2019
DOI: 10.3233/nha-180043
|View full text |Cite
|
Sign up to set email alerts
|

Metabolism of sleep and aging: Bridging the gap using metabolomics

Abstract: Sleep is a conserved behavior across the evolutionary timescale. Almost all known animal species demonstrate sleep or sleep like states. Despite extensive study, the mechanistic aspects of sleep need are not very well characterized. Sleep appears to be needed to generate resources that are utilized during the active stage/wakefulness as well as clearance of waste products that accumulate during wakefulness. From a metabolic perspective, this means sleep is crucial for anabolic activities. Decrease in anabolism… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
6
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 9 publications
(6 citation statements)
references
References 137 publications
(196 reference statements)
0
6
0
Order By: Relevance
“…47 On the other hand, close to 98% of the body's serotonin exists peripherally, where it operates as a peripheral hormone, affecting vasoconstriction, intestinal motility, primary hemostasis, liver repair, and the control of the T-cell-mediated immune system. 48,49 The main neurotransmitters of hedonic and homeostatic systems are dopamine and serotonin, but other neurotransmitters are also involved. 50 There are two hypothesis that can explain caloric consumption: first, the reward deficiency hypothesis implying that people increase the food intake due to a decrease in the dopaminergic activity and second, the homeostatic hypothesis that implies a higher consumption of food due to disturbed homeostatic balance through a decreased level of serotonin in the hypothalamus.…”
Section: Dovepressmentioning
confidence: 99%
“…47 On the other hand, close to 98% of the body's serotonin exists peripherally, where it operates as a peripheral hormone, affecting vasoconstriction, intestinal motility, primary hemostasis, liver repair, and the control of the T-cell-mediated immune system. 48,49 The main neurotransmitters of hedonic and homeostatic systems are dopamine and serotonin, but other neurotransmitters are also involved. 50 There are two hypothesis that can explain caloric consumption: first, the reward deficiency hypothesis implying that people increase the food intake due to a decrease in the dopaminergic activity and second, the homeostatic hypothesis that implies a higher consumption of food due to disturbed homeostatic balance through a decreased level of serotonin in the hypothalamus.…”
Section: Dovepressmentioning
confidence: 99%
“…Furthermore, differences in urine metabolome were observed, including changes in acylcarnitines, glycerophospholipids and sphingomyelins [ 58 ]. Further metabolites that have been suggested as OSA-biomarkers are acylcarnitine C14:1, sphingomyelin 18:1 and symmetric dimethylarginine [ 1 ]. Urine metabolomics analysis was also applied to differentiate between OSA, simple snorers and healthy controls [ 43 ].…”
Section: Obstructive Sleep Apneamentioning
confidence: 99%
“…Sleep is a pivotal operating state of the central nervous system, which controls organismal well-being and might be the most well-preserved activity throughout the evolutionary timescale [ 1 , 2 ]. Sleep occupies up to a third of the human lifespan [ 3 ] and represents one of the most important psychophysiological processes for brain function and mental health [ 2 ].…”
Section: Introductionmentioning
confidence: 99%
“…Other classes of metabolites have been demonstrated to be affected by OSA. For example, acylcarnitines, glycerophospholipids, and sphingomyelin were found to be increased in the urine of moderate and severe OSA patients when compared to controls [ 28 ]. In an earlier study, Ferrarini et al utilized metabolomics to quantify various phospholipids in people diagnosed with severe and non-severe OSA [ 29 ].…”
Section: Introductionmentioning
confidence: 99%