Metabolic shifts in residual breast cancer drive tumor recurrence

Havas, Kristina M.; Milchevskaya, Vladislava; Radic, Ksenija; Alladin, Ashna; Kafkia, Eleni; García, Marta; Stolte, Jens; Klaus, Bernd; Rotmensz, Nicole; Gibson, Toby J.; Burwinkel, Barbara; Schneeweiß, Andreas; Pruneri, Giancarlo; Patil, Kiran Raosaheb; Sotillo, Rocı́o; Jechlinger, Martin

doi:10.1172/jci89914

Cited by 142 publications

(140 citation statements)

References 47 publications

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“…This metabolic change is modulated by oncogenic signaling pathways and promotes tumor initiation and progression, since cellular growth is dependent on the sustained availability of lipids (33). Moreover, metabolic shifts in lipid metabolism drive tumor recurrence after therapeutic intervention (34). Alterations in de novo lipid biosynthesis are associated with cancer pathogenesis (35).…”

Section: Discussionmentioning

confidence: 99%

Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells

Rodrigues

Correia

Mensurado

et al. 2018

Cancer Immunology Research

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Section: Discussionmentioning

confidence: 99%

Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells

Rodrigues

Correia

Mensurado

et al. 2018

Cancer Immunology Research

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“…A higher degree of oxidative stress (OS) may be responsible for damages to nucleic acids, proteins and lipids, thus affecting cellular signaling pathways . Possible involvement of OS in the recurrence of BC has been suggested . Taken together, it is assumed that protein markers involved in lipid metabolism might serve as a therapeutic target in lowering risks of recurrence in patients with BC.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of fatty acid binding protein‐4 in the invasive ductal carcinoma of the breast

Cui

Song

Kim

2019

Pathology International

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We conducted this study to identify clinico‐pathologic and prognostic factors that are associated with fatty acid binding protein‐4 (FABP4) and to discuss its therapeutic potentials in patients with breast cancer (BC). In a total of 75 patients with an established diagnosis of invasive ductal carcinoma of the breast, we performed a retrospective analysis of the medical records and analyzed their immunohistochemical findings. Following evaluation of baseline and clinico‐pathological characteristics such as the age, immunohistochemical expressions of FABP4, TNM stage, tumor grade, lymphatic and perineural invasion, estrogen receptor (ER) and progesterone receptor (PR), disease‐free survival (DFS), overall survival (OS), recurrence and death, we analyzed correlations of the expression of FABP4 with clinico‐pathologic and prognostic factors. Our results showed that tumor grade and recurrence had a significant correlation with the expression of FABP4 (P = 0.002 and 0.049, respectively). Moreover, we also found that the DFS had a significant correlation with the expression of FABP4 (P = 0.049). It can therefore be concluded that the expression of FABP4 might have a prognostic value in patients with BC. But further studies are warranted to establish its potentials as a prognostic indicator.

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“…The progression of the field towards the cultivation of primary mammary cells [10,11] and the advantages compared to work with cell-lines was discussed. Lastly, Dr. Jechlinger highlighted the importance of analysing tumour progression in the appropriate 3D cellular context and the possibility of doing so with primary mammary cells using approaches that show good correlation with in vivo results from the parental mouse model [12].…”

Section: Day Threementioning

confidence: 99%

See One, Do One, Teach One: A Practical Course on Methods in Mammary Gland Biology

Jechlinger

Kendrick

Smalley

et al. 2017

J Mammary Gland Biol Neoplasia

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The first EMBO Practical Course on "Techniques for Mammary Gland Research" took place at EMBL, Heidelberg, from the 20th -24th March 2017. The general aim of this practical and theory course was to ensure that all participants had the opportunity to learn about and practice some of the classical assays for studying mammary gland biology and tumorigenesis and also to enjoy some of the latest state-ofthe-art technology within the imaging facilities at EMBL. Specific goals for the course were to describe, demonstrate and practice key techniques for studying human and mouse mammary gland biology, with special emphasis on discussing both systems in the context of analysis of stem/progenitor cell populations. The course hosted 20 participants from 15 different countries, providing an additional excellent opportunity for scientific exchange and networking. Day OneOur first day's events were all located at the excellent ISG Hotel. Having made ourselves comfortable, we were briefed on how the course would work by Jacqueline Dreyer-Lamm, from EMBL. Dr. Maria Vivanco from CIC bioGUNE, Bilbao, introduced the course and its origins as an extension of the Workshop that the European Network of Breast Development and Cancer Labs (ENBDC, http://www.enbdc .org) organises every year in Weggis, Switzerland. It was the intention of this practical course to compliment the Weggis meeting, which is dedicated to oral presentations with a focus on methodology.We were then fortunate enough to have Professor Nancy Hynes from the Friedrich Miescher Institute for Biomedical Research, Basel, as a guest speaker. Prof. Hynes gave an inspiring overview of her career in breast cancer research, with a particular focus on the importance of novel methodological approaches in making breakthrough discoveries.

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Metabolic shifts in residual breast cancer drive tumor recurrence

Cited by 142 publications

References 47 publications

Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells

Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells

Prognostic significance of fatty acid binding protein‐4 in the invasive ductal carcinoma of the breast

See One, Do One, Teach One: A Practical Course on Methods in Mammary Gland Biology

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