Metabolic stress of pregnant sheep at the closing dates of pegnancy as a factor of  eclampsia development

Sengaliev, E. M.; Авдеенко, В.С.; Molchanov, A.V.

doi:10.18286/1816-4501-2018-2-206-209

Cited by 2 publications

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“…According to recent studies [1,2], eclampsia in pregnant sheep in the last stages of gestation develops as a result of disruption of the uteroplacental and fetal placental blood flow and changes in the coagulation properties of the blood, leading to placental insufficiency. The analysis of studies [3,4] on the cause-and-effect relationships of this disease indicates the polyhedral nature of the occurrence and course of eclampsia in small ruminant cattle in the last stages of gestation, during lambing and in the first days after birth. The obtained genetic data [5] indicate the incompatibility of fetal and maternal antigens and insufficient immunological changes that are necessary for the normal intrauterine development of the fetus/fetuses and their placenta.…”

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confidence: 99%

The morphofunctional state of pregnant sheep in the last stages of gestation is normal and with symptoms of eclampsia

Bulatov,

Avdeenko

2024

BIO Web Conf.

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Sheep in the last stages of pregnancy showed signs of eclampsia, such as proteinuria, hypertension, swelling of the abdominal wall, and coma. Based on the diagnoses, two groups of 20 sheep with eclampsia were created: typical and atypical signs, in each, and one group of clinically healthy animals. From each group, 5 animals were slaughtered. In sheep suffering from eclampsia, a decrease in the total mass of the placenta and its cotyledons, as well as an increase in the length of the umbilical cord, was also found. Standard histological and histochemical studies were performed on the obtained placental samples. As a result, it was found that the average thickness of the integumentary epithelium of the caruncles in ewes with a typical form of eclampsia was 14.3 ± 1.7 μm, and in sheep with an atypical form - 15.5 ± 1.9 μm, compared with 27.9 ± 1 .9 µm in the physiological course of gestation. This leads to a general decrease in the thickness of the layers of connective tissue separating the crypt and villi of the cotyledons. In addition, the cytoplasm of cells exhibits dystrophic modifications along with a decrease in the ability to store glycogen. Dystrophic changes are present in the cytoplasm of cells, which contributes to a decrease in glycogen storage.

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Section: Introductionmentioning

confidence: 99%

The morphofunctional state of pregnant sheep in the last stages of gestation is normal and with symptoms of eclampsia

Bulatov,

Avdeenko

2024

BIO Web Conf.

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Identification of clinical and biochemical markers of various forms of eclampsia in pregnant ewes

Plemyashov

Авдеенко

Bulatov

2023

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The clinical picture of the manifestation of various forms of eclampsia in pregnant ewes has been established, signs of a mild form of eclampsia in pregnant ewes are depression of the central nervous system. During the movements, the sheep staggered, the gait was uncertain. Quite often, there was a frozen pose, the animals stood with their necks outstretched and their heads held high. Characteristic signs of severe form are fibrillary twitching of the muscles of the ears, neck, and around the mouth. During the whole time, the animal was in a state of catalepsy. The sheep was lying on its side 8... 10 hours before its death, its limbs and neck were stretched out; it tried to throw its head back. Nervous excitement turned into a comatose state. Laboratory blood tests have established an increase in the level of ketone bodies above physiological limits by 2.3 times and their fractions — AcAs and HH, respectively, by 5.9 times and 1.5 times, a decrease in buffer bases to 18.41 ± 1.53 mmol/l, glucose concentration to 2.25±0.16 mmol/l, as well as the HH/AcAs coefficient to 1.53. The conducted ELISA of blood serum allowed us to obtain information about the levels of FSH, LH, etch radial values in the group of sheep with eclampsia and the control group, which significantly differed from each other (p<0.05). The content of cortisol (21.4±3.47 ng/ml), as well as progesterone (11.2± 4.31 ng/ml) remains quite significant, which does not allow for metabolic processes. In the blood of ewes with eclampsia, an increase in the concentration of ketodiene intermediates and conjugated trines was found to be 1.75 times, and the content of manol dialdehyde was 1.125±0.34 mmol/l. An integrated approach to the examination of pregnant ewes in the framework of obstetric medical examination increases the diagnostic effectiveness of eclampsia detection by 24.3% compared to traditional research methods. The diagnostic sensitivity was 75.8%, the specificity of the test was 96.2%, the prognostic value of a positive result was 94.5%, and the prognostic value of a negative result was 83.9%.>˂0.05). The content of cortisol (21.4±3.47 ng/ml), as well as progesterone (11.2± 4.31 ng/ml) remains quite significant, which does not allow for metabolic processes. In the blood of ewes with eclampsia, an increase in the concentration of ketodiene intermediates and conjugated trines was found to be 1.75 times, and the content of manol dialdehyde was 1.125±0.34 mmol/l. An integrated approach to the examination of pregnant ewes in the framework of obstetric medical examination increases the diagnostic effectiveness of eclampsia detection by 24.3% compared to traditional research methods. The diagnostic sensitivity was 75.8%, the specificity of the test was 96.2%, the prognostic value of a positive result was 94.5%, and the prognostic value of a negative result was 83.9%.

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Metabolic stress of pregnant sheep at the closing dates of pegnancy as a factor of eclampsia development

Cited by 2 publications

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The morphofunctional state of pregnant sheep in the last stages of gestation is normal and with symptoms of eclampsia

The morphofunctional state of pregnant sheep in the last stages of gestation is normal and with symptoms of eclampsia

Identification of clinical and biochemical markers of various forms of eclampsia in pregnant ewes

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