Metabolism of 1-Methyl-5-nitro-2-(2′ -pyrimidyl)imidazole

Preparation, structure and addition reactions of 4- and 5-aminoimidazoles

“…Chemical reductions of 4-and 5-nitroimidazoles 3 and 4 have been achieved using sodium amalgam43*44 stannous chloride44 or zinc dust in either 50% tetrafluoroboric acid46 or acetic acid. 50 The free bases 1 and 2 were not isolated and the products were obtained as salts or were converted into stable derivatives, e.g. amide or urea before isolation.…”

Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1H-imidazole, an antiprotozoal agent

“…11 Only in one case has an amino derivative been isolated. 12 The metabolites of metronidazole13 are essentially biologically inactive6,14 and metabolites of nimorazole15 have reduced activity when compared with the parent compound.6 Comparisons1 of the acute toxicities of 2-nitroimidazoles carrying alkyl side chains with those of the corresponding hydroxyalkyl derivatives confirmed the general rule that oxidation led to detoxification.…”