Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference

Niu, Youguo; Evans, Rhys

doi:10.1152/ajpendo.90260.2008

Cited by 11 publications

(19 citation statements)

References 67 publications

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“…By comparison, NEFA oxidation in these experiments was about 3-fold higher than CM-TAG oxidation by control hearts (and hence comparable to CM-TAG oxidation by diabetic hearts) [27] suggesting a general dysregulation of fatty acid beta-oxidation in the absence of glucose uptake. STZ-diabetic rat hearts utilised rat CM-TAG to a greater extent (about 50% more) than control rat hearts, consistent with increased cardiac LPL activity [22], whilst STZ-diabetic rat CMs were utilised even more avidly by both diabetic and non-diabetic rat hearts (about doubled), suggesting functional/composition differences in STZ-CM [22]. Similar studies with type 2 diabetic Zucker (ZDF) rats found comparable results: diabetic hearts utilised diabetic CM to a greater extent than controls, due principally to increased TAG-FA oxidation rather than esterification of TAG-derived FA into cellular lipids [23], and was associated with increased LPL activity in diabetic hearts [23].…”

Section: Accepted Manuscriptmentioning

confidence: 57%

“…Of the VLDL-TAG-FA assimilated, about one quarter was incorporated into tissue lipids whilst the remainder was oxidised; by contrast, about 90% of CM-TAG was oxidised; the metabolic partitioning was not affected by NEFA [16]. Comparable results have also been reported [15,22,23]. However, other authors demonstrate competition between NEFA and VLDL-TAG.…”

Section: Cardiac Vldl-tag Utilisationmentioning

confidence: 58%

“…In diabetes, TGRLP, including CM, are structurally altered, and this may change their efficacy as substrates [20][21][22][23]. Myocardial lipid metabolism is also increased (and glucose utilisation suppressed) in diabetes (see [1,24]), so both substrate and cellular factors are likely to be important.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…VLDL from perfused rat livers (0.4mM) showed similar results: STZ-diabetic hearts utilised about 50% more (control) VLDL-TAG than non-diabetic hearts. Interestingly, diabetic VLDL-TAG (from perfused STZ-diabetic rat livers) was utilised only poorly by control hearts, but diabetic hearts utilised diabetic VLDL-TAG comparably to control VLDL-TAG (and CM-TAG) [22]. As with CM, myocardial factors (uptake and disposal mechanisms) and lipoprotein factors (LP particle composition) are both likely to be important in diabetes.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…14 translational (?heparanase-mediated) mechanisms, with increased H-LPL in diabetes [22,23] as a consequence of the hyperglycemia [53].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

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The role of triacylglycerol in cardiac energy provision

Evans

Hui‐Kang

2016

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Triacylglycerols (TAG) constitute the main energy storage resource in mammals, by virtue of their high energy density. This in turn is a function of their highly reduced state and hydrophobicity.Limited water solubility, however, imposes specific requirements for delivery and uptake mechanisms on TAG-utilising tissues, including the heart, as well as intracellular disposition. TAGs constitute potentially the major energy supply for working myocardium, both through bloodborne provision and as intracellular TAG within lipid droplets, but also provide the heart with fatty acids (FA) which the myocardium cannot itself synthesise but are required for glycerolipid derivatives with (non-energetic) functions, including membrane phospholipids and lipid signalling molecules. Furthermore they serve to buffer potentially toxic amphipathic fatty acid derivatives.Intracellular handling and disposition of TAGs and their FA and glycerolipid derivatives similarly requires dedicated mechanisms in view of their hydrophobic character. Dysregulation of utilisation can result in inadequate energy provision, accumulation of TAG and/or esterified species, and these may be responsible for significant cardiac dysfunction in a variety of disease states. This review will focus on the role of TAG in myocardial energy provision, by providing FAs from exogenous and endogenous TAG sources for mitochondrial oxidation and ATP production, and how this can change in disease and impact on cardiac function. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 3Key words:heart; triacylglycerol; very-low-density lipoprotein; VLDL; chylomicron; lipid droplet Highlights: Triacylglycerols are supplied to the myocardium within chylomicrons and VLDL  Heart assimilates triacylglycerol-rich lipoproteins by LPL and receptor-mediated routes  Exogenous triacylglycerol-derived fatty acids enter an intracellular lipid pool  Intracardiac triacylglycerol is an important source of fatty acids for oxidation  Dysregulation of triacylglycerol metabolism is associated with cardiac dysfunction

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Section: Accepted Manuscriptmentioning

confidence: 57%

Section: Cardiac Vldl-tag Utilisationmentioning

confidence: 58%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

“…14 translational (?heparanase-mediated) mechanisms, with increased H-LPL in diabetes [22,23] as a consequence of the hyperglycemia [53].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

See 3 more Smart Citations

The role of triacylglycerol in cardiac energy provision

Evans

Hui‐Kang

2016

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Lipids as New Targets

Domínguez

2012

Therapeutic Targets

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Lipoproteins: A Source of Cardiac Lipids

Drosatos

Goldberg

2014

Cardiac Energy Metabolism in Health and Disease

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Lipids are the major substrate for cardiac ATP production and they are derived from adipose tissue or lipoprotein triglycerides. Lipoproteins are synthesized in the liver and they obtain their mature form following interaction with enzymes that are present in the circulation. Lipoprotein-derived fatty acids are released by lipoprotein lipase and are then taken up by cardiomyocytes either passively or via fatty acid receptors, such as CD36. Uptake of remnant lipoproteins via cardiomyocyte lipoprotein receptors is also possible. Besides fatty acids, other hydrophobic molecules such as cholesteryl esters, retinyl esters and vitamins are delivered by lipoproteins to the heart. While lipids are important for normal cardiac function, excessive lipid uptake, also known as lipotoxicity, may lead to cardiac abnormalities. This chapter focuses on the role of lipoproteins in providing fatty acids and other essential lipids to the heart in healthy conditions as well as in cardiac disease.

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Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference

Cited by 11 publications

References 67 publications

The role of triacylglycerol in cardiac energy provision

The role of triacylglycerol in cardiac energy provision

Lipids as New Targets

Lipoproteins: A Source of Cardiac Lipids

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