No abstract

No abstract

1. The metabolism of pentachlorophenol in rats was studied. 2. Metabolites isolated from rat urine and identified were: 2,3,4,5-tetrachlorophenol, 2,3,4,6-tetrachlorophenol, 2,3,5,6-tetrachlorophenol, tetrachlorocatechol, tetrachlororesorcinol, trichlorohydroquinone, tetrachlorohydroquinone, and traces of trichloro-1,4-benzoquinone, and tetrachloro-1,4-benzoquinone.

The antibacterial activity of pentachlorophenol and 35 of its known or possible metabolites against 30 different species of bacteria was tested. In comparison with pentachlorophenol, no increase of inhibitory activity was found for any of the chlorinated anisoles tested (except for pentachloroanisole against Streptomyces spp.), 2-chlorophenol, 2,6-dichlorophenol, 2,3,6and 2,4,6-trichlorophenol, 2,3,5,6-tetrachlorophenol, tetrachloro-1,4and-1,3-benzenediol (except for the 1,3-isomer against Streptomyces spp.), tetrachloro-1,3dimethoxybenzene, and tetrachloro-1,3-benzenediol diacetate. Two chlorophenols, five dichlorophenols, four trichlorophenols, two tetrachlorophenols, and tetrachloro-1,2-benzenediol were more active than pentachlorophenol against some, but not all, of the strains tested.

The fungicidal activity of pentachlorophenol and its derivatives against 16 species of fungi representing 14 genera was tested. In relation to pentachlorophenol, no increase in fungistatic activity was found for pentachloroanisole, pentachloronitrobenzene, hexachlorobenzene, pentachlorophenyl acetate, o-and pchloranil, the three isomeric chlorophenols, 2,6-dichlorophenol, the three isomeric tetrachlorobenzenediols, the three isomeric tetrachlorodimethoxybenzenes, the three isomeric tetrachlorobenzenediol diacetates, and all of the isomeric mono-, di-, tri-, and tetrachloroanisoles, except for 2,3,5-trichloroanisole with Geotrichum candidadum PC 67 and for 2,3,5,6-tetrachloroanisole with Mucor circinelloides PC 1. Increasing fungistatic activities were seen with 3,5-dichlorophenol, four trichlorophenols, and 2,3,4,5-tetrachlorophenol for all of the strains, with four dichlorophenols, 2,4,6-trichlorophenol, and two tetrachlorophenols for some strains, and with 2,3,6-trichlorophenol for only one strain (M. circinelloides PC 1).