Metabolite-mediated TOR signaling regulates the circadian clock in
            <i>Arabidopsis</i>

Zhang, Nan; Meng, Yanyan; Xu, Li; Zhou, Yu; Ma, Liuyin; Fu, Liwen; Schwarzländer, Markus; Liu, Hongtao; Xiong, Yan

doi:10.1073/pnas.1913095116

Cited by 49 publications

(50 citation statements)

References 16 publications

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“…Sugars fluctuate as a consequence of carbon homeostasis and photosynthesis (Webb et al, 2019), whereas nicotinamide is a breakdown product of NAD acting as a substrate for post‐translational modifications including poly(ADP‐ribosyl)ation and protein deacetylation, and for the production of the Ca 2+ agonist cyclic ADP‐ribose (cADPR; Hunt, Lerner, & Ziegler, 2004). Nicotinamide lengthens circadian period in all organisms tested with proposed modes of action being through inhibition of poly(ADP‐ribose) polymerases (PARPs), sirtuins (SRTs), ADPR cyclases, the reduction of H3K4me3 accumulation, target of Rapamycin (TOR) and the action of BIG, a protein of unknown function (Asher et al, 2008; Asher et al, 2010; Dodd et al, 2007; Hearn et al, 2018; Malapeira, Crhak Khaitova, & Mas, 2012; Mombaerts et al, 2019; Nakahata et al, 2008; Zhang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Arabidopsis sirtuins and poly(ADP‐ribose) polymerases regulate gene expression in the day but do not affect circadian rhythms

Kim

Bell

Wang

et al. 2021

Plant Cell & Environment

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Nicotinamide-adenine dinucleotide (NAD) is involved in redox homeostasis and acts as a substrate for NADases, including poly(ADP-ribose) polymerases (PARPs) that add poly(ADP-ribose) polymers to proteins and DNA, and sirtuins that deacetylate proteins.Nicotinamide, a by-product of NADases increases circadian period in both plants and animals. In mammals, the effect of nicotinamide on circadian period might be mediated by the PARPs and sirtuins because they directly bind to core circadian oscillator genes.We have investigated whether PARPs and sirtuins contribute to the regulation of the circadian oscillator in Arabidopsis. We found no evidence that PARPs and sirtuins regulate the circadian oscillator of Arabidopsis or are involved in the response to nicotinamide. RNA-seq analysis indicated that PARPs regulate the expression of only a few genes, including FLOWERING LOCUS C. However, we found profound effects of reduced sirtuin 1 expression on gene expression during the day but not at night, and an embryo lethal phenotype in knockouts. Our results demonstrate that PARPs and sirtuins are not associated with NAD regulation of the circadian oscillator and that sirtuin 1 is associated with daytime regulation of gene expression.

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Section: Introductionmentioning

confidence: 99%

Arabidopsis sirtuins and poly(ADP‐ribose) polymerases regulate gene expression in the day but do not affect circadian rhythms

Kim

Bell

Wang

et al. 2021

Plant Cell & Environment

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“…Meanwhile, another report also suggested that TOR signaling mediates metabolite-regulated circadian clock in Arabidopsis. 18 Taken together, these findings unequivocally uncovered that TOR can feedback-regulate circadian clock in Arabidopsis.…”

Section: Resultsmentioning

confidence: 75%

Attenuated TOR signaling lengthens circadian period in Arabidopsis

Wang

Qin

et al. 2020

Plant Signaling & Behavior

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By timing many diel rhythmic events, circadian clock provides an adaptive advantage for higher plants. Meanwhile, circadian clock displays plasticity and can be entrained by the external environmental cues and internal factors. However, whether cellular energy status can regulate circadian clock is largely unknown in higher plants. The evolutionarily conserved TOR (target of rapamycin) signaling among eukaryotic organisms has been implicated as an integrator for cellular nutrient and energy status. Here, we demonstrated that chemically blocking electron transport chain of mitochondrial can lengthen the circadian period. Similarly, chemical inhibition of TOR activity by Torin 1, a specific inhibitor for TOR kinase, and knockdown of TOR transcript levels significantly elongate the circadian period as well. Our findings imply that TOR signaling may mediate energy status-regulated circadian clock in plants, and the reciprocal regulation between the circadian clock and TOR signaling might be an evolutionary mechanism for fitness and adaptation in plants.

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“…This glucose activation of the TOR pathway is prevented by 2-deoxy-glucose and by inhibitors of the electron transport chain, indicating that glucose needs to pass through glycolysis and the electron transport chain to give TOR activation, as reported in Figure 3 [123]. In addition, it was recently reported that nicotinamide (vitamin B3) affects ATP level and inhibits the glucose-TOR signaling, regulating the circadian clock, meristem activation and root growth [124]. Although the precise molecular mechanism of glucose activation is still unknown, this last study suggests a link between the energetic status of the cell and TOR activity.…”

Section: Protein-metabolite Interactions Controlling Tor Activity In mentioning

confidence: 76%

The Regulatory Role of Key Metabolites in the Control of Cell Signaling

2020

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Robust biological systems are able to adapt to internal and environmental perturbations. This is ensured by a thick crosstalk between metabolism and signal transduction pathways, through which cell cycle progression, cell metabolism and growth are coordinated. Although several reports describe the control of cell signaling on metabolism (mainly through transcriptional regulation and post-translational modifications), much fewer information is available on the role of metabolism in the regulation of signal transduction. Protein-metabolite interactions (PMIs) result in the modification of the protein activity due to a conformational change associated with the binding of a small molecule. An increasing amount of evidences highlight the role of metabolites of the central metabolism in the control of the activity of key signaling proteins in different eukaryotic systems. Here we review the known PMIs between primary metabolites and proteins, through which metabolism affects signal transduction pathways controlled by the conserved kinases Snf1/AMPK, Ras/PKA and TORC1. Interestingly, PMIs influence also the mitochondrial retrograde response (RTG) and calcium signaling, clearly demonstrating that the range of this phenomenon is not limited to signaling pathways related to metabolism.

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Metabolite-mediated TOR signaling regulates the circadian clock in Arabidopsis

Cited by 49 publications

References 16 publications

Arabidopsis sirtuins and poly(ADP‐ribose) polymerases regulate gene expression in the day but do not affect circadian rhythms

Arabidopsis sirtuins and poly(ADP‐ribose) polymerases regulate gene expression in the day but do not affect circadian rhythms

Attenuated TOR signaling lengthens circadian period in Arabidopsis

The Regulatory Role of Key Metabolites in the Control of Cell Signaling

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