Metabolism of strawberry mono- and dimeric ellagitannins in rats fed a diet containing fructo-oligosaccharides

Jurgoński, Adam; Juśkiewicz, Jerzy; Fotschki, Bartosz; Kołodziejczyk, Krzysztof; Milala, Joanna; Kosmala, Monika; Grzelak-Błaszczyk, Katarzyna; Markiewicz, Lidia Hanna

doi:10.1007/s00394-015-1133-5

Cited by 32 publications

(41 citation statements)

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“…In the present study, the dietary inclusion of different fruit pomaces was accompanied by health-promoting changes in blood plasma vitamin C (in BP treatment), catalase (groups AP and BP) and FRAP (groups AP and SSP) values, pointing to the involvement of different mechanisms. Those effects could be attributed, at least partially, to polyphenolic metabolites that can reach internal tissues, as demonstrated in previous studies conducted on laboratory rodents [50, 51]. The results of experiments with rodents, summarized by Manach et al [52], revealed that polyphenols and their metabolites may be detected in a wide range of tissues, including the brain, heart, bones and skin.…”

Section: Discussionmentioning

confidence: 64%

The Fatty Acid Profile and Oxidative Stability of Meat from Turkeys Fed Diets Enriched with n-3 Polyunsaturated Fatty Acids and Dried Fruit Pomaces as a Source of Polyphenols

et al. 2017

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The aim of this study was to determine the efficacy of different dietary fruit pomaces in reducing lipid oxidation in the meat of turkeys fed diets with a high content of n-3 polyunsaturated fatty acids (PUFAs). Over a period of 4 weeks before slaughter, turkeys were fed diets with the addition of 5% dried apple, blackcurrant, strawberry and seedless strawberry pomaces (groups AP, BP, SP and SSP, respectively) and 2.5% linseed oil. Pomaces differed in the content (from 5.5 in AP to 43.1 mg/g in SSP) and composition of polyphenols Proanthocyanidins were the main polyphenolic fraction in all pomaces, AP contained flavone glycosides and dihydrochalcones, BP contained anthocyanins, and SP and SSP—ellagitannins. The n-6/n-3 PUFA ratio in all diets was comparable and lower than 2:1. In comparison with groups C and AP, the percentage of n-3 PUFAs in the total fatty acid pool of white meat from the breast muscles of turkeys in groups BP, SP and SSP was significantly higher, proportionally to the higher content of α-linolenic acid in berry pomaces. The fatty acid profile of dark meat from thigh muscles, including the n-6/n-3 PUFA ratio, was similar and lower than 3:1 in all groups. Vitamin A levels in raw breast muscles were higher in group AP than in groups C and BP (P<0.05). The addition of fruit pomaces to turkey diets lowered vitamin E concentrations (P = 0.001) in raw breast muscles relative to group C. Diets supplemented with fruit pomaces significantly lowered the concentration of thiobarbituric acid reactive substances (TBARS) in raw, frozen and cooked meat. Our results indicate that the dietary application of dried fruit pomaces increases the oxidative stability of meat from turkeys fed linseed oil, and strawberry pomace exerted the most desirable effects due to its highest polyphenol content and antioxidant potential.

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Section: Discussionmentioning

confidence: 64%

The Fatty Acid Profile and Oxidative Stability of Meat from Turkeys Fed Diets Enriched with n-3 Polyunsaturated Fatty Acids and Dried Fruit Pomaces as a Source of Polyphenols

et al. 2017

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“…The observed changes in activity of the bacterial enzymes might be associated with the type and amount of polyphenols, as well as dietary fat in the diet. The raspberry pomaces used in this study were a rich source of ETs and ACs, which have antibacterial properties against certain groups of intestinal bacteria such as Clostridium leptum, Campylobacter spp., and E. coli CM 871 [10,11,43,44]. A previous study of rats fed a diet supplemented with raspberry polyphenol extracts obtained from pomace, showed that the intensity of the cecal microbiota activity might be related to the dosages and profiles of dietary polyphenols, e.g., the ET to FL ratio [45].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…Details concerning the sample preparation have been previously described [10]. The metabolites were determined using HPLC (Knauer Smartline system with a photodiode array detector, Berlin, Germany)…”

Section: Quantification Of Ellagitannin Metabolitesmentioning

confidence: 99%

“…The short-chain fatty acid (SCFA) concentrations were measured using gas chromatography (Shimadzu GC-2010, Kyoto, Japan) and a capillary column (SGE BP21, 30 m × 0.53 mm; SGE Europe Ltd., Milton Keynes, UK) as previously described [10]. The activities of selected bacterial enzymes ( -galactosidase, -glucosidase, -galactosidase and -glucosidase) released into the cecal environment were measured according to the rates of pand o-nitrophenol release from their nitrophenyl glucosides according to a previously described method [31].…”

Section: Sample Collection and Analysismentioning

confidence: 99%

“…Nevertheless, the modulation of the bacterial activity by the dietary addition of biologically active compounds, e.g., polyphenols and polyunsaturated fatty acids [9][10][11] might regulate the profile and concentration of the BA in the gastrointestinal tract. There is still little information regarding compounds that are able to regulate the BA profile in the gastrointestinal tract or their synthesis in the liver.…”

Section: Introductionmentioning

confidence: 99%

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Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet

Fotschki

Juśkiewicz

Jurgoński

et al. 2017

The Journal of Nutritional Biochemistry

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ReuseUnless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. ÔØ Å ÒÙ×Ö ÔØRaspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT ABSTRACTThe profile of bile acids (BA) largely depends on the enzymatic activity of the microbiota, but this can be modulated by the dietary addition of biologically active compounds, e.g., polyphenols and polyunsaturated fatty acids. The aim of this study was to examine the effect of dietary raspberry pomace as a rich source of biologically active compounds on microbial activity and the BA profile in the caecum of rats fed a high-fat diet.Wistar rats were fed the standard diet AIN-93, a high-fat diet or a modified high-fat diet enriched with 7% different types of processed raspberry pomaces produced by standard grinding and fine grinding, with or without seeds. Rats fed the high-fat diet for eight weeks showed some disorders in liver function and cecal BA, as manifested by an increased concentration of cholesterol, total BA in the liver and cholic, deoxycholic, and -muricholic acids in the cecal digesta. In general, irrespective of the type of raspberry pomace, these dietary preparations decreased liver cholesterol, hepatic fibroblast growth factor receptor 4, peroxisome proliferator-activated receptor alpha, cecal ammonia and favorable changed BA profile in the cecum. However, among all dietary pomaces, the finely ground preparation containing seeds had the greatest beneficial effect on the caecum by modulating bacterial activity and reducing the levels of secondary BA.

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Ellagitannins and Their Gut Microbiota‐Derived Metabolites: Urolithins

Garcı́a-Villalba

Giménez‐Bastida

Ávila‐Gálvez

et al. 2020

Dietary Polyphenols

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Metabolism of strawberry mono- and dimeric ellagitannins in rats fed a diet containing fructo-oligosaccharides

Cited by 32 publications

References 41 publications

The Fatty Acid Profile and Oxidative Stability of Meat from Turkeys Fed Diets Enriched with n-3 Polyunsaturated Fatty Acids and Dried Fruit Pomaces as a Source of Polyphenols

The Fatty Acid Profile and Oxidative Stability of Meat from Turkeys Fed Diets Enriched with n-3 Polyunsaturated Fatty Acids and Dried Fruit Pomaces as a Source of Polyphenols

Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet

Ellagitannins and Their Gut Microbiota‐Derived Metabolites: Urolithins

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