With economic development in China, the alcohol consumption increases sharply [1] and the prevalence of diabetes also increases greatly. Yang's study [2] showed that the age-standardized prevalence of total diabetes and prediabetes in China were 9.7% and 15.5%, respectively. The β-cell function of type 2 diabetic patients in Chinese-American is impaired earlier and more prominent performance [3]. Previous studies have shown alcohol intake was associated with insulin resistance (IR) and obesity [4][5][6][7], however, it is not clear the effect of alcohol consumption on β-cell secretion.The aim of this study was to evaluate whether alcohol consumption was associated with β-cell function, and the association may be further confounded by an Association of alcohol consumption with the impaired β-cell function independent of body mass index among Chinese men Abstract. Alcohol consumption is associated with type 2 diabetes. However, the relationship between alcohol consumption and β-cell function is still unclear. The aim of this study is to investigate the association between them. 675 Chinese men aged 20-75 years were recruited. The subjects were first classified into never drinkers, abstainers, light drinkers (0.1-19.9 g/day), moderate drinkers (20.0-39.9 g/day) and heavy drinkers (≥ 40.0 g/day) and then, were further divided into two subgroups according to body mass index (BMI) (BMI<25kg/m 2 and BMI ≥ 25kg/m 2 ). Analysis procedure was adjusted by the confounders including age, smoking status, BMI, waist circumference (WC), blood pressure, lipids and blood uric acid. Compared with never drinkers, alcohol consumption was associated with decreased homeostasis model assessment of β-cell function (HOMA-β) independent of BMI. The homeostasis model assessment of insulin resistance (HOMA-IR) was significantly correlated with alcohol consumption history in the group of BMI<25kg/m 2 and was significantly correlated with alcohol consumption in the group of BMI ≥ 25kg/m 2 . The results suggest that alcohol consumption is associated with the β-cell dysfunction independent of BMI in Chinese community dwelling men.Key words: Alcohol consumption, β-cell function, Body mass index, Chinese men increase in obesity among community-dwelling men in urban area of China.
methods
SubjectThe study sample was drawn from the central population register (≥5 years) aged 20-75 years living in Shungen, Shunya and Shunyu communities of Jinan City, China. We randomly recruited 1865 individuals attending face to face investigation. Study purpose and procedures were explained to participants. All subjects signed a written informed consent. The project was approved by the Ethics Committee of Provincial Hospital