Metabolic syndrome and the progression of knee osteoarthritis on MRI

Jansen, Núria; Molendijk, Eveline; Schiphof, D.; Meurs, J.B. van; Oei, Edwin H.G.; Middelkoop, Marienke van; Bierma-Zeinstra, Sita M A

doi:10.1016/j.joca.2023.02.003

Cited by 19 publications

(7 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the relationship between diabetes prevalence and metabolic syndrome, it is hypothesized that the relationship between diabetes prevalence and KOA is stronger than HOA. Previous studies have indicated that metabolic disorders may contribute to the risk and progression of OA 42–44 . In a systematic review and meta‐analysis, 5 although OA increased the risk of T2D by 41%, T2D also increased the risk of OA by 46%, even after adjusting for BMI.…”

Section: Discussionmentioning

confidence: 94%

“…Previous studies have indicated that metabolic disorders may contribute to the risk and progression of OA. [42][43][44] In a systematic review and meta-analysis, 5 although OA increased the risk of T2D by 41%, T2D also increased the risk of OA by 46%, even after adjusting for BMI. This combines with our findings suggesting a bidirectional relationship between T2D and OA.…”

Section: Exposurementioning

confidence: 99%

See 1 more Smart Citation

Osteoarthritis and risk of type 2 diabetes: A two‐sample Mendelian randomization analysis

Xing

Pan

Cai

2023

Journal of Diabetes

View full text Add to dashboard Cite

BackgroundPhysical inactivity is an independent risk factor for type 2 diabetes (T2D). Osteoarthritis (OA) is a common joint disease that limits patients' physical activity, which may increase risk of other chronic diseases including T2D. However, studies evaluating the effect of OA on T2D are scarce. This study aimed to investigate the causal effect of knee and hip OA on risk of T2D from a genetic perspective.MethodsWe performed two‐sample Mendelian randomization (MR) analyses to obtain nonconfounding estimates of the effect of OA on T2D risk. Single nucleotide polymorphisms (SNPs) from genome‐wide association studies were selected as genetic instruments for radiographic knee and hip OA (ie, Kellgren–Lawrence grade ≥2). The associations of these SNPs with T2D were evaluated in participants from the UK Biobank. Sensitivity analyses were conducted to test the robustness of the MR results.ResultsGenetic predisposition of knee but not hip OA was significantly associated with an increased risk of T2D (knee OA: odds ratio [OR] 1.18, 95% confidence interval (CI) 1.09–1.27, p <.001; hip OA: OR 1.04, 95% CI 0.94–1.16, p = .425). Sensitivity analyses showed that the main findings are robust.ConclusionThe current study provides genetic evidence supporting that knee OA is a potential risk factor for T2D.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Exposurementioning

confidence: 99%

Osteoarthritis and risk of type 2 diabetes: A two‐sample Mendelian randomization analysis

Xing

Pan

Cai

2023

Journal of Diabetes

View full text Add to dashboard Cite

show abstract

“…Higher BMI levels correlate with higher pain scores, diminished physical activity and disability [ 3 ]. In a broader aspect, metabolic syndrome, a heterogeneous disorder characterized by central obesity, hypertension, dyslipidemia and impaired fasting glucose or diabetes has also been associated with knee OA [ 6 , 30 , 31 , 32 ]. As evidenced by results from the Chingford study, its components other than obesity (high blood glucose, hypertension and hypercholesterolemia) are independently associated with both unilateral and bilateral knee OA [ 30 ].…”

Section: Obesity Metabolic Syndrome and Knee Oamentioning

confidence: 99%

“…Obesity-related OA, also more broadly described as metabolic-syndrome-associated OA, is a complex condition that not only stems from the increased mechanical load on weight-bearing joints (such as the knee and hip) but the systemic effects of obesity-induced inflammation that further increase the risk of OA in other areas (such as the hand) [ 2 , 3 ]. Recently, advances in our understanding of the role of metabolic syndrome in the development and progression of knee OA highlighted the importance of further intervention studies that target different components of metabolic syndrome in order to investigate whether their modification could prevent the occurrence or progression of structural damage [ 6 ]. This review aimed to present the current concepts of knee osteoarthritis pathogenesis with particular focus on the role of obesity and other components of metabolic syndrome in disease initiation and progression.…”

