Metabolic syndrome in antipsychotic naive African patients with severe mental illness in usual care

Abstract

There was a low prevalence and incidence of metabolic syndrome in this group of patients with a first episode of severe mental illness.

Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis

“…Overall, we identified 31 eligible studies for inclusion in this meta‐analysis (Tables S3 and S4) (Arranz et al, ; Basoglu et al, ; Cai et al, ; Canan et al, ; Chang et al, ; Chen et al, ; Chen et al, ; Dasgupta, Singh, Rout, Saha, & Mandal, ; Enez Darcin, Yalcin Cavus, Dilbaz, Kaya, & Dogan, ; Fernandez‐Egea et al, ; Garcia‐Rizo et al, ; Garcia‐Rizo et al, ; Grover, Nebhinani, Chakrabarti, Avasthi, & Kulhara, ; Kavzoglu & Hariri, ; Keinanen et al, ; Leo et al, ; Misiak et al, ; Nyboe, Vestergaard, Moeller, Lund, & Videbech, ; Petrikis et al, ; Ryan et al, ; Saddichha, Manjunatha, Ameen, & Akhtar, ; Saloojee, Burns, & Motala, ; Sengupta et al, ; Spelman et al, ; Turan, Kesebir, & Suner, ; van Nimwegen et al, ; Venkatasubramanian et al, ; Wani et al, ; Wu et al, ; Yildirim et al, ; Zhang et al, ). Of these studies, one was conducted with patients who had a first episode mania (Turan et al, ), five were conducted with patients who had first episode depression (Canan et al, ; Chang et al, ; Garcia‐Rizo et al, ; Grover et al, ; Leo et al, ) and one was conducted with patients who had first episode mania or depression (Garcia‐Rizo et al, ).…”

“…Of these studies, one was conducted with patients who had a first episode mania (Turan et al, ), five were conducted with patients who had first episode depression (Canan et al, ; Chang et al, ; Garcia‐Rizo et al, ; Grover et al, ; Leo et al, ) and one was conducted with patients who had first episode mania or depression (Garcia‐Rizo et al, ). Twenty‐four were conducted in patients with FEP (Arranz et al, ; Basoglu et al, ; Cai et al, ; Chen, Broqueres‐You, et al, ; Chen, Du, et al, ; Dasgupta et al, ; Enez Darcin et al, ; Fernandez‐Egea et al, ; Kavzoglu & Hariri, ; Keinanen et al, ; Misiak et al, ; Nyboe et al, ; Petrikis et al, ; Ryan et al, ; Saddichha et al, ; Saloojee et al, ; Sengupta et al, ; Spelman et al, ; van Nimwegen et al, ; Venkatasubramanian et al, ; Wani et al, ; Wu et al, ; Yildirim et al, ; Zhang et al, ). Among FEP studies, one study included patients with schizoaffective disorders (n = 4) in their patient group (n = 38) (Sengupta et al, ).…”

Metabolic syndrome in antipsychotic-naïve patients with first-episode psychosis: a systematic review and meta-analysis

“…After the removal of duplicates, 2473 abstracts and titles were screened. At the full-text stage, 112 were screened, 18 articles were included in a systematic review, 13 (De Hert et al, 2008;Effat et al, 2012;Enez Darcin, Yalcin Cavus, Dilbaz, Kaya, & Dogan, 2015;Garcia-Rizo et al, 2017;Grover, Nebhinani, Chakrabarti, Parakh, & Ghormode, 2012;Kraemer et al, 2011;Martín Otaño, Barbadillo Izquierdo, Galdeano Mondragón, Alonso Pinedo, & Querejeta Ayerdi, 2013;Medved, Kuzman, Jovanovic, Grubisin, & Kuzman, 2009;Owiredu, Osei, Amidu, Appiah-Poku, & Osei, 2012;Saddicha, Ameen, & Akhtar, 2007;Sahpolat & Ari, 2021;Saloojee, Burns, & Motala, 2018;Srivastava, Bhatia, & Sharma, 2018) articles were included in the main statistical analyses (prevalence of MetS in drug naïve, 0 days of antipsychotic medication) (Fig. 1) and an additional five studies that included up to 47 days were considered for the supplementary sensitivity analysis (see below).…”

“…We found that studies in Africa have the highest variability between their prevalence. Only two studies were performed in the Afro-descendant population, from Ghana and South Africa (Owiredu et al, 2012;Saloojee et al, 2018). We conducted sensitivity analysis removing those studies and we found changes in the overall prevalence from 13.2% to 16%.…”

“…Cohort comprised largely individuals of mixed ethnicity in the greater Cape Town areaa community where the prevalence of MetS and diabetes has hugely increased in recent years and is predicted to reach epidemic proportions. -Rizo et al, 2017;Grover et al, 2012;Kraemer et al, 2011;Martín Otaño et al, 2013;Medved et al, 2009;Saddicha et al, 2007;Sahpolat & Ari, 2021) and graded as medium (4-6 points) for four studies (Effat et al, 2012;Owiredu et al, 2012;Saloojee et al, 2018;Srivastava et al, 2018). Studies with a medium risk of bias (k = 4) reported a lower prevalence of 11% (95% CI 3.0-31.0) than studies with low risk of bias, which reported a prevalence of 13.9% (95% CI 8.0-21.0) but the difference between them is not statistically significant.…”