Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

Abstract

PROSPERO 2016 CRD42016048557.

Transgenerational Inheritance of Reproductive and Metabolic Phenotypes in PCOS Rats

“…This is consistent with previous reports that maternal testosterone exposure increases anxietylike behavior and impacts the limbic system in the offspring (38,39). Previous studies have shown a high incidence of familial aggregation of PCOS (11,12,30,35), which is more likely to occur in first-degree relatives (35). The same findings were confirmed by our experiment.…”

“…Due to its familial clustering and peripubertal onset, PCOS is characterized as an autosomal dominant genetic disease (9). Polycystic ovaries, testosterone levels, paternal metabolic syndrome (MBS) and type 2 diabetes mellitus (T2DM)-related defects in insulin secretion and action are all genetic factors for PCOS (4,(9)(10)(11).…”

“…On the other hand, due to the lack of a comprehensive understanding of the relationship between heredity and phenotype (10,11), parental androgen exposure is considered one of the most important factors in the early origin of PCOS (11,12). Animal models of PCOS have shown that early-life environment influences offspring characteristics in later life, including the metabolic syndrome (13).…”

Inter‐related effects of insulin resistance, hyperandrogenism, sympathetic dysfunction and chronic inflammation in PCOS

“…Polycystic ovary syndrome (PCOS) is a common and complex endocrine condition which affects 8 to 13 per cent of reproductive age women . Women with PCOS present with a range of features including reproductive, metabolic and psychological features .…”

Investigation of ADAMTS-1, BAX and IL-10 Expressions in Granulosa Cells Determinanting Fertilization Success in IVF

“…There is an important communication between granulosa cells and an oocyte in a developing follicle, and gene expression in maturing GCs is closely related to the production of competent oocytes (Cillo et al, 2007;Hamel et al, 2008;Jiang et al, 2010). GCs play a critical role in pathologic folliculogenesis not only in normal folliculogenesis but also in both benign disorders such as polycystic ovary syndrome (Yilmaz et al, 2018), early ovarian failure (POF), also called early ovarian failure. Some authors have found that granulosa cell apoptosis is the primary factor leading to follicular atresia and affects oocyte structure and oocyte development potential (Han et al, 2006;Elmore, 2007;Li et al, 2009).…”