Metabolism of Natural Highly Unsaturated Fatty Acid, Tetracosahexaenoic Acid (24:6n-3), in C57BL/KsJ-<i>db</i>/<i>db</i> Mice

Abstract

INTRODUCTION Metabolic syndrome is associated with an increased risk of developing diabetes and cardiovascular disease. It is also associated with the accumulation of triglyceride TG in the liver and increased levels of cholesterol Ch and TG in the blood. Both genetic and dietary factors are known to play a role in the onset of the syndrome 1 3. For example, the Japanese have a much lower rate of cardiovascular disease compared to the Europeans and Americans 4. One of the reasons for this is thought to be the fact that fish has played a central role in the Japanese diet for a long time 5. Fish oil possesses attributes that can suppress the development of cardiovascular diseases and could play a role in the

Metabolomic and Microbial Remodeling by Shanmei Capsule Improves Hyperlipidemia in High Fat Food-Induced Mice

“…Naohiro Gotoh et al. showed that tetracosahexaenoic acid had the highest activity in inhibiting the accumulation of hepatic TG and reducing the increase in liver weight, and the order was higher than that of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid ( Gotoh et al., 2018 ). Punicic acid, a polyunsaturated fatty acid also known as omega-5 (ω-5), is a strong inhibitor of tumor necrosis factor-alpha (TNFα)-induced priming of reactive oxygen species production and myeloperoxidase release by neutrophils ( Tarek et al., 2009 ).…”

Tetracosahexaenoylethanolamide, a novel N-acylethanolamide, is elevated in ischemia and increases neuronal output

“…We therefore hypothesize that THEA can be implicated in neuromodulation during (or following) ischemic episodes in the brain. Furthermore, modes of increasing brain THA levels, possibly through diet (53), may be a means to further protect against ischemic episodes. With MSNs primarily being GABAergic in nature, future mechanistic studies might be designed to assess the effects of THEA on GABA receptors and GABAergic neurotransmission.…”

Effects of dietary supplementation of fish oil plus vitamin D3 on gut microbiota and fecal metabolites, and their correlation with nonalcoholic fatty liver disease risk factors: a randomized controlled trial

“…44,45 Besides, THA (C24:6, n-3) exerted beneficial effects in suppressing hepatic TG accumulation, reducing liver weight and increasing serum adiponectin levels in C57BL/KsJdb/db mice. 46 Although there has been no research to clarify the relationship between 8,9-DiHETrE and NAFLD, several studies have found that 8,9-DiHETrE levels were significantly higher in cardiovascular disease subjects. 47,48 In addition, one study supported a significant positive correlation relationship between plasma 8,9-DiHETrE and chronic metabolic-related disease events.…”