The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes

Briand, François; Bailhache, Edwige; André, Agnès; Magot, T.; Krempf, Michel; Nguyen, Patrick; Ouguerram, Khadija

doi:10.1016/j.metabol.2008.02.013

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…Dogs and humans are known to have similar physiological metabolism and anatomical structures [20,21]. In dogs, exercise can cause changes in many physiological parameters.…”

Section: Introductionmentioning

confidence: 99%

Development of Novel Continuous and Interval Exercise Programs by Applying the FITT-VP Principle in Dogs

Lee

Kim

et al. 2020

The Scientific World Journal

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Although proper exercise training induces positive physiological effects, improper exercise can lead to injury, fatigue, and poor performance. The frequency, intensity, time/duration, type, volume, and progression (FITT-VP) are the essential components of exercise training to maintain or improve physical fitness and health. The purpose of this study was to develop specific exercise programs by applying the FITT-VP principle and to examine the effects on heart rate (HR) and hematological and biochemical parameters in dogs. The healthy male Beagles (n = 4) included in this study performed continuous and interval exercises, comprising 12 protocols. The HR monitoring elicited an affirmative response to activities but varied depending on the protocols. The hematologic parameters (e.g., red blood cell count, white blood cell count, hemoglobin, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration) were within the reference ranges both before and after exercise. The creatine kinase level significantly increased, and the cholesterol level decreased after exercises. In conclusion, the continuous and interval exercise program elicits an appropriate HR reaction, has no adverse effects on the serum parameters, and provides valuable insight for healthcare in dogs.

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“…Dogs and humans are known to have similar physiological metabolism and anatomical structures [20,21]. In dogs, exercise can cause changes in many physiological parameters.…”

Section: Introductionmentioning

confidence: 99%

Development of Novel Continuous and Interval Exercise Programs by Applying the FITT-VP Principle in Dogs

Lee

Kim

et al. 2020

The Scientific World Journal

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“…Kinetic parameters obtained in obese IR dogs before treatment are in the same range compared with that we have previously obtained in similar pathological conditions, taking into account large variability in this species (Briand et al, 2008). Given the animal size, the dog is well adapted to metabolic studies (i.e., kinetic studies and IR assessment).…”

Section: Discussionmentioning

confidence: 70%

Nicotinic Acid Decreases Apolipoprotein B100-Containing Lipoprotein Levels by Reducing Hepatic Very Low Density Lipoprotein Secretion through a Possible Diacylglycerol Acyltransferase 2 Inhibition in Obese Dogs

Bloch¹,

Leray²,

Chétiveaux³

et al. 2010

The Journal of Pharmacology and Experimental Therapeutics

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Apolipoprotein B100 (apoB100) is an essential component of very low density lipoprotein (VLDL) and low-density lipoprotein (LDL), both independent markers of cardiovascular risk. Nicotinic acid (NA) is an efficacious drug for decreasing VLDL and LDL, but the underlying mechanisms are unclear. For this purpose, six obese insulin-resistant dogs were given 350 mg/day of NA for 1 week and then 500 mg/day for 3 weeks. Turnover of apoB100-containing lipoproteins was investigated using stable isotope-labeled tracers. Multicompartmental modeling was used to derive kinetic parameters before and at the end of NA treatment. Hepatic diacylglycerol acyltransferase 2 (DGAT2), microsomal triglyceride transfer protein (MTP), hepatic lipase (HL), and adipose lipoprotein lipase (LPL) mRNA expression was also determined. NA treatment decreased plasma triglyceride (TG) (p Ͻ 0.001), VLDL-TG (p Ͻ 0.05), total cholesterol (p Ͻ 0.0001), and LDL cholesterol (p Ͻ 0.05), whereas plasma nonesterified fatty acids were unchanged. The decrease in VLDL-apoB100 concentration (p Ͻ 0.001) was the result of a lower absolute production rate (APR) (p Ͻ 0.001), despite a moderate decrease (p Ͻ 0.05) in fractional catabolic rate (FCR). LDLapoB100 concentration was reduced (p Ͻ 0.05), an effect related to a decrease in LDL APR (p Ͻ 0.05) and no change in FCR. NA treatment reduced DGAT2 expression (p Ͻ 0.05), whereas MTP, HL, and LPL expression was unchanged. Our results suggest that NA treatment reduced VLDL and LDL concentration as a consequence of a decrease in VLDL production.

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“…Only a very small increase in blood pressure has been documented as dogs gain weight, although the amount of change is affected by the type of fat in the diet (43,44) . Lipoprotein concentrations also change slightly in association with insulin resistance in dogs fed energy-dense diets (45,46) , but such changes may not have the same consequences as in human subjects because most of the lipoprotein in fasted dogs and cats is HDL and the prevalence of atherosclerosis and cardiac infarction in dogs and cats is very low (47) . Dogs derive twice as much energy from fat oxidation at rest and during exercise and starvation as human subjects (48,49) .…”

Section: Prevention Of Diseasementioning

confidence: 99%

Nutritional therapies to improve health: lessons from companion animals

Hill

2008

Proc. Nutr. Soc.

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Companion animals represent an under-utilised resource. The present paper is designed to encourage collaborative studies. Dogs and cats are out-bred animals that are willing to consume a consistent diet for long periods, so are ideal candidates for prospective studies of naturally-occurring disease. In some studies the effect of diet on survival has been substantial. Food restriction, for example, slows the development of osteoarthritis and increases the lifespan of Labrador retrievers by 2 years, protein and P restriction more than doubles the median survival time of dogs and cats with chronic kidney disease and adding n-3 fats and arginine to the diet of dogs with stage 3 lymphoma improves median survival time by one-quarter. Obesity is also very common in both dogs and cats and is also associated with disease as in human subjects. When interpreting these results, however, it is essential to take into account pathophysiological differences among species. Dogs and cats do not display all the characteristics of metabolic disease in human subjects, they metabolise fat well and atherosclerosis and cardiac infarction are uncommon. Such differences should not, however, preclude further study because differences among species often clarify knowledge. Monitoring of disease in companion animals may also provide a surveillance system for the safety of the food supply, as illustrated by recent outbreaks of acute renal failure and liver failure in cats and dogs in the USA caused respectively by melamine and mycotoxin contamination of pet foods.

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The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes

Cited by 6 publications

References 46 publications

Development of Novel Continuous and Interval Exercise Programs by Applying the FITT-VP Principle in Dogs

Development of Novel Continuous and Interval Exercise Programs by Applying the FITT-VP Principle in Dogs

Nicotinic Acid Decreases Apolipoprotein B100-Containing Lipoprotein Levels by Reducing Hepatic Very Low Density Lipoprotein Secretion through a Possible Diacylglycerol Acyltransferase 2 Inhibition in Obese Dogs

Nutritional therapies to improve health: lessons from companion animals

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