Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1

Abstract

Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-β-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh2(OCOCF3)4-induced ECD experiments, and Marfey’s method. Compound 1 showed cytotoxicity against the K562 cell line with IC50 values of 13.10 ± 0.08 μM. Moreover, compounds 1 and 5 exhibited inhibitory activity against α-glycosidase with IC50 values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively.

Marine natural products

“…isolated from Cerops tagal roots produced two simple benzoic acid derivatives cladoslides A and B 827 and B 828, a b-carboline cladospomine 829 and a pyridin-2(1H)-one cladoslide C 830. 319 The rst naturally occurring ergosterol purine hybrid 831 was isolated from Penicillium brefeldianum. 320 Six new 4-quinolone alkaloids oxypenicinolines A-D 832-839, penicinoline F 840 and penicinoline G 841 were isolated from Penicillium steckii.…”

“…isolated from Cerops tagal roots produced two simple benzoic acid derivatives cladoslides A and B 827 and B 828 , a β-carboline cladospomine 829 and a pyridin-2(1 H )-one cladoslide C 830 . 319 The first naturally occurring ergosterol purine hybrid 831 was isolated from Penicillium brefeldianum . 320 …”

Anti-Tumor Secondary Metabolites Originating from Fungi in the South China Sea’s Mangrove Ecosystem

“…A new benzoic acid, cladoslide A ( 40 ) from Cladosporium sp. HNWSW-1, was discovered to be cytotoxic to the K562 cells with an IC 50 value of 13.10 ± 0.08 μM [ 35 ]. Terphenyllin ( 41 ) was obtained from A. candidus (HS-Y-23), which showed weak cytotoxicity against HeLa cells with an IC 50 value of 19.0 µM [ 23 ].…”

Field Control Effect and Initial Mechanism: A Study of Isobavachalcone against Blister Blight Disease

“…Phyllosphere microbial communities are closely related to plant health as well as disease progression [ 29 ]. High-throughput sequencing techniques are extensively applied for the comprehensive analysis of the structure of the microbial communities of the phyllosphere microbiome [ 30 , 31 , 32 ]. An internal transcribed spacer (ITS) is currently used for amplification to analyze phyllosphere fungal communities.…”