Metabolic syndrome associated with toenail onychomycosis in Taiwanese with diabetes mellitus

Chang, Shun‐Jen; Hsu, Shih‐Chieh; Tien, Kai‐Jen; Hsiao, Jeng-Yueh; Lin, Shiu‐Ru; Chen, Hung‐Chun; Hsieh, Ming‐Chia

doi:10.1111/j.1365-4632.2008.03606.x

Cited by 41 publications

(33 citation statements)

References 32 publications

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“…The prevalence of onychomycosis among diabetics confirmed by culture was 77.2% (n=84).In earlier studies the prevalence ranged from of 17 to 30% [22][23][24]. In this study, age greater than 60 years was not significantly associated with presence of onychomycosis.…”

Section: Discussionmentioning

confidence: 43%

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Non-Dermatophyte as Pathogens of Onychomycosis among Elderly Diabetic Patients

Bridan¹

2017

JMEN

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Introduction: The purpose of this study was to determine the prevalence of causative non-dermatophyte as causative agents of onychomycosis in elderly diabetics from the Libya.Methods: The specimens were tested by direct microscopic examination using potassium hydroxide (20%) and culturing on Sabouraud's dextrose agar and fungobiotic agar containing cyclohexamide and chloramphenicol. Results:The most common cause of mycotic diabetic patients is different species of non-dermatophyte moulds isolated from 48 cases (41%). Yeasts were isolated from twenty six patients (22%). Dermatophytes were detected in only four patients (4%), and mixed fungi 6 (5%).There was no fungal growth in 28% of cases. Conclusion:The most common cause of mycotic diabetic patients is different species of non-dermatophyte moulds. This study confirmed that diabetic patients are at a high risk of having or contracting onychomycosis. Managing onychomycosis in diabetics may require systemic antifungal treatment, physical measures and patient education.

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Section: Discussionmentioning

confidence: 43%

“…In this study, age greater than 60 years was not significantly associated with presence of onychomycosis. Other studies have also reported a higher prevalence of onychomycosis among the elderly [13,20,23].…”

Section: Discussionmentioning

confidence: 93%

Non-Dermatophyte as Pathogens of Onychomycosis among Elderly Diabetic Patients

Bridan¹

2017

JMEN

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“…Chang SJ ve ark. 8 yaptığı araştırmada bizim çalışmamızda olduğu gibi fungal infeksiyonlu diyabetik hastalar ve fungal infeksiyon olmayan diyabetli hastalar karşılaştırılmış ve bizim araştırmamızla uyumlu olarak erkeklerde ve ileri yaşta anlamlı risk bulmuşlardır. Erkek cinsiyet ve ileri yaş onikomikoz gelişimi açısından en önemli risk faktörü gibi görünmektedir.…”

Section: Discussionunclassified

“…Hastaların VKİ'leri vücut ağırlığı (kg)/boy (m) 2 formülü ile hesaplandı. HbA1C değerleri 8 mmol/ mL ve üzerinde olan hastalar diyabeti regüle olmayan hastalar olarak kabul edildi 8 Dermatofit infeksiyonları olan ve olmayan hastalar karşılaştırıldığında diyabet süresi, erkek cinsiyet, yaş, nefropati, nöropati ve retinopati varlığı dermatofit infeksiyonu olanlarda anlamlı olarak fazla bulundu (hepsi için p<0,05). Dermatofit infeksiyonları için erkek cinsiyet, 50 yaş üzeri olmak, nefropati varlığı ve diyabet süresinin beş yıl ve üzerinde olması bağımsız risk faktörleri olarak saptandı (Tablo 5).…”

