Metabolism of high density lipoprotein apolipoprotein A‐I and cholesteryl ester in insulin resistant dog: a stable isotope study

Briand, François; Bailhache, Edwige; Nguyen, Patrick; Krempf, Michel; Magot, T.; Ouguerram, Khadija

doi:10.1111/j.1463-1326.2006.00588.x

Cited by 4 publications

(2 citation statements)

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“…In the current study, greater APO-A1 concentrations were detected in dogs with ORMD as observed in proteomic analysis and verified by a specific assay. These results are consistent with those reported by Briand et al [ 24 ] who, in a stable isotope study, observed increased APO-A1 production in insulin resistant dogs.…”

Section: Discussionsupporting

confidence: 93%

Obese dogs with and without obesity-related metabolic dysfunction – a proteomic approach

et al. 2016

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BackgroundApproximately 20 % of obese dogs have metabolic disturbances similar to those observed in human metabolic syndrome, a condition known as obesity-related metabolic dysfunction. This condition is associated with insulin resistance and decreased circulating adiponectin concentrations, but clinical consequences have not been reported. In order to define better the metabolic changes associated with obesity-related metabolic dysfunction (ORMD), we compared the plasma proteomes of obese dogs with and without ORMD.A proteomic analysis was conducted on plasma samples from 8 obese male dogs, 4 with ORMD and 4 without ORMD. The samples were first treated for the depletion of high-abundance proteins and subsequently analysed by using 2-DE DIGE methodology.ResultsUsing mass spectrometry, 12 proteins were identified: albumin, apoliprotein A-I, C2, C3, C5, C4BPA, A2M, Uncharacterised protein (Fragment) OS = Canis familiaris, fibrinogen, IGJ, ITIH2, and glutathione peroxidase. In obese dogs with ORMD, the relative amounts of ten proteins (albumin, apoliprotein A-I, C2, C3, C5, C4BPA, A2M, Uncharacterised protein (Fragment) OS = Canis familiaris, fibrinogen, and ITIH2) were increased and two proteins (IGJ and glutathione peroxidase) were decreased, compared with obese dogs without ORMD. Specific assays were then used to confirm differences in serum albumin, apoliprotein A-I and glutathione peroxidase in a separate group of 20 overweight dogs, 8 with ORMD and 12 without ORMD.ConclusionsThe current study provides evidence that, in obese dogs with ORMD, there are changes in expression of proteins involved in lipid metabolism, immune response, and antioxidant status. The clinical significance of these changes remains to be defined.

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Section: Discussionsupporting

confidence: 93%

Obese dogs with and without obesity-related metabolic dysfunction – a proteomic approach

et al. 2016

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“…Insulin-resistant dogs have high triglyceride and nonesterified fatty acid (NEFA) levels, as well as low highdensity lipoprotein (HDL) cholesterol levels, which are the most common abnormalities in insulin-resistant humans [11]. The impact of insulin resistance was investigated on HDL metabolism in this animal model demonstrating a decrease in reverse cholesterol transport intensity [12]. Studies in insulin-resistant humans have shown that hypertriglyceridemia is related to a high very low-density lipoprotein (VLDL) production and delayed VLDL catabolism [13].…”

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The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes

et al. 2008

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Current literature in diabetes

2007

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Metabolism of high density lipoprotein apolipoprotein A‐I and cholesteryl ester in insulin resistant dog: a stable isotope study

Abstract: Lower HDL-CE selective uptake suggests that RCT is impaired in obese insulin resistant dog.

Cited by 4 publications

References 13 publications

Obese dogs with and without obesity-related metabolic dysfunction – a proteomic approach

Obese dogs with and without obesity-related metabolic dysfunction – a proteomic approach

The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes

Current literature in diabetes

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