Section: Introductionmentioning

confidence: 99%

Obesity-Related Knee Osteoarthritis—Current Concepts

Shumnalieva,

Kotov,

Monov

2023

Life

View full text Add to dashboard Cite

The knee is the joint most frequently involved in osteoarthritis and represents a significant contributor to patient morbidity and impaired functional status. Major risk factors include genetics, age, sex, mechanical load and obesity/metabolic syndrome. Recent studies highlighted the role of obesity and metabolic syndrome in the pathogenesis of knee osteoarthritis not simply through increased mechanical loading but the systemic effects of obesity-induced inflammation. The current concept of knee osteoarthritis is that of a ‘whole joint disease’, which highlights the involvement not only of articular cartilage but also the synovium, subchondral bone, ligaments and muscles. Obesity and metabolic syndrome are associated with higher levels of pro-inflammatory cytokines, increased production of adipokines with both protective and destructive effects on articular cartilage, an up-regulation of proteolytic enzymes such as matrix metalloproteinases and aggrecanases and an increase in free fatty acids and reactive oxygen species induced by dyslipidemia. These findings underscore that the adequate management of knee osteoarthritis needs to include an optimization of body weight and a beneficial mobility regimen. The possible introduction of pharmacological therapy targeting specific molecules involved in the pathogenesis of obesity-related osteoarthritis will likely also be considered in future therapeutic strategies, including personalized treatment approaches.

show abstract

“…The development of OA is related to a plethora of factors such as age, sex, genetics, trauma and increased mechanical load, as well as various concomitant diseases. In particular, obesity-related OA, also referred to as metabolic syndrome-associated OA, has recently been recognized as a separate entity [2,3,5]. It has been shown that obesity is related to knee OA not simply through an increased mechanical load on weight-bearing joints but through the maintenance of chronic inflammation, altered secretion of adipokines and development of sarcopenia [2,3].…”

Section: Introductionmentioning

confidence: 99%

Pathogenic Mechanisms and Therapeutic Approaches in Obesity-Related Knee Osteoarthritis

Shumnalieva,

Kotov,

Ermencheva

et al. 2023

Biomedicines

View full text Add to dashboard Cite

The knee is the joint most frequently involved in osteoarthritis, a common joint disorder in the adult population that is associated with significant chronic joint pain, reduced mobility and quality of life. Recent studies have established an association between obesity and the development of knee osteoarthritis that goes beyond the increased mechanical load on the knees as weight-bearing joints. This link is based on the maintenance of a chronic low-grade inflammation, altered secretion of adipokines by the adipose tissue and development of sarcopenia. Major adipokines involved in the pathogenesis of obesity-related knee osteoarthritis include adiponectin, which appears to have a protective effect, as well as leptin, resistin and visfatin, which are associated with higher pain scores and more severe structural damage. Joint pain in knee osteoarthritis may be both nociceptive and neuropathic and is the result of complex mechanisms driven by nerve growth factor, calcitonin gene-related peptide and pro-inflammatory cytokines. The role of endogenous cannabinoids and gut microbiota in common mechanisms between obesity and knee pain has recently been studied. The aim of the present review is to highlight major pathogenic mechanisms in obesity-related knee osteoarthritis with special attention on pain and to comment on possible therapeutic approaches.

show abstract

Metabolic syndrome and the progression of knee osteoarthritis on MRI

Cited by 19 publications

References 46 publications

Osteoarthritis and risk of type 2 diabetes: A two‐sample Mendelian randomization analysis

Osteoarthritis and risk of type 2 diabetes: A two‐sample Mendelian randomization analysis

Obesity-Related Knee Osteoarthritis—Current Concepts

Pathogenic Mechanisms and Therapeutic Approaches in Obesity-Related Knee Osteoarthritis

Contact Info

Product

Resources

About