Metabolic studies with O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphorothioate (Dursban) insecticide in a lactating cow

Abstract

Dursban was absent from the milk and urine of a dairy cow fed 5 p.p.m. of the compound in the feed.A compound characterized by retention time as Dursban was found in the feces and represented 1.7%

Determination of Hydrolytic Metabolites of Organophosphorus Insecticides in Cow Urine Using an Improved Thermionic Detector

“…Thus, in a study of the fate of Dursban [ ,diethyl 0-(3,5,6-trichloro-2-pyridyl) phosphorothioate] insecticide fed to a cow at a very low feeding level (5 p.p.m. in the feed), the method was successfully used to determine the presumed hydrolysis products of Dursban (diethyl phosphate and diethyl thiophosphate) (Gutenmann et al, 1968).…”

An Assessment of the Health Risks of Seven Pesticides Used for Termite Control

“…When a lactating cow was fed chlorpyrifos in the diet at 5 ppm per day for 4 d, desethylated chlorpyrifos derivatives were not found (Gutenmann et al, 1968). Instead, diethylmethyl thiophosphate (35.9 percent of total dose) and diethylmethyl phosphate (26.8 percent) were recovered in the urine, and chlorpyrifos (1.7 percent) was found in the feces.…”

Residue determination of dichlorvos and related metabolites in animal tissue and fluids

“…Stanley (1966) demonstrated the utility of diazomethane for esterifying organic acids to effect derivatives easily resolved by gas chromatography. Gutenmann et al (1968) also described analyses of methyl esters in urine following acid treatment, ether extraction, and methylation. Using similar techniques, St. John and Lisk (1968a,b) determined hydrolytic metabolites of organophosphates using both methyl and ethyl esters for determining these compounds.…”