Metabolites from Aspergillus versicolor, an endolichenic fungus from the lichen Lobaria retigera

Dou, Yanli; Wang, Xiaoling; Jiang, Dai-Feng; Wang, Haiying; Jiao, Yang; Lou, Hongxiang; Wang, Xiaoning

doi:10.5582/ddt.8.84

Cited by 37 publications

(17 citation statements)

References 17 publications

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“…In many cases the host lichens are unknown either, which hampers reproducibility of the results. Exceptions are Aspergillus versicolor , producing three new anthraquinones derivatives, isolated form the lung lichen Lobaria retigera [ 42 ], and Sporomiella irregularis producing the new xanthone glycoside sporormielloside, isolated from Usnea mutabilis [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Growth Media on the Diversity of Culturable Fungi from Lichens

2017

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Microscopic and molecular studies suggest that lichen symbioses contain a plethora of associated fungi. These are potential producers of novel bioactive compounds, but strains isolated on standard media usually represent only a minor subset of these fungi. By using various in vitro growth conditions we are able to modulate and extend the fraction of culturable lichen-associated fungi. We observed that the presence of iron, glucose, magnesium and potassium in growth media is essential for the successful isolation of members from different taxonomic groups. According to sequence data, most isolates besides the lichen mycobionts belong to the classes Dothideomycetes and Eurotiomycetes. With our approach we can further explore the hidden fungal diversity in lichens to assist in the search of novel compounds.

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Section: Discussionmentioning

confidence: 99%

Effects of Growth Media on the Diversity of Culturable Fungi from Lichens

2017

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“…Some fungal mycobiontes involved in lichen associations also proved their capacity to produce several original anthraquinoid molecules in separate cultures. For instance, Aspergillus versicolor , a mycobionte in Lobaria retigera excretes averythin, 8- O -methylaverythin, 8- O -methylversicolorin A and B, 6,8-di- O -methylversicolorin A, 6,8-di- O -methylaverufin, and 6,8,1′-tri- O -methylaverantin [ 108 ].…”

Section: Anthraquinones From Marine-derived Fungimentioning

confidence: 99%

Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities

et al. 2016

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Anthraquinones and their derivatives constitute a large group of quinoid compounds with about 700 molecules described. They are widespread in fungi and their chemical diversity and biological activities recently attracted attention of industries in such fields as pharmaceuticals, clothes dyeing, and food colorants. Their positive and/or negative effect(s) due to the 9,10-anthracenedione structure and its substituents are still not clearly understood and their potential roles or effects on human health are today strongly discussed among scientists. As marine microorganisms recently appeared as producers of an astonishing variety of structurally unique secondary metabolites, they may represent a promising resource for identifying new candidates for therapeutic drugs or daily additives. Within this review, we investigate the present knowledge about the anthraquinones and derivatives listed to date from marine-derived filamentous fungi′s productions. This overview highlights the molecules which have been identified in microorganisms for the first time. The structures and colors of the anthraquinoid compounds come along with the known roles of some molecules in the life of the organisms. Some specific biological activities are also described. This may help to open doors towards innovative natural substances.

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“…Research already conducted in the field indicates that fungal endophytes are diverse, largely undiscovered, and potentially key sources of novel bioactive compounds. In contrast to the large number of research studies conducted on the bioactive endophytes isolated from plants, few studies have been conducted on culturable asymptomatic fungi existing within lichen thalli, which are also potential sources of bioactive metabolites . Endolichenic fungal metabolites possess a diverse array of bioactivities, such as anticancer, antiviral, antibacterial, antifungal, and anti‐Alzheimer's disease effects .…”

Section: Introductionmentioning

confidence: 99%