Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients

Vachatova, Simona; Andrýs, Ctirad; Krejsek, Jan; Salavec, M; Řeháček, Vít; Čermáková, Eva; Málková, Andrea; Fiala, Zdeněk; Borská, Lenka

doi:10.1155/2016/5380792

Cited by 38 publications

(36 citation statements)

References 60 publications

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“…Patients with psoriasis have high levels of inflammatory markers, with C-reactive protein (CRP) (13), leptin (14) and TNF serum concentrations being significantly higher than in controls, whilst adiponectin levels are lower (14). While previous studies have separately shown an increased prevalence of CMDs (1), adipokine dysregulation (15) and increased visceral fat in psoriasis (16), to date no studies have assessed these relationships in a single cohort.…”

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confidence: 99%

Relationship of Visceral Fat and Adipokines with Cardiometabolic Diseases in Psoriasis

Mahyoodeen¹,

Crowther²,

Pillay³

et al. 2019

Acta Derm Venereol

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Abdominal obesity is common in patients with psoriasis. This study examined the relationship of abdominal fat, measured by computed tomography, in relation to metabolic diseases in a cohort of 103 patients with psoriasis and 98 control subjects. The results showed that increased visceral fat and related hormones were associated with an increased risk of psoriasis, type 2 diabetes and abnormal levels of lipids. Psoriasis was a risk factor for type 2 diabetes independent of abdominal fat. These findings show the importance of abdominal fat as a risk factor for psoriasis and metabolic diseases. As part of a larger cross-sectional, case-control study on cardiometabolic diseases in psoriasis this study investigated the association of visceral fat and serum adipokines with psoriasis and cardiometabolic diseases. A total of 103 patients with psoriasis and 98 controls, matched for body mass index, ethnicity and sex, were recruited over 15 months. Abdominal visceral fat was measured by computerized tomography. Logistic regression analysis revealed that visceral fat was associated with psoriasis (odds ratio (95% confidence interval): 1.56 (1.15, 2.11)), hyper triglyceridaemia (1.67 (1.22, 2.28)), low highdensity lipoprotein (1.63 (1.19, 2.22)) and type 2 diabetes (1.77 (1.24, 2.54)), (p < 0.005 for all). These respective associations were linked to serum interleukin6, adiponectin, tumour necrosis factor and insulin resistance. Psoriasis was associated with type 2 diabetes (7.94 (2.64, 23.9)), independent of visceral fat. These data suggest that visceral fat and its mediators play a key role in psoriasis-associated cardiometabolic diseases. Psoriasis itself is associated with an increased risk of type 2 diabetes.

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mentioning

confidence: 99%

Relationship of Visceral Fat and Adipokines with Cardiometabolic Diseases in Psoriasis

Mahyoodeen¹,

Crowther²,

Pillay³

et al. 2019

Acta Derm Venereol

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“…Recently, it has been recognized that fat cells exhibit remarkable intrinsic inflammatory properties. Adipocytes activate multiple inflammatory signaling cascades, inducing and secreting a large number of potent inflammatory cytokines such as interleukin (IL)‐6, IL‐1 and tumor necrosis factor (TNF)‐α . This weak but chronic production of pro‐inflammatory factors affect both the innate and the acquired immune system and may play a central role in the pathogenesis of psoriasis .…”

Section: Discussionmentioning

confidence: 99%

“…Adipocytes activate multiple inflammatory signaling cascades, inducing and secreting a large number of potent inflammatory cytokines such as interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)a. 5,8,9 This weak but chronic production of pro-inflammatory factors affect both the innate and the acquired immune system 10 and may play a central role in the pathogenesis of psoriasis. 11 In addition, changes in the levels of leptin, adiponectin and resistin secreted by adipocytes suggest that these factors also play an important role in the onset of psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Body mass index in psoriatic patients with or without familial psoriasis