Section: Gereç Ve Yöntemunclassified

Tip 2 diyabetli hastalarda mukokutanöz fungal infeksiyonlar için risk faktörleri

Demirseren¹,

Akoğlu²,

Emre³

et al. 2014

TURKDERM

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Background and Design: Mucocutaneous fungal infections are common in patients with diabetes mellitus (DM). However, fungal infections do not develop in all patients with DM. In this study, we aimed to determine the risk factors for mucocutaneous fungal infections in patients with Type 2 DM. Materials and Methods: A total of 302 Type 2 DM patients with mucocutaneous fungal infections and 326 Type 2 DM patients without mucocutaneous fungal infections were enrolled. Demographic and clinical features, HbA1c levels, DM durations, body mass indexes (BMIs) and DM-related complications were compared between the groups and risk factors for developing mucocutaneous fungal infections were determined. Results: Of the 302 patients with mucocutaneous fungal infections, 81.2% (n=245) had dermatophytosis, 16.9% (n=51) had candida infections, and 2.0% (n=6) had pityriasis versicolor. Frequency of male gender, diabetic nephropathy, neuropathy and retinopathy; DM durations and age of patients were all significantly higher in diabetic patients with fungal infections than in patients without fungal infections (all p<0.05). Male gender, age ≥ 50 years, nephropathy and neuropathy were independently associated with fungal infection in Type 2 DM patients. In subgroup analyses, independent risk factors for dermatophytosis were male gender, age ≥ 50 years, DM duration ≥ 5 years, and nephropathy. For candidiasis, these factors were BMI≥30 and neuropathy. Conclusion: Elderly, male gender, diabetic neuropathy and nephropathy are closely associated with mucocutaneous infections in patients with Type 2 DM. (Turkderm 2014; 48: 87-91)

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“…Im Umkehrschluss wird die OM heute als unabhängiger und wichtiger Prädiktor eines diabetischen Fußsyndroms angesehen [6]. Eine weitere Studie hat gezeigt, dass Diabetiker mit OM ein 1,6-fach hö-heres Risiko für die Entwicklung eines diabetischen Fußulkus haben [4].…”

Section: Diabetes Mellitus Und Onychomykosenunclassified

Onychomykose – ein Update

Nenoff¹,

Ginter‐Hanselmayer

Hj³

2011

Hautarzt

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Onychomycosis describes a chronic fungal infection of the nails most frequently caused by dermatophytes, primarily Trichophyton rubrum. In addition, yeasts (e. g. Candida parapsilosis), more rarely molds (Scopulariopsis brevicaulis), play a role as causative agents of onychomycosis. However, in every case it has to be decided if these yeasts and molds are contaminants, or if they are growing secondarily on pathological altered nails. The point prevalence of onychomycosis in Germany is 12.4%, as demonstrated within the "Foot-Check-Study", which was a part of the European Achilles project. Although, onychomycosis is rarely diagnosed in children and teens, now an increase of fungal nail infections has been observed in childhood. More and more, diabetes mellitus becomes important as significant disposing factor both for tinea pedis and onychomycosis. By implication, the onychomycosis represents an independent and important predictor for development of diabetic foot syndrome and foot ulcer. When considering onychomycosis, a number of infectious and non-infectious nail changes must be excluded. While psoriasis of the nails does not represent a specific risk factor for onychomycosis, yeasts and molds are increasing isolated from patients with psoriatic nail involvement. In most cases this represents secondary growth of fungi on psoriatic nails. Recently, stigmatization and impairment of quality of life due to the onychomycosis has been proven.

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Metabolic syndrome associated with toenail onychomycosis in Taiwanese with diabetes mellitus

Abstract: Higher prevalence rates of onychomycosis were found in men and older DM patients. Metabolic syndrome, obesity, high TG levels, and poor glycemic control were associated with onychomycosis.

Cited by 41 publications

References 32 publications

Non-Dermatophyte as Pathogens of Onychomycosis among Elderly Diabetic Patients

Non-Dermatophyte as Pathogens of Onychomycosis among Elderly Diabetic Patients

Tip 2 diyabetli hastalarda mukokutanöz fungal infeksiyonlar için risk faktörleri

Onychomykose – ein Update

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