

Liu,

Li,

et al. 2023

IJMS

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This study investigated whether dietary supplementation with magnolol affects growth performance, anti-inflammatory abilities, serum and muscle amino acid profiles, and metabolisms in growing pigs. A total of 42 seventy-days-old growing barrows (Duroc × Landrace × Yorkshire) were randomly allocated into two dietary groups: Con, control group (basal diet); and Mag, magnolol group (basal diet supplemented with 400 mg/kg of magnolol). The results revealed that dietary supplementation with magnolol had no effect (p > 0.05) on growth performance. However, magnolol supplementation remarkably increased (p < 0.05) the serum content of albumin, total protein, immunoglobulin G, immunoglobulin M, and interleukin-22. In addition, dietary magnolol supplementation altered the amino acid (AA) profiles in serum and dorsal muscle and particularly increased (p < 0.05) the serum content of arginine and muscle glutamate. Simultaneously, the mRNA expression of genes associated with AA transport in jejunum (SLC38A2, SLC1A5, and SLC7A1) and ileum (SLC1A5 and SLC7A1) was higher (p < 0.05) in the Mag group than in the Con group. Additionally, the serum metabolomics analysis showed that the addition of magnolol significantly enhanced (p < 0.05) arginine biosynthesis, as well as D-glutamine and D-glutamate metabolism. Overall, these results suggested that dietary supplementation with magnolol has the potential to improve the accumulation of AAs, protein synthesis, immunity, and body health in growing pigs by increasing intestinal absorption and the transport of AAs.

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“…), belongs to dampness removing drugs in TCM theory [ 10 ]. Recent pharmacological analysis have pointed out that MC has the effects of anxiolytic-like [ 11 ], apoptosis-inducing and antitumor [ 12 ], antimicrobial against multi-drug resistant Staphylococcus aureus [ 13 ], as well as lipid metabolism regulation [ 14 ]. Although previous studies have shown that MC can alleviate cisplatin-induced sarcopenia through immune regulation and inhibiting the expression of inflammatory cytokines [ 9 ], the specific active components, cellular and molecular mechanisms remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of magnoliae cortex on treating sarcopenia explored by GEO gene sequencing data combined with network pharmacology and molecular docking

et al. 2022

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Background Administration of Magnoliae Cortex (MC) could induce remission of cisplatin-induced sarcopenia in mice, however, whether it is effective on sarcopenia patients and the underlying mechanisms remain unclear. Methods Sarcopenia related differentially expressed genes were analysed based on three Gene Expression Omnibus (GEO) transcriptome profiling datasets, which was merged and de duplicated with disease databases to obtain sarcopenia related pathogenic genes. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were than performed to analyse the role of proteins encoded by sarcopenia related pathogenic genes and the signal regulatory pathways involved in. The main active components and target proteins of MC were obtained by searching traditional Chinese medicine network databases (TCMSP and BATMAN-TCM). MC and sarcopenia related pathogenic genes shared target proteins were identified by matching the two. A protein–protein interaction network was constructed subsequently, and the core proteins were filtered according to the topological structure. GO and KEGG analysis were performed again to analyse the key target proteins and pathways of MC in the treatment of sarcopenia, and build the herbs-components-targets network, as well as core targets-signal pathways network. Molecular docking technology was used to verify the main compounds-targets. Results Sarcopenia related gene products primarily involve in aging and inflammation related signal pathways. Seven main active components (Anonaine, Eucalyptol, Neohesperidin, Obovatol, Honokiol, Magnolol, and beta-Eudesmol) and 26 target proteins of MC-sarcopenia, of which 4 were core proteins (AKT1, EGFR, INS, and PIK3CA), were identified. The therapeutic effect of MC on sarcopenia may associate with PI3K-Akt signaling pathway, EGFR tyrosine kinase inhibitor resistance, longevity regulating pathway, and other cellular and innate immune signaling pathways. Conclusion MC contains potential anti-sarcopenia active compounds. These compounds play a role by regulating the proteins implicated in regulating aging and inflammation related signaling pathways, which are crucial in pathogenesis of sarcopenia. Our study provides new insights into the development of a natural therapy for the prevention and treatment of sarcopenia.

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Metabolic regulation of magnolol on the nuclear receptor, liver X receptor

Cited by 6 publications

References 20 publications

Insights on the Multifunctional Activities of Magnolol

Insights on the Multifunctional Activities of Magnolol

Magnolol Supplementation Alters Serum Parameters, Immune Homeostasis, Amino Acid Profiles, and Gene Expression of Amino Acid Transporters in Growing Pigs

Mechanisms of magnoliae cortex on treating sarcopenia explored by GEO gene sequencing data combined with network pharmacology and molecular docking

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