Bayaraa

Arima

Imafuku

2020

The Journal of Dermatology

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Psoriasis is a chronic inflammatory disease caused by both genetic and environmental factors. The occurrence of psoriasis in family members indicates a genetic predisposition, while obesity is also a major contributor to psoriasis. We examined whether patients with versus without familial psoriasis were obese at the onset of psoriasis. Clinical information, including age at onset, age at first visit and body mass index (BMI) at first visit, was extracted from the Fukuoka University Psoriasis Registry. To compare BMI, patients aged 10 years or older who visited the clinic within 3 years of onset were selected. Familial psoriasis was observed in 27 patients (15 male, 12 female) out of 428 individuals (264 male, 164 female) with psoriasis, accounting for 6.3% of cases. Age at onset was younger for both men and women with familial psoriasis (34 ± 17 and 40 ± 15 years, respectively) relative to those with non‐familial psoriasis (48 ± 19 and 53 ± 19 years, respectively). We examined age‐ and sex‐adjusted average values of BMI at initial presentation after onset of psoriasis, finding that patients with familial psoriasis had lower BMI (22.0 kg/m2 [95% confidence interval, 21.8–22.4]) than those with non‐familial psoriasis (23.2 [23.1–23.3], P < 0.001). Individuals with a family history of psoriasis should be considered to be at risk for developing the disease even if obesity is not present.

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“…Recently, numerous studies have shown a positive association between metabolic syndrome and adult psoriasis . However, limited studies have been done on the association between metabolic syndrome and pediatric psoriasis.…”

Section: Introductionmentioning

confidence: 99%

“…1 Recently, numerous studies have shown a positive association between metabolic syndrome and adult psoriasis. [3][4][5][6][7][8] However, limited studies have been done on the association between metabolic syndrome and pediatric psoriasis. A metaanalysis of seven studies, which assessed the metabolic syndrome and cardiovascular risks of pediatric psoriasis, found that children with psoriasis had 6.10 times the risk of having metabolic syndrome than children without psoriasis (in only three studies).…”

Section: Introductionmentioning

confidence: 99%

Association of metabolic syndrome with pediatric psoriasis: a case‐control study in Kabul, Afghanistan

2020

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Background Limited studies have assessed the risk of metabolic syndrome in pediatric psoriasis. This study was aimed to investigate the association of obesity and metabolic syndrome with pediatric psoriasis in Afghanistan. Methods A case‐control study was conducted from March to December 2018 at the dermatology department of Maiwand Teaching Hospital in Kabul city. Participants were children aged less than 18 years; 113 children with psoriasis and 113 children without psoriasis were compared. Height, weight, waist circumference, and blood pressure were measured. Blood samples were taken following overnight fasting to test serum levels of glucose, triglyceride, cholesterol, and high‐density lipoprotein cholesterol. Analyses were done using Chi‐square test and independent t test. Odds ratio and 95% confidence interval were calculated. Results The mean age was 13.9 ± 3.7 and 13.4 ± 3.4 years in the psoriasis and control groups, respectively. Males comprised 54.9% of the psoriasis group and 41.6% of the control group. Family history of skin disorders was higher among children with psoriasis compared to the control group (23.0% vs. 13.7%; P < 0.001). Children with psoriasis were more likely to be overweight/obese (27.4% vs. 12.4%, OR = 2.67; P = 0.005), to have central adiposity with waist‐height ratio of 0.5 or greater (23% vs. 9.7%, OR = 2.77; P = 0.007), and to have metabolic syndrome (13.3% vs. 2.3%, OR = 5.23; P = 0.005). Conclusion The study revealed that children with psoriasis were more likely to have metabolic syndrome and cardiovascular risk factors compared to children without psoriasis.

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Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients

Cited by 38 publications

References 60 publications

Relationship of Visceral Fat and Adipokines with Cardiometabolic Diseases in Psoriasis

Relationship of Visceral Fat and Adipokines with Cardiometabolic Diseases in Psoriasis

Body mass index in psoriatic patients with or without familial psoriasis

Association of metabolic syndrome with pediatric psoriasis: a case‐control study in Kabul, Afghanistan

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