Metabolic Syndrome and Depression

Heiskanen, Tuula H.; Niskanen, Leo; Hintikka, Jukka; Koivumaa‐Honkanen, Heli; Honkalampi, Kirsi; Haatainen, Kaisa; Viinamäki, Heimo

doi:10.4088/jcp.v67n0913

Cited by 133 publications

(88 citation statements)

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“…In fact, both depressive symptoms and somatized anxiety were more prevalent in infertile men with MetS. MetS is highly prevalent among patients with a history of depression, especially those with current major depression (Heiskanen et al, 2006), perhaps because of increased body fatness or lifestyle alterations. However, previous prospective data indicated that depression, hostility and anger predict increased risk of MetS (Goldbacher & Matthews, 2007).…”

Section: Discussionmentioning

confidence: 99%

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

et al. 2013

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SUMMARYMetabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and clinical characteristics in men with couple infertility. Out of 367 consecutive subjects, 351 men without genetic abnormalities were studied. MetS was defined according to the International Diabetes Federation&American Heart Association/National Heart,Lung, and Blood Institute classification. All men underwent physical, hormonal, seminal and scrotal ultrasound evaluation. Erectile and ejaculatory functions were assessed by International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD) and Premature Ejaculation Diagnostic Tool (PEDT), respectively, while psychological symptoms by Middlesex Hospital Questionnaire. Out of 351 patients, 27 (7.7%) fulfilled MetS criteria. Among ultrasound features, in an age-adjusted logistic model, only testis inhomogeneity was significantly associated with increasing MetS factors (HR = 1.36 [1.09-1.70]; p < 0.01). In an age-adjusted model, MetS was associated with a stepwise decline in total testosterone (TT) (B = À1.25 ± 0.33; p < 0.0001), without a concomitant rise in gonadotropins. At univariate analysis, progressive motility and normal morphology were negatively related to the number of MetS components (both p < 0.0001), but when age and TT were introduced in a multivariate model, only sperm morphology retained a significant association (B = À1.418 ± 0.42; p = 0.001). The risk of ED (IIEF-15-EFD score <26) increased as a function of the number of MetS factors, even after adjusting for age and TT (HR = 1.45[1.08-1.95]; p < 0.02). No association between PEDT score and MetS was observed. Finally, after adjusting for age and TT, somatization and depressive symptoms were associated with increasing MetS components (B = 0.66 ± 0.03, p < 0.05; B = 0.69 ± 0.03, p < 0.02; respectively). In conclusion, in men with couple infertility, MetS is associated with hypogonadism, poor sperm morphology, testis ultrasound inhomogeneity, ED, somatization and depression. Recognizing MetS could help patients to improve not only fertility but also sexual and overall health.

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Section: Discussionmentioning

confidence: 99%

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

et al. 2013

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“…The rate of the metabolic syndrome is especially high among persons with anxiety [121] and psychiatric disorders [122], including PTSD, as outlined in work by Pervanidou and Chrousos [68] as well as Rasmusson et al [65]. PTSD patients with comorbid depression appear to be at even greater risk for the metabolic syndrome [65,123].…”

Section: Metabolic Syndromementioning

confidence: 99%

Posttraumatic Stress Disorder and Cardiometabolic Disease

Levine¹,

Levine

Levine³

2013

Cardiology

133

118

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The need for addressing posttraumatic stress disorder (PTSD) among combat veterans returning from Afghanistan and Iraq is a growing public health concern. Current PTSD management addresses psychiatric parameters of this condition. However, PTSD is not simply a psychiatric disorder. Traumatic stress increases the risk for inflammation-related somatic diseases and early mortality. The metabolic syndrome reflects the increased health risk associated with combat stress and PTSD. Obesity, dyslipidemia, hypertension, diabetes mellitus, and cardiovascular disease are prevalent among PTSD patients. However, there has been little appreciation for the need to address these somatic PTSD comorbidities. Medical professionals treating this vulnerable population should screen patients for cardiometabolic risk factors and avail themselves of existing preventive diet, exercise, and pharmacologic modalities that will reduce such risk factors and improve overall long-term health outcomes and quality of life. There is the promise that cardiometabolic preventive therapy complementing psychiatric intervention may, in turn, help improve the posttraumatic stress system dysregulation and favorably impact psychiatric and neurologic function.

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“…It is characterized by elevated abdominal obesity, high triglycerides, high blood pressure, and high fasting blood glucose (FBG), and low HDL cholesterol and represents an important risk factor for CVD (5). Cross-sectional studies have shown an association between depression and the metabolic syndrome in young adults (6) and in middle-aged populations (7)(8)(9). Cross-sectional associations between depressive symptoms and individual components of the metabolic syndrome have been observed in a North American study of elderly male twins (10) but were not evident in a middle-aged cohort from northern Finland (11).…”

Section: Diabetes Care 32:499-504 2009mentioning

confidence: 99%

Association Between Metabolic Syndrome and Depressive Symptoms in Middle-Aged Adults

et al. 2009

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OBJECTIVE -Although it is possible that the association between depression and the metabolic syndrome is a "two-way street," the metabolic syndrome as a predictor of depression has been little investigated. We examined whether the metabolic syndrome is associated with the onset of depressive symptoms in a cohort of middle-aged British civil servants. RESEARCH DESIGN AND METHODS -Analyses included 5,232 participants(41-61 years of age) from the Whitehall II prospective cohort study. Depressive symptoms were assessed in 1991-1993 and again 6 years later using the depression subscale from the 30-item General Health Questionnaire. Metabolic syndrome was assessed in 1991-1993, according to National Cholesterol Education Program criteria.RESULTS -Presence of the metabolic syndrome was associated with an increased risk of future depressive symptoms, odds ratio 1.38 (95% CI 1.02-1.96) after adjustment for potential confounders. Of the five components, only central obesity, high triglyceride levels, and low HDL cholesterol levels predicted depressive symptoms. These components explained most of the association between the metabolic syndrome and the onset of depressive symptoms.CONCLUSIONS -Our results suggest that the metabolic syndrome, in particular the obesity and dyslipidemia components, is predictive of depressive symptoms. Diabetes Care 32:499-504, 2009

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Metabolic Syndrome and Depression

Cited by 133 publications

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Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Posttraumatic Stress Disorder and Cardiometabolic Disease

Association Between Metabolic Syndrome and Depressive Symptoms in Middle-Aged Adults

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