Therapeutic Apheresis in Metabolic Syndrome

Voinov, V. A.

doi:10.2174/1871522218666180608114536

Cited by 6 publications

(6 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no significant difference in expression of visfatin in placental tissues between the two groups (P>0.05). It indicates that AGEs and IL-6 are highly expressed in placental tissues of GDM parturients, which is consistent with the studies of Voinov (30), and Wang et al (31). In this study, the expression of APN in placental tissues of GDM patients was low, indicating that there was abnormal regulation of adipokines in placenta.…”

Section: Discussionsupporting

confidence: 91%

“…The results of Dutta et al (40) showed that oxidative stress was associated with cell cycle arrest and fetal membrane oxidative injury, which jointly determined adverse pregnancy outcomes and were important factors for premature rupture of membranes and spontaneous premature birth. Studies on the relationship between AGE level and perinatal outcome in pregnant women with GDM have shown that high expression of AGEs is a risk factor for abnormal perinatal outcome in GDM (30). However, whether the AGEs, adipocytokines and oxidative stress levels can be used as important indicators to predict the pregnancy outcome with GDM requires further studies by expanding the number of samples.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus

Dong

2019

Exp Ther Med

View full text Add to dashboard Cite

Correlation between expression levels of advanced glycation end products (AGEs) and adipocytokines and oxidative stress index malondialdehyde (MDA) in placental tissues of pregnant women with gestational diabetes mellitus (GDM) was investigated. Seventy-two cases of GDM pregnant women who received routine prenatal examination and gave birth in the Department of Obstetrics, Binzhou City Center Hospital from March 2016 to May 2017 were collected as the observation group. Another 80 cases of normal pregnant women who gave birth at the same time were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the expression levels of AGEs, visfatin, APN and IL-6 in the lysate of placental tissues. MDA levels were measured by thiobarbituric acid method. Correlation of expression levels of AGEs, visfatin, APN, IL-6 and MDA were analyzed. The expression level of MDA in placental tissues of the observation group was significantly higher than that of the control group (t=16.44, P<0.001). The correlation of expression levels between AGEs, adipocytokines and MDA in placental tissues of the two groups was analyzed, and it was found that the expression levels of AGEs, visfatin and IL-6 in the two groups were positively correlated with MDA. There was a significantly negative correlation between APN and MDA in the two groups. The incidence of cesarean section, neonatal hypoglycemia, fetal distress and macrosomia in the observation group was significantly higher than that in the control group (P<0.05). There was no significant difference in the incidence of membrane rupture and premature birth between the two groups (P>0.05). In conclusion, the expression levels of AGEs, visfatin and IL-6 in placental tissues of GDM pregnant women are positively correlated with MDA. There is a significant negative correlation between APN and MDA, and they play an important role in the pathogenesis of GDM.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus

Dong

2019

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…The reason for the increased mortality with TPE in COVID-19 patients who have diabetes is not clear because plasma exchange has been shown to be beneficial not only in the treatment of SARS-CoV-2 but also in reducing complications of metabolic syndrome, particularly severe hypertriglyceridemia and the micro-vascular complications associated with type 2 diabetes. 16,17 In contrast to our study, Fernandez et al, demonstrated therapeutic plasma exchange as effective rescue therapy in 4 patients with multiple comorbidities, including type 2 diabetes mellitus, who had failed treatment with conventional treatment options such as antiviral agents. 18 A potential reason for the statistically insignificant results reported by our study is a small sample size, which can lead to more type II errors and low statistical power.…”

Section: Discussioncontrasting

confidence: 99%

The Efficacy of Plasma Exchange in Covid-19 Patients With Comorbid Diabetes Mellitus

Arshad

Zill

Khaliq

et al. 2021

PAFMJ

View full text Add to dashboard Cite

Objective: To explore the use of therapeutic plasma exchange as adjunctive therapy in COVID-19 patients with and without diabetes mellitus. Study Design: Prospective, observational study. Place and Duration of Study: Pakistan Emirates Military Hospital Rawalpindi, from Jan to Feb 2021. Methodology: A total of 90 male patients with laboratory-confirmed coronavirus infection were selected based on our inclusion criteria and their management and outcomes were recorded. The data were analyzed using SPSS-22 and Microsoft Excel. Results: The mortality rate was lower in patients who received 1 or more sessions of plasma exchange compared to those who did not receive plasma exchange (7.5% vs 12%). A lower mortality rate was seen in patients without diabetes who received therapeutic plasma exchange in addition to standard therapy compared to patients who received standard therapy alone (0 vs 14.82%, p=0.112). In patients with diabetes, a higher mortality rate was found in the group that had received therapeutic plasma exchange in addition to standard therapy instead of standard therapy alone (20% vs 8.7%, p=0.365). Conclusion: Overall our study supports the use of therapeutic plasma exchange in COVID-19 patients. However, although statistically insignificant, there appears to be a higher mortality rate in patients with diabetes who received therapeutic plasma exchange in addition to standard therapy. As such, we recommend further investigation of this aspect.

show abstract

“…It is necessary to detoxicate organism with removal pathological products resulting from virus reactivation to break through the course of the disease and to prevent complications. For this purpose, apheresis is the most effective therapy in removal pathological products and all components incompetent humoral immunity [20].…”

Section: Discussionmentioning

confidence: 99%

Nanomembrane-based Apheresis as Safe and Effective Therapy for Cytomegalovirus and Epstein-Barr Virus Reactivation

Slavic¹,

Djurdjic²,

Randjelović³

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Heavy training schedules or endurance competitions in marathon are forms of extreme physical stress and lead to immunodepression in runners which could be associated with increased susceptibility to viral reactivation by ubiquitous viral infection such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV). Lately, it was confirmed presence of elevated CMV and EBV loads and the lower antibody titers in competitive athletes. The most common clinical features are fatigue and adynamia accompanied with liver damage, varying from mild and transient elevation of aminotransferases to serious acute hepatitis and liver failure. CASE REPORT: Bearing in mind that a professional practice of marathon running is hazardous for the liver, therapeutic action is necessary as soon as possible to avoid serious complications and even cessation of professional competition. In our case report of professional female marathon runner, we need to treat CMV and EBV reactivation which caused liver damage, prevented regular trainings, and upcoming competitions. We opted for four sessions of nanomembrane based apheresis performed every other day for removal pathological products resulting from virus reactivation to break through the course of the disease and to prevent complications. After completing the whole procedure control laboratory tests and abdominal ultrasound were in physiological ranges. CONCLUSION: Hence, nanomembrane based apheresis can be effective and safe treatment of liver damages for elite marathon runners as well as for athletes.

show abstract

Therapeutic Apheresis in Metabolic Syndrome

Cited by 6 publications

References 106 publications

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus

The Efficacy of Plasma Exchange in Covid-19 Patients With Comorbid Diabetes Mellitus

Nanomembrane-based Apheresis as Safe and Effective Therapy for Cytomegalovirus and Epstein-Barr Virus Reactivation

Contact Info

Product

Resources

About