Metabolic Syndrome, Insulin Resistance, and Cognitive Dysfunction: Does Your Metabolic Profile Affect Your Brain?

Neergaard, Jesper Skov; Dragsbæk, Katrine; Christiansen, Claus; Nielsen, Henning Bay; Brix, Susanne; Karsdal, Morten A.; Henriksen, Kim

doi:10.2337/db16-1444

Cited by 81 publications

(58 citation statements)

References 50 publications

(43 reference statements)

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“…Metabolic syndrome and insulin resistance are associated with cognitive dysfunction and AD (53,(61)(62)(63)(64)(65). Therefore, because of our previous publication showing impaired glucosestimulated insulin secretion in TauKO and hTau mice (21), and our recent finding demonstrating insulin resistance in hTau animals, we initially hypothesized that the levels of insulin getting to the brain of these mouse models would be reduced.…”

Section: Discussionmentioning

confidence: 99%

Behavioral Abnormalities in Knockout and Humanized Tau Mice

et al. 2020

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Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervous system (CNS). Our group has previously shown that tau ablation triggers glucose intolerance and pancreatic dysfunction in mice, suggesting that tau plays a role in peripheral metabolic regulation. Little is known about the role of tau in anxiety. Moreover, inconsistent results have been generated regarding the effects of tau deletion in memory. Here, we characterize systemic insulin resistance, anxiety-related behavior and memory in 15 to 20 weeks old Wild-Type (WT), Tau knockout (TauKO) and a distinct hTau mouse model consisting of tau knockout expressing the longest isoform (2N4R) of a non-mutant WT human Tau protein under the prion promoter (hTau). Our findings demonstrate that tau deletion leads to anxiety-related behavior, impaired contextual and cued fear memory. The presence of a human Tau transgene did not ameliorate the phenotypes observed in animals lacking the mouse tau protein and it elicited impairments in learning, memory, and peripheral insulin sensitivity. Our results suggest that tau protein plays a role in memory and anxiety-related behavior. Our findings also indicate that previously unrecognized functions for tau protein may be a complicating factor in using animal models on the TauKO background. Understanding the link between tau pathophysiology and cognitive and metabolic alterations is of great importance to establish the complete contribution of tau protein to AD pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Behavioral Abnormalities in Knockout and Humanized Tau Mice

et al. 2020

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“…Since then, few prospective studies have explored the link between different markers of prediabetesimpaired glucose tolerance (IGT), FBG, or insulin resistance-and dementia, and the results of the studies that have been done are controversial. Findings from a 15-year follow-up study in Sweden showed that women with impaired FBG had higher odds of dementia than women with normal blood glucose (61). However, another Swedish community-based study that included >70-year-old men reported no association between FBG or impaired glucose tolerance and dementia over 12 years of follow-up (62).…”

Section: Prediabetes Diabetes and Dementiamentioning

confidence: 99%

Cognitive Trajectories of Older Adults With Prediabetes and Diabetes: A Population-Based Cohort Study

Marseglia

Aslan

Fratiglioni

et al. 2017

The Journals of Gerontology: Series A

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“…Although the effect of individual nutrients on health may be relatively easy to analyze, it is difficult to obtain accurate results because of the extinction or synergistic effects of nutrient interactions depending on the dietary patterns, even if the effects of single nutrients are analyzed [ 39 ]. Using an SQ-FFQ to analyze the frequency and trends of the overall dietary intake of subjects is believed to be an accurate way to determine the link between disease and diet [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that glucose regulation is associated with regulation of cognitive function. Poor glucose regulation may negatively affect speech and memory recall ability, which may cause chronic cognitive impairment [ 39 45 ]. Moreover, several studies have shown that glycemic control is associated with the regulation of cognitive function.…”

Section: Discussionmentioning

confidence: 99%

Association between diets and mild cognitive impairment in adults aged 50 years or older

Kim

Yun

2018

Nutr Res Pract

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BACKGROUND/OBJECTIVEAs aging progresses, the number of patients with cognitive impairment also increases. Cognitive function is not generally correlated with diet, and there is debate over that association. Thus, the present study aimed to investigate the association between dietary intake and cognitive function among adults aged 50 years or older.SUBJECTS/METHODSBetween July 2017 and March 2018, 324 adults aged over 50 years from Gwangju Sun-Han hospital participated in a dietary survey. The frequency of food intake and related information were collected using a semi-quantitative food frequency questionnaire (SQ-FFQ) and determining the mini-mental state examination (MMSE) level for 276 participants. The association between dietary intake and cognitive function was assessed by performing logistic regression analysis.RESULTSDepending on the MMSE score, the participants' age, education level, inhabitation status, medications, alcohol consumption, sleep duration, physical activity, and short geriatric depression scale score were significantly different (P < 0.05). Moreover, those participant characteristics were associated with either decreased or increased odds ratios (OR) for the risk of mild cognitive impairment (MCI). Based on analysis of the participants' intake of 112 detailed food items, which were categorized into 20 food types, intakes of cooked white rice (< 2 times/day compared with ≥ 3 times/day) (P < 0.05), properly cooked rice with other grains and legumes (P < 0.001), fruits (P < 0.05), milk (low fat and normal) (P = 0.044), liquid-type yogurt (P = 0.019), and curd-type yogurt (P = 0.015) were found to significantly decrease the OR for the risk of MCI.CONCLUSIONSAssociations were significant between the risk of MCI and the intake of certain food types. Specifically, a moderate intake of cooked white rice and an adequate intake of whole grains, fruits, milk, and dairy products were associated with reduced risks of MCI among adults aged over 50 years.

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Metabolic Syndrome, Insulin Resistance, and Cognitive Dysfunction: Does Your Metabolic Profile Affect Your Brain?

Cited by 81 publications

References 50 publications

Behavioral Abnormalities in Knockout and Humanized Tau Mice

Behavioral Abnormalities in Knockout and Humanized Tau Mice

Cognitive Trajectories of Older Adults With Prediabetes and Diabetes: A Population-Based Cohort Study

Association between diets and mild cognitive impairment in adults aged 50 years or older

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