Metabolic Syndrome Mortality in a Population-Based Cohort Study: Jichi Medical School (JMS) Cohort Study

The Association Between Reactive Oxygen Metabolites and Metabolic Syndrome in Asymptomatic Japanese Men

“…Previous studies indicated weak magnitudes of MetS on CVD in elderly populations [19,20], while another study reported a significant positive relationship between MetS and oxidative status in an elderly population [12]. Although the precise reasons for these findings remain to be unclear, our present study seems to support the former studies [19,20].…”

OMEGA Study: Design, Baseline Data, Metabolic Syndrome Prevalence in a Large-Scale Observational Study of Hypertensive Patients: The Olmesartan Mega Study to Determine the Relationship between Cardiovascular Endpoints and Blood Pressure Goal Achievement Study

“…The prevalence of the metabolic syndrome in other studies using the same criteria is shown in Table 3. Although a direct comparison to our data is limited because it is not adjusted for the difference in age distribution across the populations, the prevalence of the metabolic syndrome in men and women seems to be higher in the OMEGA study than in the general population (28)(29)(30) and similar to that in a diabetic population (31) and a hypertensive one (32). The Hisayama Study (14) showed that the risk of incident CVD increased with the number of components of the metabolic syndrome present.…”

Impact of Metabolic Syndrome Components on the Incidence of Cardiovascular Disease in a General Urban Japanese Population: The Suita Study

“…First, previous Japanese cohort studies associating MetS with CVD were based predominantly on BMI (3,4), non-fasting blood collection (3,4), and mortality as the endpoint (4,5). Our baseline subjects were observed in the fasting state, and we used waist circumference and a wide age range.…”

“…Previous papers have shown an association between MetS and cardiovascular disease (CVD) (2), but most studies conducted thus far have been based on Western populations. There have been several welldesigned prospective studies of Asian populations, and those studies had various limitations, including the use of body mass index (BMI) (3,4), non-fasting triglyceride and glucose levels (3,4), mortality (4,5), or small sample size (4)(5)(6)(7). In order to properly define MetS, it is essential to use data on waist circumference and on the levels of both fasting glucose and fasting triglycerides.…”