Metabolites of Chlorinated Syringaldehydes in Fish Bile as Biomarkers of Exposure to Bleached Eucalypt Pulp Effluents

Brumley, C.M.; Haritos, Victoria S.; Ahokas, Jorma T.; Holdway, Douglas A.

doi:10.1006/eesa.1996.0032

Cited by 9 publications

(3 citation statements)

References 2 publications

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“…He continued his successful career in Australia and became Australia's first Professor of Toxicology at RMIT University in Melbourne in 1990. Over the years, he continued to develop biomonitoring methods, for example using liver enzyme activities of local fish in situ . Recently, one of his PhD students, Danielle Sevior, did part of her thesis in Oulu, studying potential herb–drug interactions and writing a mini review .…”

Section: Evolutionary Xenobiotic Metabolismmentioning

confidence: 99%

Drug Metabolism – From In Vitro to In Vivo, From Simple to Complex

Pelkonen

2015

Basic Clin Pharma Tox

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Drug metabolism is the crucial part of pharmaco-and toxicokinetics and consequently is associated with both desirable and adverse effects of most xenobiotics, compounds foreign to the body. This minireview follows some advances of the field over the last 50 years or so through the experiences and work of one scientist. Thus, this minireview represents a rather personal view of research in one research field. Drug metabolism is affected and controlled by a huge number of factors and conditions such as individual development, species differences, drug-drug interactions and various environmental, host and genetic factors working via a variable set of regulatory mechanisms. All these different factors create wide individual, population and species variability with obvious repercussions to clinical drug therapy and chemical risk assessment. This minireview also provides glimpses to methodological developments over recent decades and ends up presenting a few promising approaches and techniques such as various omics and high-content and high-throughput techniques feeding huge amounts of data to computational integration and modelling, which constitute the basis for systems or network pharmacology and toxicology.

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Section: Evolutionary Xenobiotic Metabolismmentioning

confidence: 99%

Drug Metabolism – From In Vitro to In Vivo, From Simple to Complex

Pelkonen

2015

Basic Clin Pharma Tox

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“…Exposure. Metabolites of chlorinated phenoloic compounds in fish bile have been found to be sensitive biomarkers of bleach pulp mill effluent exposure (Brumley et al 1996). Analysis of metabolites of chlorinated syringaldehydyes in fish bile can provide a biomarker of effluent exposure that is sensitive to low levels of exposure and correlates well with exposure concentrations.…”

Section: Identification Of Data Needsmentioning

confidence: 99%

Toxicological profile for chlorine dioxide and chlorite

Taylor¹,

Wohlers²,

Amata³

2004

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"Toxicological Profile for Chlorine Dioxide and Chlorite, Draft for Public Comment was released in September 2002. This edition supersedes any previously released draft or final profile. Chemical manager(s)/author(s): Jessilynn B. Taylor, ATSDR, Division of Toxicology, Atlanta, GA; David Wohlers, Richard Amata, Syracuse Research Corporation, North Syracuse, NY. CAS#: 10049-04-4 (Chlorine Dioxide); 7758-19-2 (Chlorite)"

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“…The main biliary metabolite found in sand flathead exposed for 4 days to chlorine dioxide bleached eucalypt pulp effluent or injected 2-CSA has been identified as the glucuronide or sulfate conjugate of 2-chloro-4-hydroxy-3,5-dimethoxybenzylalcohol (2-CB-OH) Brumley et al, 1996b). This metabolite has been detected in the bile of fish exposed to highly diluted bleached eucalypt pulp effluent, and its biliary concentration has been correlated in a predictable manner with effluent concentration.…”

Section: Introductionmentioning

confidence: 99%