Metabolism of Phenothiazine Drugs

Effect of Certain Drugs on Perfused Human Placenta VI

“…aftrr administration, with only diphenhydramine and dibenarnine having a more prolonged onset. The range of duration of action, based upon the previously stated criterion, varied greatly, with chlorprumazine being by far the longest acting, as would be expected from the known localization of this compound in body tissues (20).…”

“…Serotonin has been implicated as a causative factor in the toxemias of pregnancy (14,15), certain forms of mental disease (l6), allergic disorders (17), and collagen diseases (18); in the toxemias of pregnancy the toxic effects of 20 serotonin are thought to be the rcsult of a constriction of the blood vessels of the placcnla with resulting ischemia (15).…”

Structurally stressed PT09SBA: A close look at the properties of large pore photoluminescent, redox active mesoporous hybrid silica

“…Aside from their long known use as neuroleptic and antihistaminic drugs, 1,2 phenothiazines (PTs) have been explored over the last years as photosensitizers and redox active chromophores for a variety of applications, including organic solar cells (DSCs), [3][4][5][6][7][8] self-assembled monolayer coatings, 9 and sensitizers for photopolymerizations. 10 PTs tend to form comparatively stable, long-lived radical cations, 11 and they have been widely covered in literature regarding their photochemistry 12 and their tunable spectral properties.…”

Dopaminergic D2 receptor binding of phenothiazine drugs and their metabolites

“…Phenothiazine drugs are metabolized to a number of different metabolites in the body, mainly by ring-sulphoxidation, ring-hydroxylation, N-demethylation, N-oxidation, sulphate-and glucuronide conjugation (Emmerson & Miya 1963, Usdin 1978. As discussed in a previous review (Dahl 1981), chlorpromazine, fluphenazine and perphenazine are extensively metabolized by ringsulphoxidation and aromatic ring-hydroxylation.…”