Metabolic studies on pentachlorophenol (PCP) in rats

Abstract

1. The metabolism of pentachlorophenol in rats was studied. 2. Metabolites isolated from rat urine and identified were: 2,3,4,5-tetrachlorophenol, 2,3,4,6-tetrachlorophenol, 2,3,5,6-tetrachlorophenol, tetrachlorocatechol, tetrachlororesorcinol, trichlorohydroquinone, tetrachlorohydroquinone, and traces of trichloro-1,4-benzoquinone, and tetrachloro-1,4-benzoquinone.

Identification of differential hepatic proteins in rare minnow (Gobiocypris rarus) exposed to pentachlorophenol (PCP) by proteomic analysis

“…PCP is a pow-erful uncoupler of oxidative phosphorylation. In current reports it suggested that tetrachlorohydroquinone (TCHQ), as a metabolite of PCP in liver (Juhl et al, 1985;Renner and Hopfer, 1990), may enhance toxicity and carcinogenicity of PCP, since it is capable of inducing oxidative damage (Wang and Lin, 1995). The mechanisms of toxicity induced by PCP to mammals and humans have been studied in vivo and in vitro (Chen et al, 2004).…”

Pentachlorophenol and Other Chlorinated Phenols Are Substrates for Human Hydroxysteroid Sulfotransferase hSULT2A1

“…In these studies, the unchanged parent molecule and its glucuronide and sulfate conjugates are found, as well as other metabolites. Interestingly, besides the formation of the reactive metabolite, tetrachloro-1,4-benzoquinone, other chlorinated phenols were also identified as metabolites of PCP (21). This was parallel with the identification of PCP as one of the metabolites of hexachlorobenzene (26).…”

Accumulation and Elimination of Pentachlorophenol in the Freshwater Bivalve Corbicula fluminea

“…We established using standards that at the retention time of PCP there were no interferences from 2,4,5-,2,4,6-and 3,4,5-trichlorophenols; 2,3,4,6-and 2,3,5,6-tetrachlorophenols; tetrachloro-p-hydroquinone and tetrachloro-p-benzoquinone which are metabolites excreted by mammals and some of them also by aquatic species (Renner and Hopfer 1990;Tjeerdema et al 1994). approximately after 72 hr.…”

“…The tubes were sealed and placed in a boiling water bath for 1 hr. This procedure is analogous to the one recommended by Renner and Hopfer (1990), and it was optimized in our laboratory for p-nitrophenol (Oneto et al , 1995). Once they were cool, the hydrolyzed solutions were treated with K2C03 until pH 10 was reached, and then acetylated by the procedure described previously.…”