Metabolic restriction of cancer cells in vitro causes karyotype contraction—an indicator of cancer promotion?

Liu, Ying; Héroux, Paul; Kyrychenko, Igor

doi:10.1007/s13277-011-0262-6

Cited by 5 publications

(14 citation statements)

References 71 publications

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“…Seventy-five percent of the cells have just two chromosome numbers, 62 and 61, compared to a wider range under 21% oxygen (Li et al, 2012). The stability of chromosome numbers in baseline anoxic K562 has been periodically confirmed in our laboratory over 5 years.…”

Section: Resultsmentioning

confidence: 57%

“…Previous experiments (Li et al, 2012) on the five cancer cell lines used in this article show a link between metabolic restriction and KC. Anoxia alone induces partial KCs of 6-8 chromosomes.…”

Section: Mf and Oligomycinmentioning

confidence: 67%

“…The suppression of DNA synthesis, part of AMPK's catabolic control, leads to KCs through suppression of chromosome endoreduplication, the mechanism probably responsible for rapid chromosome number increases in cancer cells (Li et al, 2012).…”

Section: Kc Ampk and Diabetesmentioning

confidence: 99%

“…Our cells are also hyperploid, displaying a range of chromosomes numbers larger than 46, as a result of the enhanced metabolism typical of cancer cells. The absence of oxygen reduces chromosome numbers to some extent, but not back to normal, and also narrows their range (Li et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…KC is a rapid and reversible loss of chromosomes resulting from metabolic restriction (Li et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Extra-low-frequency magnetic fields alter cancer cells through metabolic restriction

Héroux

2013

Electromagnetic Biology and Medicine

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Section: Resultsmentioning

confidence: 57%

Section: Mf and Oligomycinmentioning

confidence: 67%

Section: Kc Ampk and Diabetesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…KC is a rapid and reversible loss of chromosomes resulting from metabolic restriction (Li et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Extra-low-frequency magnetic fields alter cancer cells through metabolic restriction

Héroux

2013

Electromagnetic Biology and Medicine

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Overcoming Hypoxia-Restrained Radiotherapy Using an Erythrocyte-Inspired and Glucose-Activatable Platform

et al. 2020

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Radiotherapy (RT) as one of the most powerful cancer treatment strategies has been greatly restricted by tumor hypoxia. A mounting effort has been devoted to develop oxygen delivery systems for boosting the RT effect. Unluckily, those systems only supplied modest oxygen, which could not afford more than once and long-time RT. Herein, we describe the development of a glucose-regulated drug release platform, allowing for a long-term tumor normoxic microenvironment and repeated RT for a long time. The repeated cycles resulted in sustained high Endostar plasma levels, which dramatically normalized the tumor vasculature and chronically reversed tumor hypoxia. Taking advantage of the inexhaustible supply of oxygen, Endo@GOx-ER enabled RT achieved an impressive cancer treatment output. To the best of our knowledge, our strategy is the initial attempt to overcome tumor-hypoxia-limited RT through the normalization of tumor vasculature by using an erythrocyte-inspired and glucose-activatable platform and it visually casts a light on the clinical development.

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Explore association of genes in PDL1/PD1 pathway to radiotherapy survival benefit based on interaction model strategy

Shen

Liu

et al. 2021

Radiat Oncol

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Purpose To explore the association of genes in “PD-L1 expression and PD-1 check point pathway in cancer” to radiotherapy survival benefit. Methods and materials Gene expression data and clinical information of cancers were downloaded from TCGA. Radiotherapy survival benefit was defined based on interaction model. Fast backward multivariate Cox regression was performed using stacking multiple interpolation data to identify radio-sensitive (RS) genes. Results Among the 73 genes in PD-L1/PD-1 pathway, we identified 24 RS genes in BRCA data set, 25 RS genes in STAD data set and 20 RS genes in HNSC data set, with some crossover genes. Theoretically, there are two types of RS genes. The expression level of Type I RS genes did not affect patients' overall survival (OS), but when receiving radiotherapy, patients with different expression level of Type I RS genes had varied survival benefit. Oppositely, Type II RS genes affected patients' OS. And when receiving radiotherapy, those with lower OS could benefit a lot. Type II RS genes in BRCA had strong positive correlation and closely biological interactions. When performing cluster analysis using these related Type II RS genes, patients could be divided into RS group and non-RS group in BRCA and METABRIC data sets. Conclusions Our study explored potential radio-sensitive biomarkers of several main cancer types in an important tumor immune checkpoint pathway and revealed a strong association between this pathway and radiotherapy survival benefit. New types of RS genes could be identified based on expanded definition to RS genes.

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Metabolic restriction of cancer cells in vitro causes karyotype contraction—an indicator of cancer promotion?

Cited by 5 publications

References 71 publications

Extra-low-frequency magnetic fields alter cancer cells through metabolic restriction

Extra-low-frequency magnetic fields alter cancer cells through metabolic restriction

Overcoming Hypoxia-Restrained Radiotherapy Using an Erythrocyte-Inspired and Glucose-Activatable Platform

Explore association of genes in PDL1/PD1 pathway to radiotherapy survival benefit based on interaction model strategy

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