Metabolite profiling and wound-healing activity of Boerhavia diffusa leaf extracts using in vitro and in vivo models

Juneja, Kriti; Mishra, Rutusmita; Chauhan, Samrat; Gupta, Sumeet; Roy, Partha; Sircar, Debabrata

doi:10.1016/j.jtcme.2019.02.002

Cited by 52 publications

(27 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Juneja et al. 38 reported that the flavonoids from Boerhavia diffusa leaf extracts improved wound healing by enhancement in fibroblast growth and collagen fibrils, similar to our result.…”

Section: Discussionsupporting

confidence: 91%

Gel formulations of Merremia mammosa (Lour.) accelerated wound healing of the wound in diabetic rats

Marchianti

Sakinah

Elfiah

et al. 2021

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

Background and aim The treatment of diabetic ulcers is difficult because of defective blood vessels and frequent co-occurrence of bacterial infections. In a previous study, we found a water fraction of Merremia mammosa (Lour.) (Mm(Lour.)) had beneficial effects on wound healing in diabetic rats. This study aimed to evaluate the influence of different gelling agents added to Mm(Lour.) water fraction gel on wound healing treatment in diabetic rats. Experimental procedure Diabetic Wistar rats were divided into the following five groups: 1. positive control (Neomycin Sulfate 0.5% and Placenta Extract 10%), 2. negative control (distilled water), and 10% water fraction of Mm(Lour.) extract in 3. HPMC, 4. Carbopol, and 5. CMC Na gelling agents. The wound was made by the Morton method and treatment applied every other day for 25 days, then the wound healing process was observed. Data were observed and analysed using appropriate statistic tools. Results Histopathology observation, VEGF expression and hydroxyproline levels showed a significant acceleration of wound healing in all treatment groups compared to the negative control group. This study showed all of Mm(Lour.) gel formulations could restore the delayed healing process on wound in diabetic rats and were equally effective in accelerating wound healing. CMC Na was the most preferable because it did not irritate. Conclusion The results suggest that Mm(Lour.) water fraction in CMC Na gelling agent provided an option to be developed as a topical drug on diabetic wound healing treatment, showed by enhancement of collagen synthesis and angiogenesis.

show abstract

“…Juneja et al. 38 reported that the flavonoids from Boerhavia diffusa leaf extracts improved wound healing by enhancement in fibroblast growth and collagen fibrils, similar to our result.…”

Section: Discussionsupporting

confidence: 91%

Gel formulations of Merremia mammosa (Lour.) accelerated wound healing of the wound in diabetic rats

Marchianti

Sakinah

Elfiah

et al. 2021

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

show abstract

“…Several of these plant metabolites such as rotenoids (Boeravinone A-G), kaempferol, and quercetin have been proven for their role in hepatoprotective activity (Lami et al, 1990;Borrelli et al, 2005;Ferreres et al, 2005;Pereira et al, 2009;Bairwa et al, 2013). B. diffusa L. plant extract has been found to modulate CCl 4 induced liver injury in stimulated animals through the reduction of cytochrome (CYP) enzyme activities (Ramachandra et al, 2011;Venkatesh et al, 2012;Bairwa et al, 2013;Patel and Verma, 2014;Ekow Thomford et al, 2018;Juneja et al, 2020). P. niruri L. also known as 'bhumi amalaki' is composed of alkaloids, anthrocyanins, chlorogenic acids, flavonoids, lignans, phenolic acids, tannins, terpenoids, saponins, and substitutes that attribute to its bioactivity (Kaur et al, 2017;Jantan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Polyherbal Medicine Divya Sarva-Kalp-Kwath Ameliorates Persistent Carbon Tetrachloride Induced Biochemical and Pathological Liver Impairments in Wistar Rats and in HepG2 Cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Caffeic acid (known as 3,4-dihydroxycinnamic acid) is a secondary plant metabolite and one of the most abundant bioactive dihydroxycinnamic acids [ 67 ], and it consists of dihydroxyl and α,β-unsaturated (acrylic) carboxylic groups. This phenolic compound can be found in many food sources, as illustrated in Figure 1 , such as coffee drinks, propolis, blueberries, apples, cider, potatoes, spinach, lettuce, cabbage, olive oil, wine, and tobacco leaves [ 68 , 69 ], and in some traditional medicinal herbs [ 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ].…”

Section: Hydroxycinnamic Acids and Derivatives: General Uses And Current Applicationsmentioning

confidence: 99%

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

et al. 2021

View full text Add to dashboard Cite

Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are locally characterized by an intense inflammatory response, a high generation of harmful free radicals, or an impairment in the immune response regulation, which can profoundly change the skin tissue’ repair process, vulnerability, and functionality. Moreover, diabetes diffusion, antibiotic resistance, and abuse of aggressive soaps and disinfectants following the COVID-19 emergency could be causes for the future spreading of skin disorders. In the last years, hydroxycinnamic acids and derivatives have been investigated and applied in several research fields for their anti-oxidant, anti-inflammatory, and anti-bacterial activities. First, in this study, we give an overview of these natural molecules’ current source and applications. Afterwards, we review their potential role as valid alternatives to the current therapies, supporting the management and rebalancing of skin disorders and diseases at different levels. Also, we will introduce the recent advances in the design of biomaterials loaded with these phenolic compounds, specifically suitable for skin disorders treatments. Lastly, we will suggest future perspectives for introducing hydroxycinnamic acids and derivatives in treating skin disorders.

show abstract

Metabolite profiling and wound-healing activity of Boerhavia diffusa leaf extracts using in vitro and in vivo models

Cited by 52 publications

References 30 publications

Gel formulations of Merremia mammosa (Lour.) accelerated wound healing of the wound in diabetic rats

Gel formulations of Merremia mammosa (Lour.) accelerated wound healing of the wound in diabetic rats

Polyherbal Medicine Divya Sarva-Kalp-Kwath Ameliorates Persistent Carbon Tetrachloride Induced Biochemical and Pathological Liver Impairments in Wistar Rats and in HepG2 Cells

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Contact Info

Product

Resources

About