Metabolic Syndrome in Polish Ischemic Stroke Patients

Brola, Waldemar; Sobolewski, Piotr; Fudala, Małgorzata; Goral, A. Jedryka; Kasprzyk, Marta; Szczuchniak, Wiktor; Pejas-Dulewicz, Renata; Przybylski, Wojciech

doi:10.1016/j.jstrokecerebrovasdis.2015.06.003

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…In our study, the prevalence of MetS de ned by IDF criteria was 47.8% among patients with ischemic stroke, which was in line with the report from another study of stroke patients in China (51.3%) [21]. However, our prevalence was lower than that in Polish stroke patients (61.2%) based on the same criteria [22]. The difference might be due to the higher proportion of women in Polish study participants than ours (57.6% vs.…”

Section: Compared With Other Studiessupporting

confidence: 90%

Metabolic Syndrome in Patients With First-ever Ischemic Stroke: Prevalence and Association With Coronary Heart Disease

Liang¹,

Yan²,

Hao³

et al. 2021

Preprint

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Background: Most studies of metabolic syndrome (MetS) and coronary heart disease (CHD) have been carried out in the general population, and their association among stroke patients has been rarely explored. We seek to describe the prevalence of MetS among patients with acute ischemic stroke and to assess its association with CHD. Methods: This hospital-based study included 1851 patients with first-ever acute ischaemic stroke (mean age 61.2 years, 36.5% women) who were hospitalized into two university hospitals in Shandong, China (January 2016-February 2017). Data were collected through interviews, physical examinations, and laboratory tests. MetS was defined following the National Cholesterol Education Program (NCEP) criteria, the International Diabetes Federation (IDF) criteria, and the Chinese Diabetes Society (CDS) criteria. CHD was defined according to clinical and electrocardiogram examinations. Binary logistic regression was performed to determine the associations between MetS and CHD. Results: The overall prevalence of MetS was 34.0% by NECP criteria, 47.8% by IDF criteria, and 32.9% by CDS criteria. The prevalence of MetS decreased with age and was higher in women than men (p<0.05). Abdominal obesity, high blood pressure, high triglycerides, and low HDL-C were significantly associated with CHD (multi-adjusted OR range: 1.27-1.43, p<0.05). Compared with those without MetS, the multi-adjusted OR (95% CI) of CHD associated with MetS defined by the NECP criteria, IDF criteria, and CDS criteria was 1.29 (1.04-1.59), 1.46 (1.20-1.78), and 1.29 (1.05-1.59), respectively. In addition, having 1-2 abnormal components (vs. none) was associated with CHD (OR range: 1.63-1.73, p<0.05). Conclusions: MetS affects over one-third of patients with first-ever ischemic stroke. MetS is associated with an increased likelihood of CHD in stroke patients, but treating MetS as a binary entity would underestimate its association with CHD.

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Section: Compared With Other Studiessupporting

confidence: 90%

Metabolic Syndrome in Patients With First-ever Ischemic Stroke: Prevalence and Association With Coronary Heart Disease

Liang¹,

Yan²,

Hao³

et al. 2021

Preprint

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“…It is unclear why hyperglycemia was associated with END in women, but not in men. The possible reasons could include: (1) compared with men, women have a higher prevalence of impaired glucose tolerance and lower insulin sensitivity (47), and (2) metabolic syndrome (including hyperglycemia) is more frequent in women with AIS (48). This finding underscores the positive correlation between admission glucose levels and END in AIS women with blood glucose levels above 107.1 mg/dL at admission.…”

Section: Association Between Hyperglycemia End and Sexmentioning

confidence: 89%

Admission Glucose Levels May Increase the Risk for Early Neurological Deterioration in Females With Acute Ischemic Stroke

Huang

Zeng³

et al. 2020

Front. Neurol.

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Background and purpose: Early neurological deterioration (END) is associated with poor outcome for patients with acute ischemic stroke (AIS). Patients with hyperglycemia have increased risk for stroke and tend to have poor outcome with and without diabetes after stroke. The present study aimed to determine if blood glucose was associated with END and if sex difference was present in the development of END in AIS patients. Methods: A total of 220 consecutive patients (both males and females) with AIS between 2012 and 2015 were screened for this retrospective study. After exclusion, 213 patients were included for analysis. Propensity-score matching was used for normalization of variables including stroke severity, time from symptom onset to treatment, and treatment methods. Results: END was present in 68 patients (31.9%). Multivariate regression analysis showed that the risk of END was significantly higher in males with AIS than in females (P < 0.001), and admission blood glucose level was independently associated with END (P < 0.001). However, subgroup analysis demonstrated that admission glucose levels were significantly associated with increased risk for END only in females, but not in males (P = 0.008). When the cutoff value of 107.1 mg/dL was used, the admission blood glucose level had a significant predictive value for END prediction with a sensitivity of 100% and a specificity of 53% in female patients. Conclusions: The data demonstrated that sex difference was present for the development of END in AIS patients with an increased risk for males. The present study also showed that admission glucose level could be an important predicting factor for END in female patients with AIS.

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“…At the same time, in such cases there are about 60% of patients with metabolic syndrome, while there are about 20% of such patients among the other neurologic patients. Women, suffering from a metabolic syndrome, are especially subjected to ischemic strokes [ 19 , 20 ]. The same can be told about risk of coronary heart disease, especially in the senior age group which increases twofold in men and fivefold in women, suffering from metabolic syndrome [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Apheresis in Metabolic Syndrome

Voinov

2018

IEMAMC

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Background:The metabolic syndrome unites three pathologies of the person – obesity, arterial hypertension and diabetes. In recent years the progressing of such distribution covering from 2.5% to 3.8% of the population with increase twice each 10-15 years is noted. Even at maintenance of level of sugar at diabetes accumulation of the secondary metabolites breaking small vessels isn't excluded. At the same time many life-endangering complications develop.Objective:To identify the possibilities of plasmapheresis in the prevention and treatment of complications of metabolic syndrome.Method:Analysis of the world literature data on complications of metabolic syndrome and methods of their treatment.Results:At metabolic syndrome the frequency of strokes and myocardial infarctions there is twice more often than in population. For 5-9 years the general life expectancy decreases. Disorders of microcirculation at diabetes lead to a retinopathy with total loss of sight, a nephropathy from the outcome in a renal failure, to polyneuropathy and diabetic foot syndrome with high risk of high level amputations of the lower extremities. At the same time medicamentous therapy is not able to prevent such complications and almost only way of removal of these pathological metabolites is therapeutic apheresis, mainly the plasmapheresis. Data from our own studies confirm the effectiveness of such tactics.Conclusion:Plasmapheresis has to be applied not only to the correction of already critical conditions, but also to their prevention.

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Metabolic Syndrome in Polish Ischemic Stroke Patients

Cited by 12 publications

References 31 publications

Metabolic Syndrome in Patients With First-ever Ischemic Stroke: Prevalence and Association With Coronary Heart Disease

Metabolic Syndrome in Patients With First-ever Ischemic Stroke: Prevalence and Association With Coronary Heart Disease

Admission Glucose Levels May Increase the Risk for Early Neurological Deterioration in Females With Acute Ischemic Stroke

Therapeutic Apheresis in Metabolic Syndrome

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