Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects

Mintoff, Dillon; Benhadou, Farida; Pace, Nikolai Paul; Frew, John W.

doi:10.1111/ijd.15910

Cited by 31 publications

(18 citation statements)

References 193 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, variants found by the RNA variant calling may be associated with several metabolic-related disorders, including metabolic syndrome (MetS). MetS concomitant with HS had already been described [ 105 , 106 , 107 ]. Nevertheless, it is not clear if inflammation induced by MetS leads to the initiation of HS or if the systemic inflammation in HS leads to manifestations of MetS [ 106 ].…”

Section: Discussionmentioning

confidence: 99%

“…MetS concomitant with HS had already been described [ 105 , 106 , 107 ]. Nevertheless, it is not clear if inflammation induced by MetS leads to the initiation of HS or if the systemic inflammation in HS leads to manifestations of MetS [ 106 ]. MetS is characterized by a combination of clinical conditions including central obesity, hyperglycemia, dyslipidemia, and/or hypertension [ 108 , 109 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

et al. 2022

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is an inflammatory skin condition clinically characterized by recurrent painful deep-seated nodules, abscesses, and sinus tracks in areas bearing apocrine glands, such as axillae, breasts, groins, and buttocks. Despite many recent advances, the pathophysiological landscape of HS still demands further clarification. To elucidate HS pathogenesis, we performed a meta-analysis, set analysis, and a variant calling on selected RNA-Sequencing (RNA-Seq) studies on HS skin. Our findings corroborate the HS triad composed of upregulated inflammation, altered epithelial differentiation, and dysregulated metabolism signaling. Upregulation of specific genes, such as KRT6, KRT16, serpin-family genes, and SPRR3 confirms the early involvement of hair follicles and the impairment of barrier function in HS lesioned skin. In addition, our results suggest that adipokines could be regarded as biomarkers of HS and metabolic-related disorders. Finally, the RNA-Seq variant calling identified several mutations in HS patients, suggesting potential new HS-related genes associated with the sporadic form of this disease. Overall, this study provides insights into the molecular pathways involved in HS and identifies potential HS-related biomarkers.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Although HS has well-documented associations with the metabolic syndrome, which is characterized by systemic inflammation identified at a molecular level [77], the role of adipose tissue in HS has barely been investigated. Obesity is currently shown to represent the primary risk factor in HS at the molecular level [4,28].…”

Section: Hs Pathogenesismentioning

confidence: 99%

Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis

Zouboulis

2021

Pharmaceutics

View full text Add to dashboard Cite

Chronic inflammation and dysregulated epithelial differentiation, especially of hair follicle keratinocytes, have been suggested as the major pathogenetic pathways of hidradenitis suppurativa/acne inversa (HS). On the other hand, obesity and metabolic syndrome have additionally been considered as an important risk factor. With adalimumab, a drug has already been approved and numerous other compounds are in advanced-stage clinical studies. A systematic review was conducted to detect and corroborate HS pathogenetic mechanisms at the molecular level and identify HS molecular markers. The obtained data were used to confirm studied and off-label administered drugs and to identify additional compounds for drug repurposing. A robust, strongly associated group of HS biomarkers was detected. The triad of HS pathogenesis, namely upregulated inflammation, altered epithelial differentiation and dysregulated metabolism/hormone signaling was confirmed, the molecular association of HS with certain comorbid disorders, such as inflammatory bowel disease, arthritis, type I diabetes mellitus and lipids/atherosclerosis/adipogenesis was verified and common biomarkers were identified. The molecular suitability of compounds in clinical studies was confirmed and 31 potential HS repurposing drugs, among them 10 drugs already launched for other disorders, were detected. This systematic review provides evidence for the importance of molecular studies to advance the knowledge regarding pathogenesis, future treatment and biomarker-supported clinical course follow-up in HS.

show abstract

“…Metabolic syndrome is present in 32.4% of HS patients [ 42 ]. A recent meta-analysis estimated the pool ratio of metabolic syndrome in HS to be 2.66 (95% CI: 1.90–3.72) [ 43 ]. There is also an association between HS and diabetes mellitus [ 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

Rached

Gambichler

Dietrich

et al. 2022

IJMS

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is a chronic inflammatory disease manifesting in inverse body regions. In a systematic review, the role of hormones in HS will be presented to better understand the pathomechanisms of HS. The review is based on the PRISMA criteria. Systematic research was carried out using keywords. Subsequently, the data were analyzed based on the clinical response and other relevant information. The main focus of our systematic review was on HS manifestation, exacerbation, sex hormones, antiandrogen therapy, thyroid function, polycystic ovary syndrome, insulin resistance, and adipokines. In HS, there appears to be a dysregulated adipokine release that is shifted towards pro-inflammatory adipokines. Insulin resistance is significantly more common in HS than in healthy patients regardless of BMI, age, and gender. Insulin resistance in HS patients leads to further cardiovascular disease. The mechanism of insulin resistance and role of adipokines should be investigated in future studies to better provide the pathomechanisms of HS. The role of androgens seems to be important in a certain subgroup of female patients. Anti-androgenic therapy can be useful and helpful in some patients. However, further studies are needed to better understand the hormonal relationship in HS.

show abstract

Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects

Cited by 31 publications

References 193 publications

Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis

The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

Contact Info

Product

Resources

About