Metabolic Syndrome and Risk of Lung Cancer: An Analysis of Korean National Health Insurance Corporation Database

Sin, Sooim; Lee, Chang Hoon; Choi, Sun Mi; Han, Kyung Do; Lee, Jun Young

doi:10.1210/clinem/dgaa596

Cited by 24 publications

(28 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increasing number of MS components positively correlated with a significant increase in cancer risk in adjusted models, except for non-Hodgkin lymphoma and prostate, lung and pre-menopausal breast cancer. The observed effect sizes for the cancers associated with MS in our data were broadly consistent with previous studies [7,9,[13][14][15][28][29][30][31][32][33][34]. Contrary to our study, Park et al reported a weaker association between MS and thyroid cancer [14], while Almquist and colleagues failed to report any association [35] using a z-score (standard score) calculation that included all 5 components of MS.…”

Section: Discussionsupporting

confidence: 91%

“…In accordance with previous studies, when stratifying by gender, the risk of colorectal, lung and bladder cancer was higher in men [7,9,15,30]. The positive association between MS and lung cancer was greater in smokers, corroborating the results reported in a recent cohort study [15].…”

Section: Plos Onesupporting

confidence: 92%

“…Some studies show that 1 or 2 components of MS are individually associated with colorectal, breast, endometrial, bladder, kidney, lung and thyroid cancer [9,[12][13][14][15]. Specifically, the effect of obesity and diabetes on the incidence of colorectal, pancreatic, liver, kidney, breast and endometrial cancer has already been described [16,17].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between metabolic syndrome and 13 types of cancer in Catalonia: A matched case-control study

et al. 2022

View full text Add to dashboard Cite

Background Metabolic syndrome (MS) is the simultaneous occurrence of a cluster of predefined cardiovascular risk factors. Although individual MS components are associated with increased risk of cancer, it is still unclear whether the association between MS and cancer differs from the association between individual MS components and cancer. The aim of this matched case-control study was to estimate the association of 13 types of cancer with (1) MS and (2) the diagnosis of 0, 1 or 2 individual MS components. Methods Cases included 183,248 patients ≥40 years from the SIDIAP database with incident cancer diagnosed between January 2008-December 2017. Each case was matched to four controls by inclusion date, sex and age. Adjusted conditional logistic regression models were used to evaluate the association between MS and cancer risk, comparing the effect of global MS versus having one or two individual components of MS. Results MS was associated with an increased risk of the following cancers: colorectal (OR: 1.28, 95%CI: 1.23–1.32), liver (OR: 1.93, 95%CI: 1.74–2.14), pancreas (OR: 1.79, 95%CI: 1.63–1.98), post-menopausal breast (OR: 1.10, 95%CI: 1.06–1.15), pre-menopausal endometrial (OR: 2.14, 95%CI: 1.74–2.65), post-menopausal endometrial (OR: 2.46, 95%CI: 2.20–2.74), bladder (OR: 1.41, 95%CI: 1.34–1.48), kidney (OR: 1.84, 95%CI: 1.69–2.00), non-Hodgkin lymphoma (OR: 1.23, 95%CI: 1.10–1.38), leukaemia (OR: 1.42, 95%CI: 1.31–1.54), lung (OR: 1.11, 95%CI: 1.05–1.16) and thyroid (OR: 1.71, 95%CI: 1.50–1.95). Except for prostate, pre-menopause breast cancer and Hodgkin and non-Hodgkin lymphoma, MS is associated with a higher risk of cancer than 1 or 2 individual MS components. Estimates were significantly higher in men than in women for colorectal and lung cancer, and in smokers than in non-smokers for lung cancer. Conclusion MS is associated with a higher risk of developing 11 types of common cancer, with a positive correlation between number of MS components and risk of cancer.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Plos Onesupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between metabolic syndrome and 13 types of cancer in Catalonia: A matched case-control study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Due to a lack of detailed data, we were also unable to correct our analysis for metabolic dysfunctions at baseline with the exception of diagnosis of type 2 diabetes. As metabolic dysfunctions are associated with central adiposity as well as lung cancer risk (59), the influence of early stage metabolic disturbances cannot be ruled out. Further, we did not have detailed measures on FFM specifically (eg.…”

Section: Discussionmentioning

confidence: 99%

The Obesity Paradox in Lung Cancer: Associations With Body Size Versus Body Shape

et al. 2020

View full text Add to dashboard Cite

“…A recent study on a large Chinese cohort demonstrated that higher fresh fruit intake significantly reduced the risk of diabetes [ 13 ]. Noteworthily, a most recent cohort study in a Chinese population demonstrated that the protective effect against T2D of a healthy lifestyle characterized by more daily fruit and less meat consumption was independent of genetic susceptibility of T2D [ 33 ]. However, the reciprocal effects among fruit, T2D, and its genetic predisposition were yet well elucidated [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Fruit intake, genetic risk and type 2 diabetes: a population-based gene–diet interaction analysis

Luo

Dai

et al. 2021

Eur J Nutr

View full text Add to dashboard Cite

Purpose Whether the association between fruit and type 2 diabetes (T2D) is modified by the genetic predisposition of T2D was yet elucidated. The current study is meant to examine the gene–dietary fruit intake interactions in the risk of T2D and related glycemic traits. Methods We performed a cross-sectional study in 11,657 participants aged ≥ 40 years from a community-based population in Shanghai, China. Fruit intake information was collected by a validated food frequency questionnaire by asking the frequency of consumption of typical food items over the previous 12 months. T2D-genetic risk score (GRS) was constructed by 34 well established T2D common variants in East Asians. The risk of T2D, fasting, 2 h-postprandial plasma glucose, and glycated hemoglobin A1c associated with T2D-GRS and each individual single nucleotide polymorphisms (SNPs) were tested. Results The risk of T2D associated with each 1-point of T2D-GRS was gradually decreased from the lower fruit intake level (< 1 times/week) [the odds ratio (OR) and 95% confidence interval (CI) was 1.10 (1.07–1.13)], to higher levels (1–3 and > 3 times/week) [the corresponding ORs and 95% CIs were 1.08 (1.05–1.10) and 1.07 (1.05–1.08); P for interaction = 0.04]. Analyses for associations with fasting, 2 h-postprandial plasma glucose and glycated hemoglobin A1c demonstrated consistent tendencies (all P for interaction ≤ 0.03). The inverse associations of fruit intake with risk of T2D and glucose traits were more prominent in the higher T2D-GRS tertile. Conclusions Fruit intakes interact with the genetic predisposition of T2D on the risk of diabetes and related glucose metabolic traits. Fruit intake alleviates the association between genetic predisposition of T2D and the risk of diabetes; the association of fruit intake with a lower risk of diabetes was more prominent in population with a stronger genetic predisposition of T2D.

show abstract

Metabolic Syndrome and Risk of Lung Cancer: An Analysis of Korean National Health Insurance Corporation Database

Cited by 24 publications

References 67 publications

Association between metabolic syndrome and 13 types of cancer in Catalonia: A matched case-control study

Association between metabolic syndrome and 13 types of cancer in Catalonia: A matched case-control study

The Obesity Paradox in Lung Cancer: Associations With Body Size Versus Body Shape

Fruit intake, genetic risk and type 2 diabetes: a population-based gene–diet interaction analysis

Contact Info

Product

Resources

About