Metabolic syndrome and systemic inflammation in patients with chronic obstructive pulmonary disease

Hosny, Hossam; Abdel-Hafiz, H.; Moussa, Hanan; Soliman, Amin R.

doi:10.1016/j.ejcdt.2013.02.007

Cited by 12 publications

(15 citation statements)

References 31 publications

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“…COPD patients were significantly older, had a significantly lower BMI and were more often males (data not shown). As presented in Figure 2, a higher prevalence of MetS among COPD patients compared to controls was found in 9 out of 10 studies (23,25,30,34,(36)(37)(38)(39)41), and was significant in 5 studies (23,30,34,37,38). The overall mean prevalence of MetS in COPD patients was 32% (23-58%) versus 30% (17-54%) in controls (p = 0.001).…”

Section: Differences In Prevalence Of Mets and Its Components Betweenmentioning

confidence: 80%

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The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

Lipovec

Beijers

Borst

et al. 2016

COPD: Journal of Chronic Obstructive Pulmonary Disease

140

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Type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases (CVD) are common in patients with chronic obstructive pulmonary disease (COPD). Prevention of these co-morbidities in COPD requires knowledge on their risk factors. Metabolic syndrome (MetS) predisposes to the development of T2DM and CVD but its prevalence in COPD remains unclear. The aim of this review was to assess the prevalence of MetS and its components in COPD patients compared to controls and to investigate the contribution of clinical characteristics to MetS prevalence. We systematically searched PubMed and EMBASE for original studies in COPD that have investigated the prevalence of MetS and its components. In total, 19 studies involving 4208 COPD patients were included. The pooled MetS prevalence was 34%. Compared to controls, the prevalence was higher in COPD (10 studies, 32% and 30%, p = 0.001). The three most prevalent components in both COPD and controls were arterial hypertension (56% and 51%), abdominal obesity (39% and 38%) and hyperglycemia (44% and 47%). Compared to COPD patients without MetS, those with MetS had higher body mass index (BMI) (29.9 and 24.6 kg/m 2 , p < 0.001), higher forced expiratory volume in 1 second (FEV 1 ) % predicted (54 and 51, p < 0.001) and were more frequently female (31% and 25%, p = 0.011). In conclusion, the prevalence of MetS in COPD patients is high and hypertension, abdominal obesity and hyperglycemia are the most prevalent components. Further studies are needed to evaluate the impact of lifestyle factors and medications on MetS in COPD.

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Section: Differences In Prevalence Of Mets and Its Components Betweenmentioning

confidence: 80%

“…In total, 10 studies compared COPD patients (n = 2864) with a control group (n = 24532) (25,30,34,(36)(37)(38)(39)(40)(41). Characteristics of COPD patients are shown in Table 2, characteristics of the controls are presented in Supplemental Table S1.…”

Section: Differences In Prevalence Of Mets and Its Components Betweenmentioning

confidence: 99%

The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

Lipovec

Beijers

Borst

et al. 2016

COPD: Journal of Chronic Obstructive Pulmonary Disease

140

View full text Add to dashboard Cite

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“…This review discusses known and emerging mechanisms of disease pathogenesis, which could be shared across multimorbidity, using COPD, atherosclerosis and T2D as exemplar diseases. While these are among the most common noncommunicable chronic diseases globally, they also present as risk factors for each other and there is an increased prevalence of COPD, atherosclerosis or T2D in patients with a diagnosis of any of these conditions [16][17][18]. In particular, this review will focus on the shared role of the neutrophil in these diseases.…”

Section: Introductionmentioning

confidence: 99%

Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target

2020

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Multimorbidity is increasingly common and current healthcare strategies are not always aligned to treat this complex burden of disease. COPD, type-2 diabetes mellitus (T2D) and cardiovascular disease, especially atherosclerosis, occur more frequently together than expected, even when risk factors such as smoking, obesity, inactivity and poverty are considered. This supports the possibility of unifying mechanisms that contribute to the pathogenesis or progression of each condition.Neutrophilic inflammation is causally associated with COPD, and increasingly recognised in the pathogenesis of atherosclerosis and T2D, potentially forming an aetiological link between conditions. This link might reflect an overspill of inflammation from one affected organ into the systemic circulation, exposing all organs to an increased milieu of proinflammatory cytokines. Additionally, increasing evidence supports the involvement of other processes in chronic disease pathogenesis, such as cellular senescence or changes in cellular phenotypes.This review explores the current scientific evidence for inflammation, cellular ageing and cellular processes, such as reactive oxygen species production and phenotypic changes in the pathogenesis of COPD, T2D and atherosclerosis; highlighting common mechanisms shared across these diseases. We identify emerging therapeutic approaches that target these areas, but also where more work is still required to improve our understanding of the underlying cellular biology in a multimorbid disease setting.

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“…Our study results correlates with the study results of Hosney H et al in 2012 which showed no statically significant difference in TG level among cases and control group. 18 TC showed no significant difference between the cases and control groups. The results of our study doesn't correlate with study conducted by K Begum et al in 2010 which showed that TC concentration is statically significant in case group as compared with control group.…”

Section: Tgmentioning

confidence: 69%

“…In contrary, a study conducted by K Begum et al in 2010 showed that VLDL concentration in COPD patients was significantly higher than the controls (p = 0.001). 18 Serum lipid TG, VLDL levels showed no statically significant difference in moderate (Grade II), severe (Grade III), very severe (Grade IV) (COPD according to GOLD criteria). Correlation of mean total cholesterol levels of patients with moderate, severe, very severe COPD was statically significant between moderate to severe and very severe but not between severe and very severe for both LDL and Total cholesterol level.…”

Section: Tgmentioning

confidence: 86%

A study to assess nutritional profile in chronic obstructive pulmonary disease patients

et al. 2017

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Background: The potential ill effects of malnutrition are numerous, such as decreased maximal respiratory muscle force, decreased hypoxic Ventilatory response and decreased resistance to infection. The objective was to assess nutritional profile in chronic obstructive pulmonary disease (COPD) patient.Methods: The study was conducted at a tertiary care referral hospital. Period of study was one year. Present study was case control study. Institutional Ethics committee permission was taken. A total of 75 cases of chronic obstructive pulmonary disease and comparable controls were included in the study.Results: Present study shows that there was significant difference in mid arm circumference and mid-thigh circumference between COPD cases and control groups as well as between serum pre-albumin and serum transferrin level, serum uric acid (p=0.018) and serum calcium level (p=0.002). There was no statistically difference with respect to serum total protein (p=0.308), serum albumin (p=0.533) and serum phosphorus level (p=0.064) between COPD patient and control groups. There was statistically significant difference in total lymphocyte count between COPD cases and control groups as well as between serum LDL and serum HDL, serum LDL and serum HDL with COPD grading. As COPD grading increased there was significant decrease in serum LDL and serum HDL level. There was no significant difference with respect serum TG (p=0.738), VLDL and total cholesterol level (p=0.063) between COPD cases and control groups.Conclusions: Simple measurement of BMI, mid arm circumference and mid-thigh circumference can assess mal-nutrition in COPD patients and biochemical parameter like serum pre-albumin and serum transferrin may helpful in early detection of malnutrition.

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Metabolic syndrome and systemic inflammation in patients with chronic obstructive pulmonary disease

Cited by 12 publications

References 31 publications

The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target

A study to assess nutritional profile in chronic obstructive pulmonary disease patients

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