Metabolic Syndrome

Ravaglia, Giovanni; Forti, Paola; Maioli, Fabiola; Bastagli, L; Chiappelli, Martina; Montesi, Fausta; Bolondi, Luigi; Patterson, Christopher

doi:10.2337/dc06-0282

Cited by 84 publications

(61 citation statements)

References 23 publications

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“…Results from studies in elderly populations are more conflicting, with reports of no [16,22,25] and a slightly increased [17,23,26] risk of total mortality. Similarly, for CVD mortality, one study [16] found no increased risk, whereas others [17-21, 23, 25] have reported a slightly increased risk.…”

Section: Discussionmentioning

confidence: 85%

“…It is therefore a challenge that much of the data on the association between metabolic syndrome and mortality comes from samples consisting predominantly of younger and middle-aged individuals [2][3][4][8][9][10][11][12][13][14][15], while few studies have presented age-stratified analyses. Across the studies that have addressed this association in older cohorts, increased mortality risk has not been a consistent finding [16][17][18][19][20][21][22][23][24][25][26]. We therefore examined the relationship between metabolic syndrome and both subsequent cardiovascular and total mortality in individuals who were stratified into three groups by age (40-59, 60-74 and 75-89 years).…”

Section: Introductionmentioning

confidence: 99%

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Metabolic syndrome and risk of mortality in middle-aged versus elderly individuals: the Nord-Trøndelag Health Study (HUNT)

et al. 2009

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Aims/hypothesis Recent reviews indicate that the metabolic syndrome is a risk factor for cardiovascular disease and mortality, but evidence is scarce in elderly individuals. We therefore examined the relationship between the metabolic syndrome and mortality rates among individuals aged 40-59, 60-74 and 75-89 years. We also examined whether the syndrome was associated with mortality rates over and above the Framingham risk score. Methods We studied prospectively 6,748 men and women who participated in the Nord-Trøndelag Health Study, Norway, from 1995 to 1997 (HUNT 2) and defined the metabolic syndrome by the International Diabetes Federation criteria. Results During 53,617 person-years of follow-up (mean per person, 7.9 years), 955 individuals died, of whom 585 died from cardiovascular disease. Among individuals who were 40-59 years of age at baseline, the presence of the metabolic syndrome was associated with increased relative risk of cardiovascular and total mortality (age-and sexadjusted hazard ratios 3.97 [95% CI: 2.00-7.88] and 2.06 [1.35-3.13], respectively, equivalent to populationattributable risks of 20.7 and 14.2%, respectively). The Framingham risk score accounted for less than one-third of the effect of metabolic syndrome on mortality rates. After the age of 60 years, the metabolic syndrome was not associated with increased mortality rates. We found a significant interaction between the metabolic syndrome and age on the relative risk of mortality. Results were confirmed in a subsample without cardiovascular disease at baseline. Conclusions/interpretation The metabolic syndrome is a risk factor for mortality, over and above the Framingham risk score, in middle-aged, but not in elderly individuals.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and risk of mortality in middle-aged versus elderly individuals: the Nord-Trøndelag Health Study (HUNT)

et al. 2009

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“…Esta sín-drome tem impactos significativos a vários níveis, já que é notória a relação entre a SM e as doenças cardiovasculares implicadas com a morte precoce (15,21,30) . Além disso, a sua prevalência afecta diferentes estratos etários, sendo elevada tanto em adultos (36,43) , quanto em crianças e adolescentes (10,20,40,49,53) . Estes números reforçam a necessidade de tomar medidas urgentes direccionadas à prevenção e tratamento destas doenças assim como a redução dos seus factores de risco.…”

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“…Estudos que utilizaram os critérios recomendados pelo National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III), e adotados pela I Diretriz Brasileira de Diagnóstico e Tratamento da Síndrome Metabólica (I-DBSM) [6], encontraram valores de prevalência variando de 28,1% a 43,5% em idosos norte-americanos [11,12], de 11,3 a 34,3% entre idosos europeus [13][14][15][16] e de 24 a 30,5% em asiáticos [17,18]. Seguindo esses mesmos critérios, estudos com idosos brasileiros têm apresentado índices de prevalência de SM que variam de 45,2 a 51,6%, sendo essa prevalência significativamente maior entre as mulheres (45,6 a 73,5% versus 26,5 a 44,4% nos homens) [10,19,20].…”

Section: Introductionunclassified

Síndrome metabólica e estado nutricional de idosos cadastrados no HiperDia

Rosa

Agostini

Bianchi

et al. 2016

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. . A maioria dos participantes era do sexo feminino (62,5%), tinha síndrome metabólica (61,2%), e sobrepeso/ obesidade (59%). Ao analisar a associação do estado nutricional com síndrome metabólica e seus componentes, encontrou-se associação significativa de obesidade com síndrome metabólica, obesidade central, hipertrigliceridemia, e presença de quatro/cinco componentes da síndrome (p<0,001). O componente da síndrome metabólica mais frequente foi pressão arterial elevada (81,3%) e o menos frequente foi hipertrigliceridemia (48,2%). Em relação ao sexo, a frequência de síndrome metabólica foi significativamente maior entre as mulheres (p=0,004; 66,3% versus 52,7%). Conclusões: A frequência de síndrome metabólica e seus componentes e sua associação com o estado nutricional de idosos cadastrados no HiperDia fornece indícios de que síndrome metabólica e estado nutricional também devem ser monitorados através deste sistema. DESCRITORES: síndrome X metabólica; idosos; estado nutricional; índice de massa corporal; atenção primária à saúde. ABSTRACT Aims:To analyze the association of metabolic syndrome and its components with the nutritional status of elderly enrolled in the HiperDia system. Methods: This was a cross-sectional study with a sample of elderly enrolled in the HiperDia of Central Specialty Unit of Municipal Health Department from Cruz Alta, Rio Grande do Sul, whose records contained the information necessary for the study. Metabolic syndrome diagnosis was based on criteria established by the National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III) and recommended by the Brazilian Society of Cardiology in the I Brazilian Guidelines for Diagnosis and Treatment of Metabolic Syndrome. Nutritional status was assessed by body mass index, according to the classification of II Guidelines on Geriatric Cardiology of the Brazilian Society of Cardiology. In the statistical analysis, the Student t test and the chi-square test were used, with analysis of adjusted residuals. Results: At all 485 seniors met the inclusion criteria and were selected. The sample mean age was 68.9±6.8 years (range 60 to 94 years). Most participants were female (62.5%) had metabolic syndrome (61.2%), and overweight/obesity (59%). When analyzing the association between nutritional status and metabolic syndrome and its components, significant associations of obesity with metabolic syndrome, central obesity, hypertriglyceridemia, and presence of four/five components of the syndrome (p <0.001) were found. The most common metabolic syndrome component was high blood pressure (81.3%), and the less frequent was hypertriglyceridemia (48.2%). Regarding gender, the frequency of metabolic syndrome was significantly higher among women (p=0.004; 66.3% versus 52.7%). Conclusions:The frequency of metabolic syndr...

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Metabolic Syndrome

Cited by 84 publications

References 23 publications

Metabolic syndrome and risk of mortality in middle-aged versus elderly individuals: the Nord-Trøndelag Health Study (HUNT)

Metabolic syndrome and risk of mortality in middle-aged versus elderly individuals: the Nord-Trøndelag Health Study (HUNT)

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Síndrome metabólica e estado nutricional de idosos cadastrados no HiperDia

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