Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?

Piquereau, Jérôme; Boitard, Solène Emmanuelle; Ventura‐Clapier, Renée; Mericskay, Mathias

doi:10.3390/ijms23010030

Cited by 17 publications

(21 citation statements)

References 231 publications

(294 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, vitamin B plays an important role in energy metabolism [ 4 , 30 ], and its deficiency may impair energy metabolism and stimulate fat production, and lead to obesity. A study found that vitamin B also appears to improve metabolism [ 31 ]. Second, vitamin B has antioxidant and anti-inflammatory effects [ 32 , 33 , 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Association between Vitamin B and Obesity in Middle-Aged and Older Chinese Adults

Zhu

Huang

et al. 2023

Nutrients

View full text Add to dashboard Cite

Objective: Previous studies have found that obese people have lower levels of vitamin B, but most have focused on obesity as defined by body mass index (BMI), and its relationship with other types of obesity is unclear. The aim of this study was to explore the relationship between vitamin B levels and obesity assessed by different definitions among Chinese middle-aged and older community-dwelling adults. Methods: This cross-sectional study included 887 participants aged 45 years and older (45–82 years). The concentrations of vitamin B (B1, B2, B6, and B9) were measured by robotic dry blood spot extraction systems in combination with liquid chromatography–tandem mass spectrometry. BMI, body fat percentage (BF%), visceral fat area (VFA), and waist circumference (WC) were used to diagnose obesity. VFA and BF% were assessed by bioelectrical impedance analysis. The logistic regression model was used to assess the associations between vitamin B levels and the odds of obesity. Results: The average age of all participants was 60.77 (SD 6.33) years. The prevalence of obesity varied from 8.6% to 52.4% depending on different diagnostic criteria. After adjusting for covariates, a negative correlation was observed between vitamin B1 level and obesity according to the criteria of WC, VFA, and BF%, and the adjusted odds ratio (OR) was 0.47, 0.52, and 0.46, respectively. When using WC and BF% to define obesity, higher quartiles of vitamin B2 were negatively associated with the odds of obesity (OR: 0.62 and 0.62, respectively). Vitamin B6 was inversely associated with VFA-defined and BF%-defined obesity (OR: 0.64 and 0.64, respectively). When using VFA and BF% to define obesity, a negative correlation was observed in vitamin B9 (OR: 0.61 and 0.67, respectively). Conclusions: Vitamin B (B1, B2, B6, and B9) level was negatively related to obesity (defined by WC, VFA, or BF%) in Chinese middle-aged and older adults.

show abstract

Section: Resultsmentioning

confidence: 99%

Association between Vitamin B and Obesity in Middle-Aged and Older Chinese Adults

Zhu

Huang

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…In addition, our findings revealed that both vitamin B1 and B5 levels were elevated in the LV muscle tissue of TASK −/− mice. B vitamins are precursors of essential coenzymes that play an essential role in energy metabolism ( Piquereau et al, 2021 ). Despite vitamin B5 (pantothenic acid) being vital for CoA biosynthesis, and consequently for metabolism, research on B5 deficiency and supplementation in the context of heart disease is scarce ( Piquereau et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…B vitamins are precursors of essential coenzymes that play an essential role in energy metabolism ( Piquereau et al, 2021 ). Despite vitamin B5 (pantothenic acid) being vital for CoA biosynthesis, and consequently for metabolism, research on B5 deficiency and supplementation in the context of heart disease is scarce ( Piquereau et al, 2021 ). Several animal studies have reported that B5 has a cardioprotective effect due to its antioxidant properties ( Piquereau et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Low sodium intake ameliorates hypertension and left ventricular hypertrophy in mice with primary aldosteronism

Wang

Zhang²,

Bu³

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

The goal of this paper is to elucidate the effects of sodium restriction on hypertension and left ventricular (LV) hypertrophy in a mouse model with primary aldosteronism (PA). Mice with genetic deletion of TWIK-related acid-sensitive K (TASK)-1 and TASK-3 channels (TASK−/−) were used as the animal model of PA. Parameters of the LV were assessed using echocardiography and histomorphology analysis. Untargeted metabolomics analysis was conducted to reveal the mechanisms underlying the hypertrophic changes in the TASK−/− mice. The TASK−/− adult male mice exhibited the hallmarks of PA, including hypertension, hyperaldosteronism, hypernatremia, hypokalemia, and mild acid-base balance disorders. Two weeks of low sodium intake significantly reduced the 24-h average systolic and diastolic BP in TASK−/− but not TASK+/+ mice. In addition, TASK−/− mice showed increasing LV hypertrophy with age, and 2 weeks of the low-sodium diet significantly reversed the increased BP and LV wall thickness in adult TASK−/− mice. Furthermore, a low-sodium diet beginning at 4 weeks of age protected TASK−/− mice from LV hypertrophy at 8–12 weeks of age. Untargeted metabolomics demonstrated that the disturbances in heart metabolism in the TASK−/− mice (e.g., Glutathione metabolism; biosynthesis of unsaturated fatty acids; amino sugar and nucleotide sugar metabolism; pantothenate and CoA biosynthesis; D-glutamine and D-glutamate metabolism), some of which were reversed after sodium restriction, might be involved in the development of LV hypertrophy. In conclusion, adult male TASK−/− mice exhibit spontaneous hypertension and LV hypertrophy, which are ameliorated by a low-sodium intake.

show abstract

“…In turn, vitamins from the B complex (thiamine-vitamin B1; riboflavin-vitamin B2; niacinvitamin B3) are important cofactors in biochemical reactions, being essential for normal body growth and development, healthy skin, proper function of nerves and the heart, and red blood cell formation. Vitamins Bs are directly involved in energy metabolism and there is a recent interest in their role in the prevention of heart failure since there is a deficiency in vitamin B in patients affected by this clinical condition [53].…”

Section: Vitaminsmentioning

confidence: 99%

Unveiling the Bioactive Potential of Fresh Fruit and Vegetable Waste in Human Health from a Consumer Perspective

2022

View full text Add to dashboard Cite

Food supply disruption and shortage verified during the current pandemic events are a scenario that many anticipate for the near future. The impact of climate changes on food production, the continuous decrease in arable land, and the exponential growth of the human population are important drivers for this problem. In this context, adding value to food waste is an obvious strategy to mitigate food shortages, but there is a long way to go in this field. Globally, it is estimated that one-third of all food produced is lost. This is certainly due to many different factors, but the lack of awareness of the consumer about the nutritional value of certain foods parts, namely peels and seeds, is certainly among them. In this review, we will unveil the nutritional and bioactive value of the waste discarded from the most important fresh fruit and vegetables consumed worldwide as a strategy to decrease food waste. This will span the characterization of the bioactive composition of selected waste from fruits and vegetables, particularly their seeds and peels, and their possible uses, whether in our diet or recycled to other ends.

show abstract

Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?

Cited by 17 publications

References 231 publications

Association between Vitamin B and Obesity in Middle-Aged and Older Chinese Adults

Association between Vitamin B and Obesity in Middle-Aged and Older Chinese Adults

Low sodium intake ameliorates hypertension and left ventricular hypertrophy in mice with primary aldosteronism

Unveiling the Bioactive Potential of Fresh Fruit and Vegetable Waste in Human Health from a Consumer Perspective

Contact Info

Product

Resources

About